13 patents
Utility
Polymerase enzyme from 9°N
9 Jan 24
The present invention relates to a polymerase enzyme from 9° N with improved ability to incorporate reversibly terminating nucleotides.
Jerzy Olejnik, Angela Delucia
Filed: 17 Jun 21
Utility
DNA sequencing reaction additive
21 Nov 23
The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3′-O position capped by a disulfide-based 3′-terminator group are used.
Luisa Andruzzi, Jimmy Adediran, Timothy Pelletier, Austin Ricker, Angela DeLucia, Ben McNally, Dona Hevroni, Mong Sano Marma, John Andrew Sheridan
Filed: 21 Aug 20
Utility
Analysis and screening of cell secretion profiles
30 May 23
Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components.
Patrick Paczkowski, Sean Mackay, Sean McCusker
Filed: 10 Jun 21
Utility
Methods of using nucleotide analogues
10 Jan 23
The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside.
Mong Sano Marma, Jerzy Olejnik, Ilia Korboukh
Filed: 22 Mar 18
Utility
Systems, devices and methods for cell capture and methods of manufacture thereof
13 Dec 22
Embodiments of the current disclosure are directed to systems, methods and apparatus for evaluating single cell secretion profiles.
Peter Tsiomplikas, Jerry Sedgewick, Jeffrey Whynall, Sean MacKay, Colin Ng, Patrick Paczkowski, Sean McCusker, Igor Nikonorov, Alaina Kaiser
Filed: 22 Nov 17
Utility
Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
8 Nov 22
Disclosed are compositions and methods for the multiplexed analysis of one or more intracellular targets of a single cell.
Colin Ng, Alaina Kaiser, Emily Bettini, Patrick Paczkowski, Sean Mackay, Feimei Liu, Maithreyan Srinivasan
Filed: 13 Nov 17
Utility
Thiol-containing cleave reagents and oxidative wash
23 Aug 22
The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside.
Mong Sano Marma, Luisa Andruzzi, Ben McNally, Angela DeLucia, Dona Hevroni, Elizabeth Carpenter, Magnus Besev
Filed: 13 Mar 17
Utility
Photoprotective mixtures as imaging reagents in sequencing-by-synthesis
2 Nov 21
The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods.
Luisa Andruzzi, Michel Georges Perbost, Dona Hevroni, Minakshi Guha, Austin Ricker, Timothy Pelletier
Filed: 31 Oct 17
Utility
Methods and devices for amplification of nucleic acid
19 Oct 21
The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions.
Steven Gordon, Daniel Stetson
Filed: 5 Sep 17
Utility
Methods for synthesizing nucleotide analogues with disulfide linkers
14 Sep 21
The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside.
Mong Sano Marma, Jerzy Olejnik, Ilia Korboukh
Filed: 28 May 19
Utility
Polyphenolic additives in sequencing by synthesis
3 Aug 21
The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis methods.
Jerzy Olejnik, Michel Georges Perbost
Filed: 24 May 19
Utility
Analysis and screening of cell secretion profiles
20 Jul 21
Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components.
Patrick Paczkowski, Sean MacKay, Sean McCusker
Filed: 27 Jan 20
Utility
Analysis and screening of cell secretion profiles
9 Mar 20
Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components.
Patrick Paczkowski, Sean MacKay, Sean McCusker
Filed: 2 Dec 15
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