228 patents
Page 12 of 12
Utility
Ion exchange purification of mRNA
16 Mar 20
The current landscape for preparative chromatographic RNA purification uses reversed phase HPLC, but this technique presents many issues with process scale up and ion exchange for preparative purification has only been used for short RNAs.
William Joseph Issa, Joseph Louis Barberio, John Grant Aunins, Noubar B. Afeyan
Filed: 13 Mar 14
Utility
POLYNUCLEOTIDES ENCODING METHYLMALONYL-CoA MUTASE
11 Mar 20
The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof.
Paolo Martini, Vladimir Presnyak, Kerry Benenato, Stephen Hoge, Iain McFadyen, Ellalahewage Sathyajith Kumarasinghe
Filed: 17 Jul 19
Utility
In vivo production of proteins
9 Mar 20
The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
Antonin De Fougerolles, Justin Guild
Filed: 13 Jun 19
Utility
Stabilized Formulations of Lipid Nanoparticles
4 Mar 20
The disclosure features novel lipids and compositions involving the same.
Mike SMITH, Orn ALMARSSON, Luis BRITO
Filed: 13 Jun 17
Utility
Varicella Zoster Virus (VZV) Vaccine
4 Mar 20
Aspects of the disclosure relate to nucleic acid vaccines.
Giuseppe Ciaramella
Filed: 14 Mar 18
Utility
Respiratory Virus Nucleic Acid Vaccines
4 Mar 20
Provided herein, in some embodiments, are vaccines (and vaccination methods) that include a ribonucleic acid (RNA) polynucleotide encoding a human metapneumovims (hMPV) F protein and a RNA polynucleotide encoding a human parainfluenza virus 3 (hPrV3) F protein.
Giuseppe Ciaramella, Sunny Himansu
Filed: 7 Dec 17
Utility
Rna Affinity Purification
4 Mar 20
Provided herein, in some embodiments, are methods of purifying a nucleic acid preparation.
Edward J. Miracco
Filed: 12 Dec 17
Utility
Modified polynucleotides for the production of secreted proteins
2 Mar 20
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Antonin De Fougerolles, Justin Guild
Filed: 11 Jun 19