28 patents
Page 2 of 2
Utility
Neoantigen Identification, Manufacture, and Use
1 Apr 21
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Roman Yelensky, Adnan Derti, Brendan Bulik-Sullivan, Jennifer Busby
Filed: 23 Nov 20
Utility
Antigen-Binding Proteins Targeting Shared Antigens
4 Mar 21
Provided herein are HLA-PEPTIDE targets and antigen binding proteins that bind HLA-PEPTIDE targets.
Karin Jooss, Wade Blair, Brendan Bulik-Sullivan, Michele Anne Busby, Jennifer Busby, Joshua Michael Francis, Gijsbert Marnix Grotenbreg, Mojca Skoberne, Roman Yelensky
Filed: 28 Dec 18
Utility
Reducing Junction Epitope Presentation for Neoantigens
14 Jan 21
Given a set of therapeutic epitopes, a cassette sequence is designed to reduce the likelihood that junction epitopes are presented in the patient.
Brendan Bulik-Sullivan, Thomas Francis Boucher, Roman Yelensky, Jennifer Busby
Filed: 21 Nov 18
Utility
Neoantigen Identification with Pan-Allele Models
30 Dec 20
A method for identifying neoantigens that are likely to be presented by MHC alleles on a surface of tumor cells of a subject.
Thomas Francis Boucher, Brendan Bulik-Sullivan, Jennifer Busby, Mojca Skoberne, Roman Yelensky
Filed: 26 Feb 19
Utility
Neoantigen Identification for T-Cell Therapy
18 Nov 20
A method for identifying T-cells that are antigen-specific for at least one neoantigen that is likely to be presented on surfaces of tumor cells of a subject.
Roman Yelensky, Brendan Bulik-Sullivan, Jennifer Busby, Matthew Joseph Davis, Lauren Elizabeth Young, Joshua Michael Francis, Christine Palmer, Mojca Skoberne
Filed: 4 Sep 18
Utility
Alphavirus Neoantigen Vectors
24 Jun 20
Disclosed herein are alphavirus vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject.
Wade BLAIR, Karin JOOSS, Amy Rachel RAPPAPORT, Ciaran Daniel SCALLAN, Leonid GITLIN
Filed: 7 May 18
Utility
Neoantigen Identification, Manufacture, and Use
1 Apr 20
Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as determined on the basis of an individual's tumor mutations.
Brendan Bulik-Sullivan, Roman Yelensky, Jennifer Busby, Adnan Derti
Filed: 7 Jun 18
Utility
Viral Delivery of Neoantigens
8 Jan 20
Disclosed herein are chimpanzee adenoviral vectors that include neoantigen-encoding nucleic acid sequences derived from a tumor of a subject.
Wade Blair, Brendan Bulik-Sullivan, Jennifer Busby, Adnan Derti, Leonid Gitlin, Gijsbert Grotenbreg, Karin Jooss, Ciaran Daniel Scallan, Roman Yelensky
Filed: 21 Nov 17