153 patents
Page 8 of 8
Utility
Polynucleotides Encoding Methylmalonyl-coa Mutase
29 Apr 20
The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof.
Paolo G. V. Martini, Vladimir Presnyak
Filed: 12 Jun 18
Utility
Herpes Simplex Virus Vaccine
29 Apr 20
The disclosure relates to herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
Giuseppe Ciaramella, Shinu John, Andrew J. Bett, Danilo R. Casimiro, Dai Wang, Lan Zhang
Filed: 14 Mar 18
Utility
Lipid Nanoparticle Formulation
29 Apr 20
The disclosure features novel lipids and compositions involving the same.
Siddharth PATEL, Emily ROBINSON, Anna BROWN, Orn ALMARSSON, Kerry E. BENENATO, Staci SABNIS, Gaurav SAHAY, Ashwani Kumar NARAYANA
Filed: 14 Mar 18
Utility
Compounds and Compositions for Intracellular Delivery of Therapeutic Agents
22 Apr 20
The disclosure features novel lipids and compositions involving the same.
Kerry E. BENENATO, Mark CORNEBISE
Filed: 28 Aug 19
Utility
Combinations of Mrnas Encoding Immune Modulating Polypeptides and Uses Thereof
15 Apr 20
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
Joshua P. FREDERICK, Ailin BAI, Vladimir PRESNYAK, Stephen G. HOGE, Kerry BENENATO, Iain MCFADYEN, Ellalahewage Sathyajith KUMARASINGHE, Susannah HEWITT
Filed: 15 Aug 19
Utility
Reduction or Elimination of Immune Responses to Non-intravenous, E.g., Subcutaneously Administered Therapeutic Proteins
8 Apr 20
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering nucleic acids in vivo.
Luis Brito, Gilles Besin
Filed: 4 Apr 18
Utility
Polynucleotides Encoding Tethered INTERLEUKIN-12 (IL12) Polypeptides and Uses Thereof
1 Apr 20
The present disclosure relates to polynucleotides encoding tethered interleukin-12 (IL-12) polypeptides comprising an IL-12 polypeptide and a membrane domain.
Ankita MISHRA, Joshua FREDERICK, Sushma GURUMURTHY
Filed: 17 May 18
Utility
Polynucleotides Encoding Porphobilinogen Deaminase for the Treatment of Acute Intermittent Porphyria
18 Mar 20
The invention relates to mRNA therapy for the treatment of Acute Intermittent Porphyria (AIP). mRNAs for use in the invention, when administered in vivo, encode human porphobilinogen deaminase (PBGD), isoforms thereof, functional fragments thereof, and fusion proteins comprising PBGD. mRNAs of the invention are preferably encapsulated in lipid nanoparticles (LNPs) to affect efficient delivery to cells and/or tissues in subjects, when administered thereto. mRNA therapies of the invention increase and/or restore deficient levels of PBGD expression and/or activity in subjects. mRNA therapies of the invention further decrease levels of toxic metabolites associated with deficient PBGD activity in subjects, namely porphobilinogen and aminolevulinate (PBG and ALA).
Paolo Martini, Stephen Hoge, Kerry Benenato, Vladimir Presnyak, Lei Jiang, Iain McFadyen, Ellalahewage Sathyajith Kumarasinghe, Antonio Fontanellas Roma, Pedro Berraondo Lopez, Matias Antonio Avila Zaragoza, Lin Tung Guey, Staci Sabnis
Filed: 17 May 17
Utility
POLYNUCLEOTIDES ENCODING METHYLMALONYL-CoA MUTASE
11 Mar 20
The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof.
Paolo Martini, Vladimir Presnyak, Kerry Benenato, Stephen Hoge, Iain McFadyen, Ellalahewage Sathyajith Kumarasinghe
Filed: 17 Jul 19
Utility
Stabilized Formulations of Lipid Nanoparticles
4 Mar 20
The disclosure features novel lipids and compositions involving the same.
Mike SMITH, Orn ALMARSSON, Luis BRITO
Filed: 13 Jun 17
Utility
Varicella Zoster Virus (VZV) Vaccine
4 Mar 20
Aspects of the disclosure relate to nucleic acid vaccines.
Giuseppe Ciaramella
Filed: 14 Mar 18
Utility
Respiratory Virus Nucleic Acid Vaccines
4 Mar 20
Provided herein, in some embodiments, are vaccines (and vaccination methods) that include a ribonucleic acid (RNA) polynucleotide encoding a human metapneumovims (hMPV) F protein and a RNA polynucleotide encoding a human parainfluenza virus 3 (hPrV3) F protein.
Giuseppe Ciaramella, Sunny Himansu
Filed: 7 Dec 17
Utility
Rna Affinity Purification
4 Mar 20
Provided herein, in some embodiments, are methods of purifying a nucleic acid preparation.
Edward J. Miracco
Filed: 12 Dec 17