31 patents
Utility
Synthetic Methanol Inducible Promoters and Uses Thereof
4 Jan 24
This application describes synthetic promoters capable of facilitating the high-yield synthesis of proteins and molecules.
Swaminath Srinivas, Justin Michael Gardin
Filed: 12 Nov 21
Utility
Adeno-associated Viral Vectors for Treatment of Niemann-pick Disease Type C
7 Dec 23
Provided herein are gene therapy compositions and methods for treating, preventing, and/or curing NPC1.
Daniel MCCOY, Garrett BERRY, David DISMUKE
Filed: 16 Oct 20
Utility
Methods and Systems for Chemoautotrophic Production of Organic Compounds
30 Nov 23
The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
Curt R. Fischer, Austin J. Che, Reshma P. Shetty, Jason R. Kelly
Filed: 31 May 23
Utility
Methods and Compositions Involving Promoters Derived from Yarrowia Lipolytica
9 Nov 23
The current methods and compositions provide for nucleotide sequences of promoters from Yarrowia lipolytica which may be used to drive gene expression in a cell.
Vasiliki TSAKRAKLIDES, Annapurna KAMINENI
Filed: 27 Dec 22
Utility
Biosynthesis of Cannabinoids and Cannabinoid Precursors
26 Oct 23
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
Kim Cecelia Anderson, Brian Carvalho, Nicholas Flores, Seth Ritter, Gabriel Rodriguez, Michelle Spencer, Emily E. Wrenbeck
Filed: 17 Jun 21
Utility
VARIANT SARS-CoV-2 PROTEINS AND USES THEREOF
28 Sep 23
The present disclosure relates to variants of SARS-CoV-2 nucleocapsid protein, spike protein, and spike protein receptor binding domain (RBD), as well as nucleic acids encoding such variants and methods of use thereof.
Ariel H. HECHT, Seth C. Ritter, Emily E. Wrenbeck
Filed: 5 May 21
Utility
Synthetic Expression Systems
17 Aug 23
This application describes transcriptional units, synthetic expression systems, and host cells comprising transcriptional units and synthetic expression systems, wherein the synthetic expression system is capable of expressing a gene of interest.
Nikos Reppas, Swaminath Srinivas, Adam Meyer, Alex Tucker, Punita Manga, Sneha Srikrishnan
Filed: 5 Sep 21
Utility
Biosynthesis of Cannabinoids and Cannabinoid Precursors
4 May 23
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
Kim Cecelia Anderson, Jeffrey lan Boucher, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Gabriel Rodriguez, Michelle Spencer
Filed: 26 Mar 21
Utility
Methods and Systems for Methylotrophic Production of Organic Compounds
6 Apr 23
The present disclosure identifies pathways, mechanisms, systems and methods to confer production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in engineered and/or evolved methylotrophs such that these organisms efficiently convert C1 compounds, such as formate, formic acid, formaldehyde or methanol, to organic carbon-based products of interest, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
Reshma P. Shetty, Curt R. Fischer
Filed: 30 Sep 22
Utility
Recombinant Bacteria Engineered to Treat Diseases Associated with Methionine Metabolism and Methods of Use Thereof
2 Mar 23
The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject.
Dylan Alexander Carlin, Vincent M. Isabella, Jonathan McMurry, Theodore Carlton Moore, III, Mylene Perreault, Seth Ritter, Nathan Schmidt, Mark Simon
Filed: 11 Aug 22
Utility
Enhanced Production of Histidine, Purine Pathway Metabolites, and Plasmid Dna
2 Mar 23
Aspects of the disclosure relate to biosynthesis of histidine in host cells.
