28 patents
Utility
Modified Adenoviruses
21 Dec 23
Compositions include modified adenoviruses.
Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
Filed: 4 Jan 23
Utility
Antigen-binding Proteins Targeting Shared Antigens
30 Nov 23
Provided herein are HLA-PEPTIDE targets and antigen binding proteins that bind HLA-PEPTIDE targets.
Karin Jooss, Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Michele Anne Busby, Joshua Michael Francis, Gijsbert Marnix Grotenbreg, Mojca Skoberne, Roman Yelensky
Filed: 13 Dec 22
Utility
SARS-COV-2 Vaccines
19 Oct 23
Disclosed herein are vaccine compositions that include SARS-CoV-2 MHC epitope-encoding cassettes and/or full-length SARS-CoV-2 proteins.
Roman Yelensky, Minh Duc Cao, Mike Zhong, Justin Helbert, Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin, Amy Rachel Rappaport
Filed: 18 Nov 22
Utility
Antigen-encoding Cassettes
5 Oct 23
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple repeats of distinct epitope-encoding sequences or having antigen-encoding nucleic acid sequences having less than 700 nucleotides and encoding multiple distinct epitope-encoding sequences.
Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
Filed: 20 Oct 22
Utility
Capping Compounds, Compositions and Methods of Use Thereof
28 Sep 23
The present disclosure includes, among other things, non-natural nucleotides useful as 5′ caps for RNA nucleotides.
Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Sue-Jean Hong, Arvin Akoopie
Filed: 20 Oct 22
Utility
Antigen-binding Proteins and Related Methods of Use
21 Sep 23
Provided herein are antigen binding proteins (ABPs) that bind HLA-PEPTIDE targets.
Godfrey Jonah Anderson Rainey, Karin Jooss, Roman Yelensky, Wade Blair, Heungnam Kim, Christine Janson, Anne Van Abbema, Isaac J. Rondon
Filed: 14 Apr 23
Utility
Antigen-binding Proteins Targeting KKLC-1 Shared Antigen
14 Sep 23
Provided herein are antigen binding proteins that selectively bind a particular KKLC-1 shared antigen, as well as related methods, kits, and compositions.
Godfrey Jonah Anderson Rainey, Karin Jooss, Manankumar Anilkumar Shah
Filed: 17 Aug 22
Utility
Hiv Antigens and MHC Complexes
27 Apr 23
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides.
Roman Yelensky, James Xin Sun, Joshua Klein, Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
Filed: 3 Aug 22
Utility
Cell-free Dna Monitoring
6 Apr 23
Methods and compositions for monitoring mutation burden, cancer status, vaccine efficacy using cell-free DNA sequencing are disclosed.
James Xin Sun, Matthew Joseph Davis, Desiree Schenk, Daniel Navarro Gomez
Filed: 8 Jul 22
Utility
Durable Vaccination
16 Feb 23
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides.
Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
Filed: 10 Jun 22
Utility
Antigen-binding Proteins Targeting Shared Neoantigens
9 Feb 23
Provided herein are target HLA-PEPTIDE antigens, e.g., HLA-PEPTIDE neoantigens and shared tumor HLA-PEPTIDE antigens, and antigen binding proteins (ABPs) that bind the target HLA-PEPTIDE antigens.
Karin Jooss, Aleksandra Katarzyna Nowicka, Abubakar Jalloh, Roman Yelensky, James Xin Sun, Jennifer Busby, Matthew Joseph Davis
Filed: 13 May 22
Utility
Shared Neoantigen Vaccines
19 Jan 23
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides.
Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Jennifer Busby, Brendan Bulik-Sullivan, Mojca Skoberne, Wade Blair
Filed: 4 May 22
Utility
Multiepitope Vaccine Cassettes
25 Aug 22
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences having multiple iterations of KRAS neoepitope-encoding sequences and/or lacking immunodominant epitopes.
Karin Jooss, Roman Yelensky, James Xin Sun, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer, Monica Lane
Filed: 22 Apr 22
Utility
Hiv Antigens and MHC Complexes
25 Aug 22
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides.
Roman Yelensky, James Xin Sun, Joshua Klein, Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
Filed: 29 Dec 21
Utility
Alphavirus Antigen Vectors
21 Jul 22
Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject.
Wade Blair, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin
Filed: 11 Mar 22
Utility
Multispecific Binding Proteins
26 May 22
Provided herein are HLA-PEPTIDE targets and multispecific antigen binding proteins that bind HLA-PEPTIDE targets.
Karin Jooss, Godfrey Jonah Anderson Rainey, Wade Blair, Michele Anne Busby, Gijsbert Marnix Grotenbreg, Roman Yelensky, Shan Liu Hwang, Gayatri Prakash
Filed: 29 Jan 20
Utility
Neoantigen Identification Using Hotspots
12 May 22
A method for identifying neoantigens that are likely to be presented on a surface of tumor cells of a subject.
Brendan Bulik-Sullivan, Thomas Francis Boucher, Roman Yelensky
Filed: 21 Jan 22
Utility
Alphavirus Neoantigen Vectors and Interferon Inhibitors
28 Apr 22
Disclosed herein are vectors that include alphavirus-based expression platforms.
Karin Jooss, Amy Rachel Rappaport, Leonid Gitlin
Filed: 7 Nov 19
Utility
Modified Adenoviruses
24 Mar 22
Disclosed herein are compositions that include modified adenoviruses.
Karin Jooss, Ciaran Daniel Scallan, Leonid Gitlin
Filed: 30 Nov 21
Utility
Neoantigen Identification, Manufacture, and Use
22 Apr 21
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Thomas Boucher, Brendan Bulik-Sullivan, Jennifer Busby, Roman Yelensky
Filed: 19 Apr 18