229 patents
Page 3 of 12
Utility
Nitric Oxide-releasing Device
2 Mar 23
A device for generating nitric oxide is disclosed.
Joel M. Friedman
Filed: 30 Aug 22
Utility
Approach to Sustained Production and Delivery of Nitric Oxide and S-nitrosothiols
2 Mar 23
A composition and a kit comprising a nitrite source admixed with a gelling agent for nitric oxide production.
Joel M. Friedman
Filed: 19 Sep 22
Utility
Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
28 Feb 23
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in subjects in need thereof.
Ana Maria Cuervo, Evripidis Gavathiotis, Qisheng Xin, Bhaskar C. Das
Filed: 4 Aug 20
Utility
Cellular Platform for Rapid and Comprehensive T-cell Immunomonitoring
16 Feb 23
Methods and systems for the efficient and systematic identification of the repertoire of T-cell epitopes.
Ronald D. Seidel, III, Rodolfo J. Chaparro, Brandan S. Hillerich, Steven C. Almo
Filed: 27 May 22
Utility
KIR3DL3 Is an Inhibitory Receptor of the Immune System and Uses Thereof
9 Feb 23
Described herein are antibodies, immunogenic fragments and compositions thereof targeting the killer-cell immunoglobulin-like receptor protein KIR3DL3, as well as methods of using the same for the treatment of human diseases including cancer.
Xingxing ZANG, Yao WEI, Xiaoxin REN, Scott MOERDLER
Filed: 1 Oct 20
Utility
Monoclonal Antibodies and Cocktails for Treatment of Ebola Infections
9 Feb 23
Described herein are compositions and methods for the prevention and treatment of ebolavirus infection.
Zachary A. Bornholdt, Larry Zeitlin, Kartik Chandran, Anna Wec, Laura Walker
Filed: 1 Jul 22
Utility
Methods of treatment by targeting VCAM1 and MAEA
24 Jan 23
Antibodies and antibody fragments that inhibit the activity of vascular cell adhesion molecule 1 (VCAM1) and/or macrophage erythroblast attacher (MAEA) are provided, along with formulations and kits comprising these antibodies and antibody fragments and the use of the disclosed compositions, formulations, and kits to treat cancers, sickle cell disease, and Polycythemia Vera.
Paul S. Frenette, Sandra Pinho, Qiaozhi Wei, Sung Kyun Lee
Filed: 27 Jan 20
Utility
Anti-crimean-congo Hemorrhagic Fever Virus Antibodies, and Methods of Their Generation and Use
5 Jan 23
Anti-CCHFV antibodies with neutralizing potency and protective efficacy against CCHFV are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.
Zachary A. Bornholdt, Akaash Mishra, Laura M. Walker, Noel T. Pauli, Daniel Maurer, Kartik Chandran, Jens Maximilian Fels, Dafna Abelson, Jason Scott McLellan, Jonathan R. Lai, Ariel Wirchnianski, Olivia Vergnolle, John M. Dye, Andrew S. Herbert
Filed: 31 May 22
Utility
HHLA2 As a Novel Inhibitor of Human Immune System and Uses Thereof
5 Jan 23
Provided are methods of treating an autoimmune disease in a subject, or of suppressing transplant rejection in a subject, or of treating a cancer in a subject, as well as compositions therefor.
Xingxing ZANG
Filed: 24 Jan 22
Utility
Small Molecule Prostagladin Transport Inhibitors
22 Dec 22
Victor L. SCHUSTER, William GREENLEE, Evripidis GAVATHIOTIS
Filed: 2 Nov 20
Utility
Inhibitors of DNMT1 as anticancer therapeutic agents
6 Dec 22
Peter Charles Tyler, Farah Lamiable-Oulaidi, Anthony David Woolhouse, Shivali Ashwin Gulab, Karl Jürgen Shaffer, Ashna Ashneen Khan, Douglas Ronald Crump, Vern L. Schramm, Quan Du
Filed: 9 Jul 19
Utility
Methods and Compositions for Rapid Functional Analysis of Gene Variants
10 Nov 22
Methods and compositions are disclosed for rapid functional analysis of gene variants based on analysis of protein-protein and protein-nucleic acid interactions.
Johnny C. LOKE, Harry OSTRER
Filed: 22 Jul 22
Utility
Compositions and Methods for Providing Cardioprotective Effects
3 Nov 22
The invention provides compositions and methods for providing a cardioprotective effect in a subject.
Lorraine J. GUDAS, Xiao-Han Tang, Roberto Levi, Jessica Gambardella, Gaetano Santulli
Filed: 30 Jun 22
Utility
Biotin Synthases for Efficient Production of Biotin
3 Nov 22
A recombinant microorganism includes a transgene encoding a polypeptide of a Type II biotin synthase, wherein a holo-protein of the Type II biotin synthase comprises per polypeptide chain a first [4Fe—4S] cluster (radical SAM (RS) cluster) coordinated to a CxxxCxxC motif in the polypeptide chain and a second [4Fe—4S] cluster.
Steven C. ALMO, Tyler GROVE
Filed: 4 Sep 20
Utility
Transdermal delivery formulations
1 Nov 22
A transdermal formulation for the delivery of a nitric oxide booster or nitric oxide precursor to a subject is provided.
Joel M. Friedman
Filed: 30 Dec 21
Utility
Methods and Compositions for Diagnosing and Treating, Germline Mismatch Repair Deficiencies, Lynch Syndrome and Assessing Germline Risks of Cancer
27 Oct 22
Heritable pathogenic variants in the mismatch repair (MMR) pathway, also known as Lynch Syndrome (LS), can lead to the development of colon cancer and other cancers.
Harry OSTRER, Johnny C. LOKE, Ishraq ALIM
Filed: 19 May 22
Utility
FGF receptor ligands for treating diabetes and obesity
25 Oct 22
Methods for treating diabetes or obesity are provided comprising administering to the subject an amount of an agent that binds a central nervous system FGF receptor homodimer.
Streamson Chua, Jr.
Filed: 18 Sep 19
Utility
Glycosylated Diphyllin As a Broad-spectrum Antiviral Agent Against Zika Virus and COVID-19
13 Oct 22
Felipe DIAZ-GRIFFERO
Filed: 28 Aug 20
Utility
Methods for Assessing the Risk of Developing Active Tuberculosis
13 Oct 22
This disclosure describes markers that are associated with active tuberculosis (TB) and demonstrates that the disclosed markers can be used as a biomarker for determining whether a subject has or is at risk of having active TB and for the early detection of HIV-associated TB.
Jacqueline M. Achkar, Eustache Paramithiotis
Filed: 2 Oct 20
Utility
Stem-loop compositions and methods for inhibiting factor D
11 Oct 22
The application discloses methods and compositions for the inhibition of the alternative complement pathway.
Carl Erickson, Christopher P. Rusconi, Kevin G. McLure, Matthew Levy, Arijit Bhowmick
Filed: 15 Aug 19