Alkiviadis Orfefs Chatzivasileiou, Jason King, Huey-Ming Mak, Gabriel Rodriguez, Emily E. Wrenbeck, David Young
Filed: 16 Dec 20
Utility
Biosynthesis of Mogrosides
1 Dec 22
The disclosure relates to enzymes, such as cucurbitadienol synthase (CDS), UDP-glycosyltransferase (UGT), C11 hydroxylase, epoxide hydrolase (EPH), squalene epoxidase (SQE), and/or cytochrome P450 reductase enzymes, recombinant host cells expressing the enzymes, and methods of producing mogrol precursors, mogrol, and/or mogrosides using such recombinant cells.
Jeffrey Ian Boucher, Matthew McMahon, Scott Marr, Jie Zhu
Filed: 23 Oct 20
Utility
Diacylglycerol Acyltransferase (DGA1) Polynucleotides, and Methods of Increasing Yeast Cell Lipid Production by Overexpression of Heterologous DGA1
1 Dec 22
DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast.
Elena E. Brevnova, Arthur J. Shaw, IV, Emily H. Greenhagen
Filed: 6 Jun 22
Utility
Production of Oligosaccharides
24 Nov 22
The disclosure relates to methods and compositions for the production of fructans using sucrose:sucrose 1-fructosyl-transferase (1-SST), fructan:fructan 1-fructosyltransferase (1-FFT), and/or sucrose fructan-6-fructosyltransferase (6-SFT) enzymes.
Sudeep Agarwala, Michael G. Napolitano
Filed: 24 Sep 20
Utility
Optimized Bacteria Engineered to Treat Disorders Involving the Catabolism of Leucine, Isoleucine, And/or Valine
17 Nov 22
The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patients internal environment and respond by turning an engineered metabolic pathway on or off.
Ning Li, Jian-Rong Gao, Philippa Jane Reeder Morrison, Christopher George Bergeron, Dylan Alexander Carlin, Laura K. Stone, Alex C. Tucker, Patrick M. Boyle
Filed: 19 Jun 20
Utility
Rare Earth Element (Ree)-binding Proteins
3 Nov 22
Described in this disclosure are rare earth element (REE)-binding proteins (e.g., lanthanide-binding proteins), host cells expressing the REE-binding proteins, and methods of recovering REEs.
Patrick Boyle, Ramya L. Prathuri, Nathan W. Schmidt, Emily E. Wrenbeck, Mark David Simon
Filed: 19 Jun 20
Utility
Protective Enzymes
3 Nov 22
The present invention relates to methods and compositions that include enzymes and/or binding polypeptides useful for protecting polymers from damage caused by fatty acids from secreted biological fluids such as sebum or sweat.
Patrick Magannig Boyle, Jeffery Ian Boucher, Michael Gregory Napolitano
Filed: 13 May 22
Utility
Biosynthesis of Enzymes for Use In Treatment of Maple Syrup Urine Disease (Msud)
3 Nov 22
Provided in this disclosure, in some embodiments, are methods and compositions for treating maple syrup urine disease (MSUD) and other conditions characterized by excessive branched-chain amino acids.
Patrick Boyle, Dylan Alexander Carlin, Rishi Jain, Ryan Putman, Laura Stone, Alex C. Tucker, Kolea Zimmerman
Filed: 19 Jun 20
Utility
Heterologous Production of 10-METHYLSTEARIC Acid by Cells Expressing Recombinant Methyltransferase
27 Oct 22
Disclosed herein are cells, nucleic acids, and proteins that can be used to produce branched (methyl)lipids, such as 10-methylstearic acids, and compositions that include such lipids.
Arthur J. Shaw, Hannah Blitzblau, Donald V. Crabtree
Filed: 30 Jan 22
Utility
Biosynthesis of Cannabinoids and Cannabinoid Precursors
29 Sep 22
The disclosure relates to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro comprising the use of disclosed prenyltransferase variants.
Kim Cecelia Anderson, Dylan Alexander Carlin, Nicholas Flores, Katrina Forrest, Ramya L. Prathuri, Gabriel Rodriguez, Michelle Spencer
Filed: 18 Aug 20