159 patents
Page 5 of 8
Utility
HTP Genomic Engineering Platform
26 Aug 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah SERBER, Erik Jedediah DEAN, Shawn MANCHESTER, Katherine GORA, Michael FLASHMAN, Erin SHELLMAN, Aaron KIMBALL, Shawn SZYJKA, Barbara FREWEN, Thomas TREYNOR, Kenneth S. BRUNO
Filed: 7 May 21
Utility
Liquid based selection and cell isolation
24 Aug 21
Aspects of this disclosure relate to liquid-based workflows for strain engineering.
Sean Poust, Vytas SunSpiral, William Serber, Matthew Jonathan Myers, Sara da Luz Areosa Cleto, Philip Weyman
Filed: 2 Jul 19
Utility
Modular universal plasmid design strategy for the assembly and editing of multiple DNA constructs for multiple hosts
24 Aug 21
Methods, compositions, and kits for high throughput DNA assembly reactions in vitro.
Brian Chaikind, Hendrik Marinus van Rossum
Filed: 8 Aug 19
Utility
HTP Platform for the Genetic Engineering of Chinese Hamster Ovary Cells
19 Aug 21
Presented herein is a high-throughput (HTP) genomic engineering platform for improving the production of therapeutic proteins in Chinese hamster ovary (CHO) cells.
Kate CAVES, Amarjeet SINGH
Filed: 23 Apr 21
Utility
Manipulation of Genes Involved In Signal Transduction to Control Fungal Morphology During Fermentation and Production
19 Aug 21
The present disclosure provides a microbial genomic engineering method and system for transforming, screening, and selecting filamentous fungal cells that have altered morphology and/or growth under specific growth conditions.
Kenneth S. BRUNO, Sachin JAIN, Brandon PFANNENSTIEL, Edyta SZEWCZYK
Filed: 30 Apr 21
Utility
Methods and Systems for the Optimization of a Biosynthetic Pathway
19 Aug 21
The present disclosure provides methods and systems for identifying variants of a given target protein or target gene that perform the same function and/or improve the phenotypic performance of a host cell transformed with such a variant.
Stepan TYMOSHENKO, Oliver LIU
Filed: 12 Feb 21
Utility
Metagenomic Library and Natural Product Discovery Platform
19 Aug 21
The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs).
Oliver LIU, Eyal AKIVA, Tom Hayon EYLES, Ute GALM, Sangita GANESH, Stephanie Leanne Brown HENDRIX, William W. HWANG, Jeffrey Hoon KIM, Alexander NECKELMANN, Samuel OTENG-PABI, Claus PELIKAN, Devin SCANNELL, Zachariah SERBER, Jennifer SHOCK, Michael SNEDDON, Xiao YANG
Filed: 16 Feb 21
Utility
Systems and methods for host cell improvement utilizing epistatic effects
10 Aug 21
The present disclosure provides systems and methods for host cell improvement utilizing epistatic effects.
Zachariah Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 28 Oct 19
Utility
HTP Engineering Platform
22 Jul 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah SERBER, Erik Jedediah DEAN, Shawn MANCHESTER, Katherine GORA, Michael FLASHMAN, Erin SHELLMAN, Aaron KIMBALL, Shawn SZYJKA, Barbara FREWEN, Thomas TREYNOR, Kenneth S. BRUNO
Filed: 22 Mar 21
Utility
Bioreachable Prediction Tool with Biological Sequence Selection
22 Jul 21
Systems, methods and non-transitory computer-readable media identify a candidate biological sequence for enabling a function in a host cell.
Anupam Chowdhury, Alexander Glennon Shearer, Stepan Tymoshenko, Michelle L. Wynn, Erik Jedediah Dean
Filed: 14 Aug 19
Utility
Multiplexed deterministic assembly of DNA libraries
20 Jul 21
The present disclosure relates to methods of joining three or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro or in vivo.
Erik Jedediah Dean, Kedar Patel, Aaron Miller, Kunal Mehta, Philip Weyman
Filed: 31 Oct 19
Utility
Monothioether Crosslinkers In Polymers and Applications Thereof
8 Jul 21
John McNamara, Nicole G. Ricapito, Timothy J. Deming, Eric G. Gharakhanian
Filed: 30 May 19
Utility
Iterative genome editing in microbes
6 Jul 21
The present invention relates to methods for editing the genome of a microbial host cell in successive rounds of transformation.
Stephen Blaskowski, Sara da Luz Areosa Cleto, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 20 Mar 20
Utility
Pooled genome editing in microbes
6 Jul 21
The present invention relates to methods for editing the genome of a microbial host cell in one or more rounds of transformation.
Stephen Blaskowski, Sara da Luz Areosa Cleto, Cameron Coates, Aaron Miller, Sharon Nademanee, Melissa Netwal, Kedar Patel, Shawn Szyjka, Philip Weyman, Solomon Henry Stonebloom, Colin Scott Maxwell, Elizabeth Lauren Meier
Filed: 20 Mar 20
Utility
Insecticidal protein discovery platform and insecticidal proteins discovered therefrom
29 Jun 21
The disclosure presents a platform for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
William W. Hwang, Jeffrey Kim, Oliver Liu, Jennifer Shock
Filed: 1 Sep 20
Utility
Engineered Biosynthetic Pathways for Production of Histamine by Fermentation
17 Jun 21
The present disclosure describes the engineering of microbial cells for fermentative production of histamine and provides novel engineered microbial cells and cultures, as well as related histamine production methods.
Cara Ann Tracewell, Alexander Glennon Shearer, Michael Shareef Siddiqui, Steven M. Edgar, Nicolaus Herman, Murtaza Shabbir Hussain
Filed: 19 Apr 19
Utility
Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production
8 Jun 21
The present disclosure provides a microbial genomic engineering method and system for transforming, screening, and selecting filamentous fungal cells that have altered morphology and/or growth under specific growth conditions.
Kenneth S. Bruno, Sachin Jain, Brandon Pfannenstiel, Edyta Szewczyk
Filed: 6 Jun 19
Utility
Engineered biosynthetic pathways for production of tyramine by fermentation
8 Jun 21
The present disclosure describes the engineering of microbial cells for fermentative production of tyramine and provides novel engineered microbial cells and cultures, as well as related tyramine production methods.
Michael Shareef Siddiqui, Stefan de Kok, Alexander Glennon Shearer, Franklin Lu, Cara Ann Tracewell, Steven M. Edgar
Filed: 26 Jun 19
Utility
Method for creating a genomic library enriched for
18 May 21
The disclosure is directed to an approach for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
Jeffrey Kim, Oliver Liu, Jennifer Shock, Maritza Duarte
Filed: 20 Aug 20
Utility
HTP platform for the genetic engineering of Chinese hamster ovary cells
27 Apr 21
Presented herein is a high-throughput (HTP) genomic engineering platform for improving the production of therapeutic proteins in Chinese hamster ovary (CHO) cells.
Kate Caves, Amarjeet Singh
Filed: 20 Jul 20