228 patents
Page 8 of 12
Utility
Immunomodulatory Therapeutic Mrna Compositions Encoding Activating Oncogene Mutation Peptides
6 May 21
The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator.
Eric Yi-Chun HUANG, Sze-Wah TSE, Jared IACOVELLI, Kristine MCKINNEY, Nicholas VALIANTE
Filed: 18 Nov 20
Utility
Polynucleotides encoding citrin for the treatment of Citrullinemia type 2
4 May 21
The invention relates to mRNA therapy for the treatment of Citrullinemia Type 2 (“CTLN2”). mRNAs for use in the invention, when administered in vivo, encode human Citrin, isoforms thereof, functional fragments thereof, and fusion proteins comprising Citrin. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of Citrin expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of biomarkers associated with deficient Citrin activity in subjects, namely ammonia and/or triglycerides.
Paolo Martini, Stephen Hoge, Kerry Benenato, Vladimir Presnyak, Iain McFadyen, Ellalahewage Sathyajith Kumarasinghe, Jingsong Cao, Lin Tung Guey, Staci Sabnis
Filed: 18 May 17
Utility
Modified Polynucleotides for the Production of Proteins Associated with Human Disease
22 Apr 21
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Stephane BANCEL, Tirtha CHAKRABORTY, Antonin DE FOUGEROLLES, Sayda M. ELBASHIR, Matthias JOHN, Atanu ROY, Susan WHORISKEY, Kristy M. WOOD, Paul HATALA, Jason P. SCHRUM, Kenechi EJEBE, Jeff Lynn ELLSWORTH, Justin GUILD
Filed: 28 Oct 19
Utility
MRNA combination therapy for the treatment of cancer
13 Apr 21
The present disclosure relates to the use of nucleic acid (e.g., mRNA) combination therapies for the treatment of cancer.
Joshua P. Frederick, Susannah Hewitt, Ailin Bai, Stephen G. Hoge, Vladimir Presnyak, Iain McFadyen, Kerry Benenato, Ellalahewage Sathyajith Kumarasinghe
Filed: 28 Jun 19
Utility
Branched Tail Lipid Compounds and Compositions for Intracellular Delivery of Therapeutic Agents
25 Mar 21
The disclosure features novel lipids and compositions involving the same.
Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY, Ellalahewage S. KUMARASINGHE
Filed: 18 Sep 20
Utility
In Vivo Production of Proteins
18 Mar 21
The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
Antonin DE FOUGEROLLES, Justin GUILD
Filed: 6 Mar 20
Utility
Multimeric Polynucleotides and Uses Thereof
4 Mar 21
Aspects of the disclosure relate to multimeric molecules and methods of producing the same.
Brian R. FRITZ
Filed: 18 Jan 19
Utility
Betacoronavirus mRNA vaccine
2 Mar 21
The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
Giuseppe Ciaramella, Sunny Himansu
Filed: 21 May 20
Utility
Influenza vaccine
23 Feb 21
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more influenza antigens, such as hemagglutinin antigens.
Giuseppe Ciaramella
Filed: 10 Nov 17
Utility
Terminally Modified RNA
23 Feb 21
The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules via optimization of their terminal architecture.
Tirtha Chakraborty, Stephane Bancel, Stephen G. Hoge, Atanu Roy, Antonin De Fougerolles, Noubar B. Afeyan
Filed: 5 Oct 18
Utility
RSV Rna Vaccines
18 Feb 21
The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.
Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Andrew J. Bett, Pedro Cejas, Lan Zhang, Christine Shaw
Filed: 28 Jan 19
Utility
Polynucleotides Encoding Phenylalanine Hydroxylase for the Treatment of Phenylketonuria
11 Feb 21
This disclosure relates to mRNA therapy for the treatment of hyperphenylalaninemias such as phenylketonuria (PKU). mRNAs for use in the invention, when administered in vivo, encode human phenylalanine hydroxylase (PAH), functional fragments thereof (e.g., those comprising the catalytic domain or the catalytic domain and the tetramerization domains), and fusion proteins comprising PAH. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to effect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of PAH expression and/or activity in subjects. mRNA therapies of the invention further decrease abnormal accumulation of phenylalanine associated with deficient PAH activity in subjects.
Raj Rajendran, Patrick Finn, Paolo G.V. Martini, Ding An, Athanasios Dousis, Kanchana Ravichandran
Filed: 21 Nov 18
Utility
Combinations of Mrnas Encoding Immune Modulating Polypeptides and Uses Thereof
11 Feb 21
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
Joshua FREDERICK, Ailin BAI, Vladimir PRESNYAK, Stephen G. HOGE, Kerry BENENATO, Iain MCFADYEN, Ellalahewage Sathyajith KUMARASINGHE, Susannah HEWITT
Filed: 15 Oct 20
Utility
Delivery and formulation of engineered nucleic acids
26 Jan 21
Provided are formulations, compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression.
Antonin de Fougerolles, Sayda M. Elbashir
Filed: 21 Mar 18
Utility
Immunomodulatory therapeutic MRNA compositions encoding activating oncogene mutation peptides
4 Jan 21
The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator.
Eric Yi-Chun Huang, Sze-Wah Tse, Jared Iacovelli, Kristine McKinney, Nicholas Valiante
Filed: 18 Feb 19
Utility
Combination HPIV3/HMPV Rna Vaccines
30 Dec 20
The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
Giuseppe Ciaramella, Sunny Himansu
Filed: 9 Jun 20
Utility
Modified Rna Encoding Vegf-a Polypeptides, Formulations, and Uses Relating Thereto
30 Dec 20
The disclosure relates to modified RNA molecules encoding VEGF-A polypeptides and formulations comprising the modified RNA.
Leif Karlsson PARINDER, Regina Desirée FRITSCHE DANIELSON, Kenny Mikael HANSSON, Li Ming GAN, Jonathan CLARKE, Ann-Charlotte Eva EGNELL, Kenneth Randall CHIEN
Filed: 5 Jun 17
Utility
Removal of DNA fragments in mRNA production process
7 Dec 20
The present invention describes methods of removing DNA from an RNA transcript during the mRNA production process.
William Joseph Issa, Yuxun Wang, Stephane Bancel
Filed: 29 Jul 18
Utility
Compounds and compositions for intracellular delivery of therapeutic agents
7 Dec 20
The disclosure features novel lipids and compositions involving the same.
Kerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
Filed: 11 Apr 19
Utility
Polynucleotides Encoding INTERLEUKIN-12 (IL12) and Uses Thereof
2 Dec 20
The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12.
Joshua FREDERICK, Susannah HEWITT, Ailin BAI, Stephen HOGE, Vladimir PRESNYAK, Iain MCFADYEN, Kerry BENENATO, Ellalahewage Sathyajith KUMARASINGHE
Filed: 6 Apr 20