5 patents
Utility
Liquid Pharmaceutical Composition Comprising Ensifentrine and Glycopyrrolate
13 Apr 23
The present invention relates to a liquid pharmaceutical composition suitable for administration by inhalation comprising: (i) ensifentrine particles; (ii) glycopyrrolate; and (iii) a diluent, which diluent comprises water, wherein: the glycopyrrolate is dissolved in the diluent; the concentration of glycopyrrolate is less than or equal to 5.0 mg/mL; and the pH of the liquid pharmaceutical composition is from 3.0 to 6.0.
Peter Lionel SPARGO, Phillip Andrew HAYWOOD, Edward James FRENCH
Filed: 26 Feb 21
Utility
Pharmaceutical Composition Comprising Ensifentrine
25 Aug 22
The present invention relates to a dry powder pharmaceutical composition suitable for administration by inhalation comprising: (i) ensifentrine particles; (ii) coarse lactose particles having a Dv50 of from 40 μm to 80 μm; and (iii) fine lactose particles having a Dv50 of from 5 μm to 10 μm, wherein: the fine lactose particles are present in an amount of from 0.1 wt % to 6.0 wt % relative to the total weight to the dry powder pharmaceutical composition.
Peter Lionel SPARGO, Edward James FRENCH
Filed: 12 Aug 20
Utility
Pharmaceutical Compositions Comprising RPL554 In HFA-134A for Administration by Inhalation
9 Dec 21
The present invention relates to a liquid pharmaceutical composition suitable for administration by inhalation comprising: (i) a suspension of particles comprising 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554); and (ii) a diluent which is 1,1,1,2-tetrafluoroethane (HFA-134a), wherein the liquid pharmaceutical composition is substantially free of surfactant.
Peter Lionel SPARGO, Phillip A. HAYWOOD
Filed: 9 Oct 19
Utility
Salt of a PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE Compound
15 Jan 20
The present invention relates to a pharmaceutically acceptable acid addition salt of: (i) 9,10-dimethoxy-2-(2,4,6-tri-methylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (RPL554); and (ii) ethane-1,2-disulfonic acid, ethanesulfonic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, hydrochloric acid, hydrobromic acid, phosphoric acid or sulfuric acid.
Peter Lionel Spargo, Edward James French, Julian Scott Northen, John Mykytiuk
Filed: 23 Sep 19
Utility
New Compound and Process
30 Oct 19
Peter Lionel Spargo
Filed: 26 Jul 17
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