153 patents
Page 5 of 8
Utility
Coronavirus Rna Vaccines
29 Jul 21
The disclosure relates to coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.
Mihir Metkar, Vladimir Presnyak, Guillaume Stewart-Jones
Filed: 21 Aug 20
Utility
Removal of Dna Fragments In Mrna Production Process
29 Jul 21
The present invention describes methods of removing DNA from an RNA transcript during the mRNA production process.
William Joseph ISSA, Yuxun WANG, Stephane BANCEL
Filed: 7 Dec 20
Utility
Nucleic Acid Vaccines
22 Jul 21
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
Giuseppe Ciaramella, Axel Bouchon, Eric Yi-Chun Huang
Filed: 17 Mar 21
Utility
Variational Autoencoder for Biological Sequence Generation
15 Jul 21
Techniques for manufacturing a variant of a target protein.
Andrew Giessel, Athanasios Dousis, Iain McFadyen
Filed: 8 Jan 21
Utility
Messenger Ribonucleic Acids for the Production of Intracellular Binding Polypeptides and Methods of Use Thereof
8 Jul 21
The invention features isolated mRNAs encoding at least one intracellular binding domain, including mRNAs comprising one or more modified nucleobase and preferably lacking an encoded scaffold polypeptide, and methods of using the same, for example, for inducing apoptosis and/or treating cancer (e.g., liver cancer or colorectal cancer).
Eric Yi-Chun HUANG, Joshua P. FREDERICK, Kristine MCKINNEY, Christina HENDERSON, Kahlin CHEUNG-ONG, Joseph BOLEN, Stephen Michael KELSEY, Michael MORIN, Sushma GURUMURTHY, Kerry BENENATO, Stephen HOGE, Iain MCFADYEN, Vladimir PRESNYAK
Filed: 20 Jan 17
Utility
Compounds and Compositions for Intracellular Delivery of Agents
1 Jul 21
The disclosure features amino lipids and compositions involving the same.
Kerry E. BENENATO, William BUTCHER
Filed: 14 Jun 18
Utility
Broad Spectrum Influenza Virus Vaccine
24 Jun 21
The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine.
Giuseppe Ciaramella, Eric Yi-Chun Huang, Kerim Babaoglu, Jessica Anne Flynn, Lan Zhang, David Nickle
Filed: 15 Mar 18
Utility
Influenza Vaccine
10 Jun 21
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more influenza antigens, such as hemagglutinin antigens.
Giuseppe Ciaramella
Filed: 18 Dec 20
Utility
Methods for HPLC Analysis
3 Jun 21
Aspects of the disclosure relate to liquid chromatography (e.g., HPLC) methods which enable high resolution separations of polynucleotides having hydrophobic portions (e.g., polyadenylated nucleic acids, such as mRNA) based upon the hydrophobic character of the molecules (e.g., polyA tail length).
William Issa, Meredith Packer
Filed: 17 Aug 18
Utility
Messenger Rna Comprising Functional Rna Elements
3 Jun 21
The present disclosure provides messenger RNAs (mRNAs) having chemical and/or structural modifications, including RNA elements and/or modified nucleotides, in particular C-rich or CG-rich elements, which provide a desired translational regulatory activity to the mRNA.
David REID, Caroline KÖHRER, Ruchi JAIN, Melissa J. MOORE, Scott DONOVAN, Aaron LARSEN, Vladimir PRESNYAK
Filed: 11 Apr 19
Utility
Assembly and Error Reduction of Synthetic Genes from Oligonucleotides
3 Jun 21
The present invention relates to a rapid, high-fidelity process to support synthesis of genes for in vitro transcription of modified messenger RNA.
Marcus R. DUVALL, Kevin SMITH, Robin HUANG, Andrew GIESSEL
Filed: 19 Mar 19
Utility
Compounds and Compositions for Intracellular Delivery of Agents
3 Jun 21
The disclosure features amino lipids and compositions involving the same.
Kerry E. BENENATO, William BUTCHER
Filed: 12 Aug 20
Utility
Compounds and Compositions for Intracellular Delivery of Therapeutic Agents
27 May 21
The disclosure features novel lipids and compositions involving the same.
Kerry E. BENENATO, Ellalahewage Sathyajith KUMARASINGHE, Mark CORNEBISE
Filed: 23 Sep 20
Utility
Rna Formulations
20 May 21
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins.
Stephen Hoge, Joseph Schariter, Charles Bowerman, Michael H. Smith, Yan Xia
Filed: 15 Jun 18
Utility
Immunomodulatory Therapeutic Mrna Compositions Encoding Activating Oncogene Mutation Peptides
6 May 21
The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator.
Eric Yi-Chun HUANG, Sze-Wah TSE, Jared IACOVELLI, Kristine MCKINNEY, Nicholas VALIANTE
Filed: 18 Nov 20
Utility
Modified Polynucleotides for the Production of Proteins Associated with Human Disease
22 Apr 21
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Stephane BANCEL, Tirtha CHAKRABORTY, Antonin DE FOUGEROLLES, Sayda M. ELBASHIR, Matthias JOHN, Atanu ROY, Susan WHORISKEY, Kristy M. WOOD, Paul HATALA, Jason P. SCHRUM, Kenechi EJEBE, Jeff Lynn ELLSWORTH, Justin GUILD
Filed: 28 Oct 19
Utility
Branched Tail Lipid Compounds and Compositions for Intracellular Delivery of Therapeutic Agents
25 Mar 21
The disclosure features novel lipids and compositions involving the same.
Kerry E. BENENATO, Mark CORNEBISE, Edward HENNESSY, Ellalahewage S. KUMARASINGHE
Filed: 18 Sep 20
Utility
In Vivo Production of Proteins
18 Mar 21
The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
Antonin DE FOUGEROLLES, Justin GUILD
Filed: 6 Mar 20
Utility
Multimeric Polynucleotides and Uses Thereof
4 Mar 21
Aspects of the disclosure relate to multimeric molecules and methods of producing the same.
Brian R. FRITZ
Filed: 18 Jan 19
Utility
RSV Rna Vaccines
18 Feb 21
The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.
Giuseppe Ciaramella, Kapil Bahl, Amy Espeseth, Andrew J. Bett, Pedro Cejas, Lan Zhang, Christine Shaw
Filed: 28 Jan 19