229 patents
Utility
Neoadjuvant Chemotherapy Induces Breast Cancer Metastasis Through a Tmem-mediated Mechanism
18 Jan 24
Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using Tie-2 inhibitors.
John S. Condeelis, Maja Oktay
Filed: 13 Sep 23
Utility
High Resolution Intravital Imaging and Uses Thereof
4 Jan 24
Methods and apparatus are provided for high resolution intravital imaging and for chronic optical imaging of tissues such as lung.
David Entenberg, John S. Condeelis, Sonia E. Voiculescu
Filed: 21 Jun 23
Utility
Method for Predicting Patient Response to CD40-TARGETED Therapies
4 Jan 24
Methods of predicting response of a subject in need of immunosuppressant therapy to a Cluster of differentiation 40 (CD40)-targeted treatment are disclosed.
Yaron Tomer, Larissa C. Faustino, George J. Kahaly
Filed: 2 Dec 21
Utility
Stem Cell-produced Microvesicles for Treating Tendon Pathologies
28 Dec 23
Microvesicles produced by stem cells grown on a silk scaffold for enhancing stem cell self-renewal/proliferation and promoting tenogenesis in damaged tendons, and their use in tendon wound repair and tendinopathy treatment.
Hui B. Sun
Filed: 3 Mar 23
Utility
Reporter Mycobacteriophage, Assays and Methods Comprising the Reporter Mycobacteriophage
7 Dec 23
A reporter mycobacteriophage comprising a heterologous nucleic acid comprising a promoter-reporter construct encoding a promotor operably linked to a nucleotide sequence encoding a fusion protein, wherein the fusion protein comprises a luciferase protein linked to a fluorescent protein.
William R. Jacobs, Saranathan Rajagopalan, Emmanuel Asare
Filed: 1 Nov 21
Utility
Compounds useful as chaperone-mediated autophagy modulators
5 Dec 23
Ana Maria Cuervo, Evripidis Gavathiotis
Filed: 30 Aug 18
Utility
Persistance and linking of analytic products in big data environments
5 Dec 23
Persistence and linking of analytic products is provided.
Parsa Mirhaji, Jannes Aasman
Filed: 14 Jul 17
Utility
Combination Therapy Using Bax Activator Agent
23 Nov 23
A pharmaceutical combination comprising a B-cell lymphoma 2 associated X protein (BAX) activating compound an anti-apoptotic protein inhibiting compound is provided.
Evripidis Gavathiotis
Filed: 17 Sep 21
Utility
METHODS OF TREATING VIRAL INFECTIONS WITH PiRNAS OR EXTRACELLULAR VESSICLES RELEASED FROM NEURAL STEM CELLS OR NEURAL PROGENITOR CELLS
23 Nov 23
Described herein are methods of treating an individual in need of treatment or prevention of infection with a virus including administering to the individual a therapeutically effective amount of extracellular vesicles released from neural stem cells and/or neural progenitor cells, or administering to the individual a therapeutically effective amount of a composition including one or more piRNAs, wherein the piRNAs have a perfect match with a sense or antisense sequence of the genome of the virus in a primary lead sequence at positions 2-8.
Dongsheng Cai
Filed: 5 Oct 21
Utility
High-Affinity Mycobacterium Tuberculosis Capsule-Specific Human Monoclonal Antibody
16 Nov 23
Provided are high affinity Mycobacterium tuberculosis capsule-specific antibodies and fragments thereof, as well as methods of use and devices employing such antibodies and/or fragments.
Jacqueline M. Achkar, Jonathan Lai, Elise Ishida, Daniel Hofmann, Tingting Chen
Filed: 28 Apr 23
Utility
Compositions and Methods for Chimeric Antigen Receptor (Car)-modified Cell Modulation
16 Nov 23
Polypeptides, nucleic acids, and compositions thereof are provided that include a targeting moiety.
Harris GOLDSTEIN, Steven C ALMO, Scott GARFORTH, Mengyan LI
Filed: 8 Mar 21
Utility
Mitofusin activators and uses thereof
14 Nov 23
Activators of mitofusins and their uses in treatment of diseases and disorders are disclosed.
Evripidis Gavathiotis, Richard N. Kitsis, Nikolaos Biris, Emmanouil Zacharioudakis
Filed: 16 Oct 18
Utility
Agents to Prevent Tissue Damage from Clostridium Difficile Infections by Inhibition of the Gut-damaging Bacterial Toxins Tcda and TCDB
2 Nov 23
Methods for treating or preventing diseases and conditions associated with Clostridium difficile infection are provided.
Vern L. SCHRAMM, Ashleigh S. PAPARELLA, Peter Charles TYLER
Filed: 6 May 21
Utility
Method for treating neoadjuvant chemotherapy-induced metastasis
31 Oct 23
Methods of reducing chemotherapy-induced metastasis, or chemotherapy-induced cancer cell dissemination, for patients subject to chemotherapy using Tie-2 inhibitors.
John S. Condeelis, Maja Oktay
Filed: 30 May 18
Utility
Transdermal delivery formulations
17 Oct 23
A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided.
Joel M. Friedman
Filed: 25 Apr 23
Utility
Approach to sustained production and delivery of nitric oxide and s-nitrosothiols
17 Oct 23
A composition and a kit comprising a nitrite source admixed with a gelling agent for nitric oxide production.
Joel M. Friedman
Filed: 19 Sep 22
Utility
Nitric oxide-releasing device
17 Oct 23
A device for generating nitric oxide is disclosed.
Joel M. Friedman
Filed: 30 Aug 22
Utility
RNA tagging system for visualization of single mRNA molecules
10 Oct 23
An RNA tagging system for visualization of single mRNA molecules based on a MSB-MCP system, as well as methods of use.
Robert H. Singer, Evelina Tutucci, Maria Vera Ugalde
Filed: 19 Apr 18
Utility
N-cyclyl-sulfonamides Useful for Inhibiting Raf
28 Sep 23
Evripidis GAVATHIOTIS, Bogos AGIANIAN
Filed: 13 Aug 21
Utility
HSV-2-DELTA-gD VACCINES AND METHODS FOR THEIR PRODUCTION AND USE
21 Sep 23
Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, compositions and vaccines comprising such, and methods of use thereof are each provided.
William Jacobs, JR., Betsy Herold, Joseph Dardick, Kayla A. Weiss
Filed: 29 Nov 22