463 patents
Page 3 of 24
Utility
Cleaning device for blood vessel sealing apparatus
3 Oct 23
A cleaner device is adapted to clean a blood vessel sealer device.
Gagandeep Singh
Filed: 9 Jul 21
Utility
Compositions and Uses of SARS-COV-2 Targeted Chimeric Antigen Receptor Modified NK Cells
28 Sep 23
Chimeric antigen receptors (CAR) targeted to SARS-CoV-2 Spike protein and NK cells expressing such CAR are described.
Jianhua Yu, Michael A. Caligiuri
Filed: 11 Aug 21
Utility
Personalized Treatment Using Metabolic Fingerprint Based Simulation
28 Sep 23
Providing a personalized treatment by using a metabolic fingerprint is described.
Fouad KANDEEL, Christopher ORR
Filed: 4 Jun 21
Utility
T-cell lymphoma treatments
26 Sep 23
Described herein are methods for treating T-cell lymphoma in a subject in need thereof, comprising administering to the subject in need thereof, an ETP compound.
David Horne, Sangkil Nam
Filed: 15 Jun 18
Utility
Recombinant lectin and uses thereof
26 Sep 23
Disclosed herein are a recombinant Streptomyces S27S5 hemagglutinin (SHA), and homologues thereof, and a fusion protein of a fluorescent protein (such as GFP and mCherry1) and SHA or a homologue thereof, which specifically bind to carbohydrates, including oligomeric sugars that terminate in L-rhamnose or D-galactose.
Markus Kalkum, Yoko Fujita-Yamaguchi, Karine Bagramyan, Teresa B. Hong, Sarah Shuck
Filed: 4 Aug 21
Utility
Short hairpin RNA compositions, methods of making and applications thereof
26 Sep 23
Provided herein are novel synthetic short hairpin RNA (shRNA) molecules and compositions and kits comprising such molecules, as well as methods of making and using these molecules, compositions, and kits.
Guihua Sun
Filed: 16 Oct 20
Utility
Splice inhibiting oligonucleotides
26 Sep 23
Provided herein are, inter alia, oligonucleotides, kits, and methods useful for increasing lentiviral titers.
John C. Burnett, Elizabeth Epps, John J. Rossi
Filed: 28 Jul 21
Utility
Genetically Stable Recombinant Modified Vaccinia Ankara (Rmva) Vaccines and Methods of Preparation Thereof
21 Sep 23
A vaccine comprising an immunologically effective amount of recombinant modified vaccinia Ankara (rMVA) virus which is genetically stable after serial passage and produced by a) constructing a transfer plasmid vector comprising a modified H5 (mH5) promoter operably linked to a DNA sequence encoding a heterologous foreign protein antigen, wherein the expression of said DNA sequence is under the control of the mH5 promoter; b) generating rMVA virus by transfecting one or more plasmid vectors obtained from step a) into wild type MVA virus; c) identifying rMVA virus expressing one or more heterologous foreign protein antigens using one or more selection methods for serial passage; d) conducting serial passage; e) expanding an rMVA virus strain identified by step d); and f) purifying the rMVA viruses from step e) to form the vaccine.
Don J. DIAMOND, Zhongde WANG
Filed: 28 Nov 22
Utility
TKI permeability enhancers
19 Sep 23
Provided herein are, inter alia, methods useful for delivering nucleic acids and kinase inhibitors to a cell.
Cy Aaron Stein, Daniela Castanotto, David Horne
Filed: 17 Nov 15
Utility
Treatments for Cancers Having Kras Mutations
14 Sep 23
Provided herein are, inter alia, methods for treating cancers having KRAS mutations using ITGB4/PXN pathway inhibitors, Wnt/β-catenin pathway inhibitors, KRAS pathway inhibitors, and combinations thereof; and pharmaceutical compositions comprising the ITGB4/PXN pathway inhibitors, Wnt/β-catenin pathway inhibitors, KRAS pathway inhibitors, and combinations thereof.
Prakash Kulkarni, Ravi Salgia, Atish Mohanty
Filed: 5 Aug 21
Utility
Cancer detection and ablation system and method
12 Sep 23
Systems and methods are configured to detect and/or ablate cancerous tissue, such as during surgery.
Yuman Fong, Michael Storrie-Lombardi, Veronica Jones, Daniel Schmolze, Lily L. Lai, Ragini Kothari
Filed: 30 Apr 19
Utility
Haploidentical Mixed Chimerism for Treating Autoimmune Diseases
7 Sep 23
Disclosed are methods of treating or preventing autoimmune diseases by inducing haploidentical mixed chimerism and condition regimen for by inducing haploidentical mixed chimerism.
Defu ZENG
Filed: 17 Feb 23
Utility
CS1 targeted chimeric antigen receptor-modified T cells for treatment of AL amyloidosis
5 Sep 23
Methods for treating AL amyloidosis using chimeric antigen receptors targeting CS1 are described.
Xiuli Wang, Stephen J. Forman
Filed: 20 Mar 18
Utility
Peptide Design and GALECTIN-3 Inhibitors
31 Aug 23
Provided herein are, inter alia, methods and systems for the in silico design of peptide inhibitors for proteins comprising disordered domains; Galectin-3 inhibitors; and methods for treating and detecting diseases that overexpress or inappropriately express Galectin-3.
Nora Heisterkamp, Supriyo Bhattacharya
Filed: 2 Aug 21
Utility
Cell penetrating antibodies
22 Aug 23
Provided herein are cell penetrating conjugates.
Andreas Herrmann, Hua Yu
Filed: 15 Jan 16
Utility
CS1 targeted chimeric antigen receptor-modified T cells
22 Aug 23
Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.
Xiuli Wang, Stephen J. Forman
Filed: 13 Aug 20
Utility
Combination Therapy for Treating Cancer
17 Aug 23
Provided herein, inter alia, are radionuclide-labeled antibodies, immunocytokines, and methods for treating cancer using combination therapy with the radionuclide-labeled antibodies and the immunocytokines.
John E. Shively, Maciej Kujawski, Megan Minnix, Paul Yazaki
Filed: 22 Dec 22
Utility
Breast Cancer Biomarkers and Methods of Use
17 Aug 23
The disclosure provides, inter alia, breast cancer biomarkers, methods of detecting exhausted CD8+ T cells in breast cancer patients, methods of detecting CD26+CD4+ T cells in breast cancer patients, methods of treating breast cancer patients, and methods of identifying risk outcomes for breast cancer patients.
Peter P. Lee, Colt Egelston, Weihua Guo, Jiayi Tan
Filed: 6 Feb 23
Utility
Methods, compositions, and kits for detection of aspergillosis
15 Aug 23
Provided herein are methods for detecting an Aspergillus protease in a sample, diagnosing a subject with aspergillosis caused by an Aspergillus infection based on the presence of an Aspergillus protease in a sample, and methods of aspergillosis treatment that incorporate these diagnostic methods.
Markus Kalkum, Karine Bagramyan, Diana Diaz-Arevalo, James I. Ito, Sanjeet Dadwal
Filed: 11 May 20
Utility
Antibodies for Coronavirus and Uses Thereof
10 Aug 23
Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein receptor binding domain.
Pamela J. Bjorkman, Alexander A. Cohen, Chengcheng Fan, John C. Williams, Miso Park
Filed: 1 Dec 22