122 patents
Page 3 of 7
Utility
Forms of 5-({[2-AMINO-3-(4-CARBAMOYL-2,6-DIMETHYL-PHENYL)-PROPIONYL]-[1-(4-PHENYL-1H-IMIDAZOL-2-YL)-ETHYL]-AMINO}-METHYL)-2-METHOXY-BENZOIC Acid
20 Apr 23
The present invention relates to novel crystalline Forms C, C′, D′ and H3 of 5-({[2-amino (4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of preparing the same.
Thomas Karami, Qi Gao
Filed: 30 Mar 21
Utility
In Vivo Synthesis of Elastic Fiber
20 Apr 23
Disclosed herein are methods of restoring elasticity in tissue using tropoelastin containing compositions.
Suzanne Marie MITHIEUX, Anthony Steven WEISS
Filed: 6 Jul 22
Utility
Process and System for Obtaining Botulinum Neurotoxin
20 Apr 23
Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.
Jennifer L. Ton, Hermant A. Patel, Ronald C. Bates, Wajdie M. Ahmad
Filed: 19 Dec 22
Utility
COMPLEMENT FACTOR Bb ANTIBODIES
20 Apr 23
The present disclosure relates to antibodies and polynucleotides encoding the same, which may be used to prevent, control, or reduce the activity of the complement pathway.
Yanbin LIANG, Chen LI, Iris LEE, Victor M. GUZMAN
Filed: 12 Aug 22
Utility
Tissue Engineering Scaffolds
6 Apr 23
The present disclosure relates to a hybrid material, such as a hybrid yarn, as well as methods of making and using the same.
Anthony Steven WEISS, Behnaz AGHAEI-GHAREH-BOLAGH
Filed: 8 Feb 21
Utility
Combination Therapy with CGRP Antagonists and Clostridial Derivatives
6 Apr 23
Methods for treating headache, migraine and related symptoms by administering a CGRP antagonist and a Clostridial derivative are described.
Andrew M. Blumenfeld, Mitchel F. Brid
Filed: 2 May 22
Utility
Methods for Treatment of Masseter Muscle Hypertrophy
16 Mar 23
Methods and kits for treating or alleviating masseter muscle hypertrophy by local administration of a Clostridial derivative, such as a botulinum toxin, to the masseter muscle are described.
Elisabeth Lee, Beta Bowen, Christine Somogyi, John D. Rogers
Filed: 30 May 22
Utility
Methods for Treatment of Masseter Muscle Hypertrophy
16 Mar 23
Methods and kits for treating or alleviating masseter muscle hypertrophy by local administration of a Clostridial derivative, such as a botulinum toxin, to the masseter muscle are described.
Elisabeth Lee, Beta Bowen, Christine Somogyi, John D. Rogers
Filed: 30 May 22
Utility
Lighter Weight Implant
9 Mar 23
A breast implant is provided which includes a filling, or core having a lower overall density relative to silicone gel-filled or saline-filled implant.
David Schuessler
Filed: 14 Nov 22
Utility
Methods of Treating Alpha Adrenergic Mediated Conditions
2 Mar 23
Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator.
Daniel W. Gil, John E. Donello, Wenkui K. Fang, Phong X. Nguyen, Ken Chow, Todd M. Heidelbaugh, Dario G. Gomez, Michael E. Garst, Santosh C. Sinha
Filed: 9 Nov 21
Utility
Skin Treatment System with Adjustable Height Wand
23 Feb 23
A distance between a surface of a treatment head and tip opening of a skin treatment hand piece is adjustable.
N. Brendon Boone, III, Basil M. Hantash, Kenneth B. Karasiuk, Steven E. Wojcik
Filed: 20 Oct 22
Utility
Stable Formulations of Linaclotide
28 Jul 22
The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
Yun Mo, Angelika Fretzen, Brian Cali, Mahendra Dedhiya
Filed: 14 Apr 22
Utility
Stable Solid Formulation of GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
28 Apr 22
Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations.
Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
Filed: 7 Jan 22
Utility
Treatment of Constipation-Predominant Irritable Bowel Syndrome
14 Apr 22
The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.
Jeffrey Johnston, Bernard Joseph Lavins, Harvey Schneier
Filed: 20 Dec 21
Utility
Low-Dose Stable Formulations of Linaclotide
3 Feb 22
The present invention relates to stable pharmaceutical compositions comprising linaclotide or pharmaceutically acceptable salts thereof, as well as to various methods and processes for the preparation and use of the compositions.
Yun Mo, Caroline Kurtz
Filed: 18 Oct 21
Utility
Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
23 Sep 21
Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations.
Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
Filed: 2 Jun 21
Utility
Formation of Bone
11 Feb 21
Compositions and methods for inducing or promoting repair of a bone fracture.
Fariba DEHGHANI, Ali FATHI, Suzanne Marie MITHIEUX, Anthony Steven WEISS
Filed: 17 Jul 20
Utility
Method for Stabilizing a Toxin
11 Feb 21
Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.
Terrence J. Hunt
Filed: 15 Oct 20
Utility
Animal Product Free System and Process for Purifying a Botulinum Toxin
28 Jan 21
Chromatographic processes and systems for purifying a botulinum toxin from an APF fermentation medium.
Hui Xiang
Filed: 6 Oct 20
Utility
Dual Cap System for Container-closures to Maintain Tip Sterility During Shelf Storage
21 Jan 21
A container-closure system includes a container configured to hold a therapeutic liquid and having a dispensing tip configured to dispense a dose of the therapeutic liquid.
Sai Shankar
Filed: 5 Oct 20