159 patents
Page 3 of 8
Utility
Laboratory Automation System Implementing Efficient Path for Material and Labware Transfers
18 Aug 22
Systems, methods and computer-readable media are provided for determining a sequential ordering of predefined transfers for transferring an object from source points of a source array to destination points of a destination array in a laboratory automation system.
Christopher Bremner
Filed: 26 Jun 20
Utility
Manipulation of Genes Involved In Signal Transduction to Control Fungal Morphology During Fermentation and Production
18 Aug 22
The present disclosure provides a microbial genomic engineering method and system for transforming, screening, and selecting filamentous fungal cells that have altered morphology and/or growth under specific growth conditions.
Kenneth S. BRUNO, Sachin JAIN, Brandon PFANNENSTIEL, Edyta SZEWCZYK
Filed: 21 Mar 22
Utility
Microbial Engineering Methods and Systems for Optimizing Microbe Fitness
21 Jul 22
The present disclosure provides a microbe engineering platform that permits optimization of microbe fitness levels to optimize a microbe's suitability for industrial fermentation.
WILLIAM SERBER, ERIK JEDEDIAH DEAN
Filed: 6 Dec 21
Utility
HTP genomic engineering platform
7 Jun 22
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 7 May 21
Utility
Engineered Biosynthetic Pathways for Production of L-homocysteine by Fermentation
26 May 22
The present disclosure describes the engineering of microbial cells for fermentative production of L-homocysteine and provides novel engineered microbial cells and cultures, as well as related L-homocysteine production methods.
Michael Shareef Siddiqui, Alexander Glennon Shearer, Franklin Lu, Stefan de Kok, Cara Ann Tracewell, Steven M. Edgar, Jennifer Yip
Filed: 24 Mar 20
Utility
HTP Genomic Engineering Platform for Improving Fungal Strains
12 May 22
A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided.
Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
Filed: 26 Jan 22
Utility
Systems and methods for host cell improvement utilizing epistatic effects
26 Apr 22
The present disclosure provides systems and methods for host cell improvement utilizing epistatic effects.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 12 May 21
Utility
Promoters from
5 Apr 22
Provided are native promoters comprising polynucleotides isolated from Corynebacterium glutamicum, and mutant promoters derived therefrom, which may be used to regulate, i.e., either increase or decrease, gene expression.
Zachariah Serber, Katherine G. Gora, Shawn P. Manchester
Filed: 7 Dec 16
Utility
Polymer Compositions Comprising Compounds Derived from Biology
31 Mar 22
A compound comprises a moiety selected from a cyclic dimer of a first and a second amino acid or a 2.5-diketopiperazine made from an amino acid.
John J. McNamara, Carol A. Koch, Michael William Angus MacLean, Stephen Lo, Ke Li, Jason P. Safko, Md Nazim Uddin, Jenny Shao, Joachim C. Ritter
Filed: 30 Dec 19
Utility
Elastomeric Adhesives Comprising Bio-derived Compounds
31 Mar 22
The present disclosure addresses elastomeric adhesives and elastomers that include a modified amine.
Nandita Bhagwat, John Dickens, Joachim C. Ritter, Gerald A. Vandezande, Jonathon E. Vandezande, John J. McNamara
Filed: 21 Jan 20
Utility
Iterative genome editing in microbes
22 Mar 22
The present invention relates to methods for editing the genome of a microbial host cell in successive rounds of transformation.
Stephen Blaskowski, Sara da Luz Areosa Cleto, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 27 May 21
Utility
Microbial Strain Design System and Methods for Improved Large-scale Production of Engineered Nucleotide Sequences
10 Mar 22
The generation of a factory order includes receiving an expression indicating an operation on a first sequence operand and a second sequence operand.
Barbara Frewen, Aaron Kimball
Filed: 16 Sep 21
Utility
HTP genomic engineering platform for improving fungal strains
8 Feb 22
A HTP genomic engineering platform for improving filamentous fungal cells that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols is provided.
Vytas SunSpiral, Jennifer Fredlund, Hassan Abdulla, Paolo Boccazzi, Sean Poust, Sara da Luz Areosa Cleto, Brian Chaikind, Dylan Vaughan, Kenneth S. Bruno, Patrick Westfall, Edyta Szewczyk, Kyle Rothschild-Mancinelli, Arthur Muir Fong, III
Filed: 19 Mar 21
Utility
Engineered Biosynthetic Pathways for Production of 1,5-DIAMINOPENTANE by Fermentation
3 Feb 22
The present disclosure describes the engineering of microbial cells for fermentative production of 1,5-diaminopentane and provides novel engineered microbial cells and cultures, as well as related 1,5-diaminopentane production methods.
Aaron Miller, Zhihao Wang, Jeffrey Mellin, Murtaza Shabbir Hussain, Steven M. Edgar
Filed: 21 Nov 19
Utility
Engineered Biosynthetic Pathways for Production of 2-OXOADIPATE by Fermentation
3 Feb 22
The present disclosure describes the engineering of microbial cells for fermentative production of 2-oxoadipate and provides novel engineered microbial cells and cultures, as well as related 2-oxoadipate production methods.
Anupam Chowdhury, Steven M. Edgar, Alexander Glennon Shearer, Cara Ann Tracewell, Stepan Tymoshenko, Zhihao Wang
Filed: 25 Nov 19
Utility
Systems and Methods for High-throughput Automated Strain Generation for Non-sporulating Fungi
3 Feb 22
Embodiments disclosed include systems and methods to generate and/or improve non-sporulating filamentous fungal cells using high-throughput techniques.
Benjamin Knox, Nasim Mansoori Zangir, Ryan Evan Martinez, Hassan Abdulla
Filed: 28 Jul 21
Utility
Bioreachable Chiral Dopants for Liquid Crystal Applications
27 Jan 22
The disclosure discusses chiral dopants for liquid-crystalline materials.
Adam Safir, Shilpa Naresh Raja, Arjan Zoombelt, Robert J. Twieg, Pawan Nepal, Ashani Wedige-Fernando, Peter Palffy-Muhoray
Filed: 6 Dec 19
Utility
Microbial engineering methods and systems for optimizing microbe fitness
18 Jan 22
The present disclosure provides a microbe engineering platform that permits optimization of microbe fitness levels to optimize a microbe's suitability for industrial fermentation.
William Serber, Erik Jedediah Dean
Filed: 4 May 18
Utility
Metagenomic Library and Natural Product Discovery Platform
6 Jan 22
The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs).
Oliver LIU, Eyal AKIVA, Tom Hayon EYLES, Ute GALM, Sangita GANESH, Stephanie Leanne Brown HENDRIX, William W. HWANG, Jeffrey Hoon KIM, Alexander NECKELMANN, Samuel OTENG-PABI, Claus PELIKAN, Devin SCANNELL, Zachariah SERBER, Jennifer SHOCK, Michael W. SNEDDON, Xiao YANG
Filed: 21 Sep 21
Utility
HTP genomic engineering platform
28 Dec 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 5 May 21