463 patents
Page 5 of 24
Utility
Compositions and Methods Comprising Clostridium Butyricum for the Treatment of Cancer
18 May 23
Provided herein, inter alia, are methods and compositions for the treatment of cancer.
Peter P. Lee, Sumanta Kumar Pal
Filed: 20 Apr 21
Utility
Oncolytic Virus Compositions Including IL-15 Complex and Methods for the Treatment of Cancer
11 May 23
Provided herein, inter alia, are compositions and methods including recombinant oncolytic viruses expressing human IL-15 and human IL-15Rα-sushi domain for the treatment of cancer and immune disorders.
Jianhua Yu, Michael A. Caligiuri
Filed: 22 Jan 21
Utility
Multivalent Chemokine Receptor Binding Complexes
11 May 23
Provided herein are, inter alia, multi-specific ligand binding complexes capable of binding tumor-associated antigens and effector cell activating ligands.
John C. WILLIAMS, Miso PARK
Filed: 18 Mar 21
Utility
Conditional-siRNAS and uses thereof in treating acute myeloid leukemia
9 May 23
Disclosed herein are conditional siRNAs activatable by CBFβ-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML).
Guido Marcucci, Ya-Huei Kuo, Si-ping Han, Lisa Scherer, William A. Goddard, III, John Rossi
Filed: 10 Feb 20
Utility
Methods for intracellular delivery and enhanced gene targeting
9 May 23
Disclosed herein are methods and compositions for enhancing gene targeting.
Daniela Castanotto, Cy Stein, Xiaowei Zhang
Filed: 15 Nov 17
Utility
Method for determining lymphoma type and providing treatment
9 May 23
In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements.
Louis M. Staudt, Christian Steidl, Anja Mottok, George W. Wright, David William Scott, Lisa M. Rimsza, Andreas Rosenwald, Randy Gascoyne, Timothy Greiner, Dennis Weisenburger, Erlend B. Smeland, Jan Delabie, Elias Campo Guerri, German Ott, Rita Braziel, Elaine S. Jaffe, Kai Fu, Wing C. Chan, Joo Song, James R. Cook
Filed: 13 Dec 19
Utility
Expression System for Expressing Herpesvirus Glycoprotein Complexes
4 May 23
An expression system for expressing a herpesvirus glycoprotein complex including a vector inserted with two or more nucleic acid sequences that encode two or more subunits of a herpesvirus glycoprotein complex linked by one or more linking sequences such that the subunits are co-expressed simultaneously and self-processed to assemble into a glycoprotein complex.
Felix WUSSOW, Don J. DIAMOND
Filed: 9 Jun 22
Utility
Neural Stem Cell-mediated Cancer Treatment
4 May 23
Provided are methods and compositions for treating cancer with a combination of neural stem cells (NSCs) and an oncolytic virus or a combination of oncolytic virotherapy and immune modulation.
Alexandra Jacqueline ANNALA, Karen ABOODY, Jennifer COVELLO, Rachael MOONEY
Filed: 11 Jul 22
Utility
Nasal Swab
4 May 23
Methods of manufacture, devices, and systems are described for a nasal swab.
Yuman Fong, Colin Andrew Cook, Thomas J Gernon, Stanley Ralph Hamilton, Marylin Roque, Kevin Alexander Proudfoot, Sophie Yu, Natalie Krieger, Vivian Ho Lam, Kaitlyn Paulsen, Kaushal Gokli, Leila Wiberg, Tristan Aniken Huang, Vadim Peter Mathys
Filed: 28 Oct 22
Utility
Wnt/cbp/catenin Signaling Pathway Inhibitors and Uses Thereof
4 May 23
Disclosed herein are, inter alia, compounds modulating activity and methods of use thereof for treating CBP/β-catenin mediated disorders.
Michael KAHN, David HORNE
Filed: 11 Mar 21
Utility
IGF2BP2 Inhibitors and Uses Thereof
27 Apr 23
Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same.
Jianjun Chen, Hengyou Weng, Huilin Huang, David Horne, Yuelong Ma, Hongzhi Li, Xiaolan Deng
Filed: 27 Jan 21
Utility
CONDITIONAL-siRNAS AND USES THEREOF IN TREATING CARDIAC HYPERTROPHY
6 Apr 23
Disclosed herein are conditional siRNAs activatable by pro-hypertrophic RNA sequences and use thereof for treating conditions such as cardiac hypertrophy.
Saumya DAS, Ane Miren SALVADOR GARICANO, Si-ping HAN, Lisa SCHERER, Julia DEROGATIS, Robin HU, Sahil SAGAR, William A. GODDARD, III, John ROSSI
Filed: 10 Aug 18
Utility
Composition and method for activating latent human immunodeficiency virus (HIV)
4 Apr 23
Provided are compositions and methods for activating latent Human Immunodeficiency Virus (HIV).
Kevin V. Morris, Marc S. Weinberg, Tristan Scott, Daniel Lazar
Filed: 22 Oct 18
Utility
Poxvirus-based Vectors Produced by Natural or Synthetic Dna and Uses Thereof
30 Mar 23
Disclosed are methods of producing poxvirus-based vectors or recombinant poxvirus-based vectors from naturally derived, chemically synthesized DNA fragments, or a combination of naturally derived and chemically synthesized DNA fragments.
Don J. DIAMOND, Felix WUSSOW
Filed: 2 Feb 21
Utility
Anti-cancer phosphorothioate-coupled peptide conjugates and methods of using the same
21 Mar 23
Provided herein are, inter alia, nucleic acid-peptide conjugates including a non-cell penetrating protein (e.g., an Hdm2 targeting peptide) attached at its C-terminus to a phosphorothioate nucleic acid.
Andreas Herrmann, Hua Yu, Yanwen Fu
Filed: 13 Jul 18
Utility
Multi-modal image-guided radiation system
21 Mar 23
Systems and methods relate to multi-modal imaging of tissue combined with highly focused radiation interventions.
Susanta K. Hui, Gultekin Gulsen, Farouk Nouizi
Filed: 28 May 20
Utility
ANTI-IL1RAP Antibodies
16 Mar 23
Provided herein are, inter alia, antibodies capable of binding Interleukin-1 receptor accessory protein (IL1RAP).
Weixu MENG, Guido MARCUCCI
Filed: 28 Jun 22
Utility
Design and Development of Masked Therapeutic Antibodies to Limit Off-target Effects
16 Mar 23
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof.
John C. Williams, Cindy Zer, Kendra N. Avery, Ulrich Rodeck, Joshua M. Donaldson, Csaba Kari
Filed: 25 Apr 22
Utility
P53-targeting vaccines and pd-1 pathway inhibitors and methods of use thereof
14 Mar 23
The disclosure provides, inter alia, methods and materials involved in treating cancer using a p53 vaccine in combination with a PD-1 pathway inhibitor.
Don J. Diamond
Filed: 8 Dec 17
Utility
Methods for detection of botulinum neurotoxin
14 Mar 23
Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin.
Markus Kalkum, Karine Bagramyan
Filed: 14 Sep 20