20 patents
Utility
Methods and Devices for Spatially Resolved Analysis of Proteomic and Genetic Information
11 Jan 24
Disclosed are devices and methods capable of determining spatially resolved information from a biological sample including genomic, transcriptomic, and proteomic information.
Rui ZHENG, Sean MACKAY
Filed: 18 Aug 23
Utility
Methods and Devices for Mulitplexed Proteomic and Genetic Analysis and On-device Preparation of Cdna
28 Dec 23
Disclosed are devices and methods capable of multiplexed analysis of multiple cellular activities and pathways in single cells including genomic, transcriptomic, and proteomic analysis.
Rui ZHENG, Dana ASHWORTH, Sean MACKAY
Filed: 3 Nov 21
Utility
Methods and Compositions for Incorporating Nucleotides
21 Dec 23
The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods.
Steven GORDON, Jerzy OLEJNIK
Filed: 30 May 23
Utility
Dna Sequencing Reaction Additive
26 Oct 23
The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3′-O position capped by a disulfide-based 3′-terminator group are used.
Luisa ANDRUZZI, Jimmy ADEDIRAN, Timothy PELLETIER, Austin RICKER, Angela DELUCIA, Ben MCNALLY, Dona HEVRONI, Mong Sano MARMA, John Andrew SHERIDAN
Filed: 6 Apr 23
Utility
System and Methods for Multiplexed Analysis of Cellular and Other Immunotherapeutics
13 Jul 23
Disclosed are methods of identifying a secretome from a subject cell within a heterogeneous cell population when the subject cell contacts a target cell (e.g. a subject immune cell contacts a target cancer cell) or a stimulatory agent and methods of using the identified secretome to identify cells that are safe and efficacious for cellular therapies, including adoptive CAR T-cell therapies.
Sean MACKAY, Colin NG, Emily BETTINI
Filed: 9 Mar 23
Utility
Analysis and Screening of Cell Secretion Profiles
4 May 23
Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components.
Patrick PACZKOWSKI, Sean MACKAY, Sean MCCUSKER
Filed: 23 Dec 22
Utility
Systems, Devices and Methods for Cell Capture and Methods of Manufacture Thereof
16 Feb 23
Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles.
Peter TSIOMPLIKAS, Jerry SEDGEWICK, Jeffrey WHYNALL, Sean MACKAY, Colin NG, Patrick PACZKOWSKI, Sean MCCUSKER, Igor NIKONOROV, Alaina KAISER
Filed: 26 Oct 22
Utility
Compositions and Methods for the Simultaneous Genomic, Transcriptomic and Proteomic Analysis of Single Cells
8 Dec 22
Colin NG, Alaina KAISER, Emily BETTINI, Patrick PACZKOWSKI, Sean MACKAY, Feimei LIU, Maithreyan SRINIVASAN
Filed: 10 Jun 22
Utility
Thiol-containing Cleave Reagents and Oxidative Wash
6 Oct 22
The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside.
Mong Sano MARMA, Luisa ANDRUZZI, Ben MCNALLY, Angela DELUCIA, Dona HEVRONI, Elizabeth CARPENTER, Magnus BESEV
Filed: 3 Feb 22
Utility
Methods and Devices for Amplification of Nucleic Acid
4 Aug 22
The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions.
Steven GORDON, Daniel STETSON
Filed: 10 Sep 21
Utility
Nucleotide Analogues
26 May 22
The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside.
Mong Sano MARMA, Jerzy Olejnik, Ilia Korboukh
Filed: 28 Jun 21
Utility
Polymerase Enzyme from Pyrococcus Abyssi
12 May 22
Jerzy Olejnik, Angela Delucia, Cheng-yao Chen, Ryan Charles Heller, Thomas William Schoenfeld
Filed: 13 Feb 18
Utility
Analysis and Screening of Cell Secretion Profiles
5 May 22
Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components.
Patrick PACZKOWSKI, Sean MACKAY, Sean MCCUSKER
Filed: 10 Jun 21
Utility
Polymerase Enzyme from Pyrococcus Furiosus
28 Apr 22
The present invention relates to a polymerase enzyme from Pyrococcus furiosus with improved ability to incorporate reversibly terminating nucleotides.
Jerzy Olejnik, Angela Delucia, Cheng-yao Chen, Ryan Charles Heller, Thomas William Schoenfeld
Filed: 13 Feb 18
Utility
Systems, Devices and Methods for Identification, Selective Ablation, and Selection and Collection of Single Cells
20 Jan 22
Embodiments of the present disclosure are directed to systems, devices, and methods for the selective collection of cells from a heterogeneous cell population, including highly multiplexed detection of secreted and intracellular macromolecules and the targeted laser-assisted ablation of cells identified to be positive or negative for a given biomarker or phenotype.
Rui ZHENG, Sean MACKAY
Filed: 4 Dec 19
Utility
Photoprotective Mixtures As Imaging Reagents In Sequencing-by-synthesis
30 Dec 21
The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods.
Luisa ANDRUZZI, Michel Georges PERBOST, Dona HEVRONI, Minakshi GUHA, Austin RICKER, Timothy PELLETIER
Filed: 10 Sep 21
Utility
Polyphenolic Additives In Sequencing-by-synthesis
18 Nov 21
The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods.
Jerzy OLEJNIK, Michel Georges PERBOST
Filed: 28 Jul 21
Utility
Analysis and Screening of Cell Secretion Profiles
29 Jul 20
Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components.
Patrick PACZKOWSKI, Sean MACKAY, Sean MCCUSKER
Filed: 26 Jan 20
Utility
System and Methods for Multiplexed Analysis of Cellular and Other Immunotherapeutics
27 May 20
Disclosed are methods of identifying a secretome from a subject cell within a heterogeneous cell population when the subject cell contacts a target cell (e.g. a subject immune cell contacts a target cancer cell) or a stimulatory agent and methods of using the identified secretome to identify cells that are safe and efficacious for cellular therapies, including adoptive
Sean MACKAY, Colin NG, Emily BETTINI
Filed: 11 Sep 17
Utility
Systems, Devices and Methods for Cell Capture and Methods of Manufacture Thereof
11 Dec 19
Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles.
Peter TSIOMPLIKAS, Jerry SEDGEWICK, Jeffrey WHYNALL, Sean MACKAY, Colin NG, Patrick PACZKOWSKI, Sean MCCUSKER, Igor NIKONOROV, Alaina KAISER
Filed: 21 Nov 17
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