154 patents
Page 6 of 8
Utility
Methods for Simultaneous Amplification of Target Loci
28 Jan 21
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
Filed: 2 Oct 20
Utility
Compositions, methods, and kits for isolating nucleic acids
19 Jan 21
Disclosed here is a composition for isolating nucleic acids from a biological sample, comprising a chaotropic compound and a solvent, wherein the solvent comprises a nitrile compound, tetrahydrofuran, or a combination thereof.
James Stray, Jason Tong, Xiaoke Wang
Filed: 15 Feb 18
Utility
Methods for Isolating Nucleic Acids with Size Selection
14 Jan 21
Disclosed here is a method for isolating nucleic acids from a biological sample, comprising: (a) contacting a first composition comprising nucleic acids obtained from a biological sample with a first matrix under a low-stringency binding condition having less than 1% aliphatic alcohols that binds less than 5% of nucleic acids of shorter than about 118 bp and more than 30% of nucleic acids longer than about 194 bp to a first matrix; and (b) contacting a second composition comprising remainder of the first composition with a second matrix under a high-stringency binding condition having less than 1% aliphatic alcohol that binds more than 70% of nucleic acids longer than about 72 bp and 30% of nucleic acids longer than about 50 bp to the second matrix.
James STRAY, Jason TONG
Filed: 15 Feb 19
Utility
Methods for Non-invasive Prenatal Paternity Testing
30 Dec 20
Methods for non-invasive prenatal paternity testing are disclosed herein.
Allison RYAN, Styrmir SIGURJONSSON, Milena BANJEVIC, George GEMELOS, Matthew HILL, Johan BANER, Matthew RABINOWITZ, Zachary DEMKO
Filed: 10 Sep 20
Utility
Methods for Simultaneous Amplification of Target Loci
30 Dec 20
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
Filed: 10 Sep 20
Utility
System and Method for Cleaning Noisy Genetic Data from Target Individuals Using Genetic Data from Genetically Related Individuals
18 Nov 20
A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed.
Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
Filed: 30 Jun 20
Utility
Methods for Simultaneous Amplification of Target Loci
4 Nov 20
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
Filed: 20 Jul 20
Utility
Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
4 Nov 20
Provided herein are methods for determining the ploidy state of one or more chromosome in a developing fetus.
Matthew RABINOWITZ
Filed: 20 Jul 20
Utility
Methods for Simultaneous Amplification of Target Loci
7 Oct 20
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
Filed: 22 Apr 20
Utility
Methods for simultaneous amplification of target loci
5 Oct 20
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Joshua Babiarz, Tudor Popiliu Constantin, Lane A. Eubank, George Gemelos, Matthew Micah Hill, Huseyin Eser Kirkizlar, Matthew Rabinowitz, Onur Sakarya, Styrmir Sigurjonsson, Bernhard Zimmermann
Filed: 29 Apr 19
Utility
Methods for multiplex PCR amplification of target loci in a nucleic acid sample
14 Sep 20
Methods for non-invasive prenatal paternity testing are disclosed herein.
Allison Ryan, Styrmir Sigurjonsson, Milena Banjevic, George Gemelos, Matthew Hill, Johan Baner, Matthew Rabinowitz, Zachary Demko
Filed: 26 Feb 19
Utility
System and Method for Cleaning Noisy Genetic Data and Determining Chromosome Copy Number
5 Aug 20
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available.
Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
Filed: 7 Apr 20
Utility
Method of Detecting Tumour Recurrence
5 Aug 20
The invention relates to subject-specific methods for detecting recurrence of tumours based on an understanding of the clonal/subclonal mutation profile of the subject's tumour and detection of the mutations in their cell-free DNA (cfDNA), typically by multiplex PCR of tumour mutations such as single nucleotide variants (SNVs).
Robert Charles SWANTON, Christopher ABBOSH
Filed: 31 Oct 17
Utility
Methods for simultaneous amplification of target loci
3 Aug 20
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Joshua Babiarz, Tudor Pompiliu Constantin, Lane A. Eubank, George Gemelos, Matthew Micah Hill, Huseyin Eser Kirkizlar, Matthew Rabinowitz, Onur Sakarya, Styrmir Sigurjonsson, Bernhard Zimmermann
Filed: 14 Jan 20
Utility
System and Method for Cleaning Noisy Genetic Data and Determining Chromosome Copy Number
22 Jul 20
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available.
Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
Filed: 17 Mar 20
Utility
Methods for Simultaneous Amplification of Target Loci
22 Jul 20
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
Filed: 24 Mar 20
Utility
System and Method for Cleaning Noisy Genetic Data and Determining Chromosome Copy Number
15 Jul 20
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available.
Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
Filed: 12 Mar 20
Utility
System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
13 Jul 20
A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed.
Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
Filed: 29 Apr 19
Utility
Methods for Simultaneous Amplification of Target Loci
1 Jul 20
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Bernhard ZIMMERMANN, Matthew HILL, Philippe LACROUTE, Michael DODD, Alexander WONG
Filed: 23 Jan 20
Utility
Methods for Simultaneous Amplification of Target Loci
1 Jul 20
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods.
Joshua BABIARZ, Tudor Pompiliu CONSTANTIN, Lane A. EUBANK, George GEMELOS, Matthew Micah HILL, Huseyin Eser KIRKIZLAR, Matthew RABINOWITZ, Onur SAKARYA, Styrmir SIGURJONSSON, Bernhard ZIMMERMANN
Filed: 11 Mar 20