18 patents
Utility
Recombinant bacteria engineered to treat diseases associated with methionine metabolism and methods of use thereof
2 Jan 24
The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject.
Dylan Alexander Carlin, Vincent M. Isabella, Jonathan McMurry, Theodore Carlton Moore, III, Mylene Perreault, Nathan Schmidt, Mark Simon
Filed: 11 Aug 22
Utility
Unknown
18 Jul 23
Signal sequences useful for targeting proteins and peptides to the surface of endospores produced by Paenibacillus family members and methods of using the same are provided.
Damian Curtis, Benjamin L. Golomb, Dilara Ally, Florencia A. Ficarra, Rauf Salamzade, Bjorn A. Traag
Filed: 30 Mar 21
Utility
Chemoautotrophic cells comprising an engineered carbon fixation pathway
11 Jul 23
The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
Curt R. Fischer, Austin J. Che, Reshma P. Shetty, Jason R. Kelly
Filed: 30 Jul 20
Utility
Oleic acid production in yeast
25 Apr 23
Disclosed are transformed cells comprising one or more genetic modifications that affect the lipid content of the cell, e.g., by increasing the concentration of oleic acid in the cell relative to an unmodified cell of the same type.
Vasiliki Tsakraklides, Elena E. Brevnova, Jonathan Friedlander, Annapurna Kamineni, Arthur J. Shaw, IV
Filed: 9 Dec 15
Utility
Methods and compositions involving promoters derived from Yarrowia lipolytica
7 Feb 23
The current methods and compositions provide for nucleotide sequences of promoters from Yarrowia lipolytica which may be used to drive gene expression in a cell.
Vasiliki Tsakraklides, Annapurna Kamineni
Filed: 29 Jul 20
Utility
Microorganisms engineered to use unconventional sources of phosphorous or sulfur
27 Dec 22
Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical phosphorus or sulfur sources.
Arthur J. Shaw, IV, Colin R. South, Johannes P. Van Dijken
Filed: 27 Nov 18
Utility
Increasing lipid production in oleaginous yeast
8 Nov 22
Disclosed are methods and compositions for increasing the triacylglycerol content of a cell by increasing the activity of a type 1 diacylglycerol acyltransferase (i.e., DGA2) and increasing the activity of a type 2 diacylglycerol acyltransferase (i.e., DGA1).
Vasiliki Tsakraklides, Elena E. Brevnova
Filed: 5 Apr 19
Utility
Methods and systems for methylotrophic production of organic compounds
25 Oct 22
The present disclosure identifies pathways, mechanisms, systems and methods to confer production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in engineered and/or evolved methylotrophs such that these organisms efficiently convert C1 compounds, such as formate, formic acid, formaldehyde or methanol, to organic carbon-based products of interest, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
Reshma P. Shetty, Curt R. Fischer
Filed: 27 Mar 18
Utility
Compositions and methods for the production of compounds
25 Oct 22
The present disclosure provides proteins, nucleic acids, vectors, and host molecules useful for the production of compounds of interest, and methods for their use.
Daniel C. Gray, Brian R. Bowman, Gregory L. Verdine, Mathew Edward Sowa
Filed: 27 Oct 17
Utility
Compositions and methods for the production of compounds
20 Sep 22
The present disclosure provides nucleic acids encoding a Large ATP-binding regulator of the LuxR family (LAL) of transcription factors, vectors and host cells including such nucleic acids, and methods for producing compounds (e.g., polyketides or β-lactam compounds) with such nucleic acids, vectors, and/or host cells.
Brian R. Bowman, Joshua A. V. Blodgett, Gregory L. Verdine, Daniel C. Gray, Jay P. Morgenstern, Lucy Foulston, Keith Robison
Filed: 29 Jan 21
Utility
Protective enzymes
14 Jun 22
The present invention relates to methods and compositions that include enzymes and/or binding polypeptides useful for protecting polymers from damage caused by fatty acids from secreted biological fluids such as sebum or sweat.
Patrick Magannig Boyle, Jeffrey Ian Boucher, Michael Gregory Napolitano
Filed: 12 Sep 18
Utility
Diacylglycerol acyltransferase (DGA1) polynucleotides, and methods of increasing yeast cell lipid production by overexpression of heterologous DGA1
7 Jun 22
DGA1 catalyzes the final enzymatic step for converting acyl-CoA and 1,2-diacylglycerol to triacylglycerols (TAG) and CoA in yeast.
Elena E. Brevnova, Arthur J. Shaw, IV, Emily H. Greenhagen
Filed: 28 Feb 19
Utility
Biosynthesis of cannabinoids and cannabinoid precursors
15 Mar 22
Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
Kim Cecelia Anderson, Elena Brevnova, Dylan Alexander Carlin, Brian Carvalho, Nicholas Flores, Katrina Forrest, Massimo Merighi, Gabriel Rodriguez, Emily E. Wrenbeck
Filed: 23 Oct 20
Utility
Heterologous production of 10-methylstearic acid by cells expressing recombinant methyltransferase
1 Feb 22
Disclosed herein are cells, nucleic acids, and proteins that can be used to produce branched (methyl)lipids, such as 10-methylstearic acids, and compositions that include such lipids.
Arthur J. Shaw, Hannah Blitzblau, Donald V. Crabtree
Filed: 20 Sep 18
Utility
Microorganisms engineered to use unconventional sources of nitrogen
22 Jun 21
Disclosed are genetically engineered organisms, such as yeast and bacteria, that have the ability to metabolize atypical nitrogen sources, such as melamine and cyanamide.
Colin R. South, Arthur J. Shaw, IV
Filed: 23 Apr 19
Utility
Heterologous production of 10-methylstearic acid
13 Apr 21
Nucleic acids and cells comprising a methyltransferase gene and/or a reductase gene are disclosed.
Arthur J. Shaw, Hannah Blitzblau, Donald V. Crabtree
Filed: 25 Oct 19
Utility
Compositions and methods for the production of compounds
2 Feb 21
The present disclosure provides nucleic acids encoding a Large ATP-binding regulator of the LuxR family (LAL) of transcription factors, vectors and host cells including such nucleic acids, and methods for producing compounds (e.g., polyketides or β-lactam compounds) with such nucleic acids, vectors, and/or host cells.
Brian R. Bowman, Joshua A. V. Blodgett, Gregory L. Verdine, Daniel C. Gray, Jay P. Morgenstern, Lucy Foulston, Keith Robison
Filed: 12 Apr 17
Utility
Methods for making chemoautotrophic cells by engineering an energy conversion pathway and a carbon fixation pathway
12 Oct 20
The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
Curt R. Fischer, Austin J. Che, Reshma P. Shetty, Jason R. Kelly
Filed: 9 Jan 18
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