463 patents
Page 9 of 24
Utility
Neural stem cell-mediated cancer treatment
16 Aug 22
Provided are methods and compositions for treating cancer with a combination of neural stem cells (NSCs) and an oncolytic virus or a combination of oncolytic virotherapy and immune modulation.
Alexandra Jaqueline Annala, Karen Aboody, Jennifer Covello, Rachael Mooney
Filed: 29 Apr 19
Utility
Substrates for high-density cell growth and metabolite exchange
16 Aug 22
A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides.
Yu-Chong Tai, Yang Liu, Colin A. Cook, Yuman Fong, Nanhai G. Chen
Filed: 10 Aug 18
Utility
CCR4 Targeted Chimeric Antigen Receptor Modified T Cells for Treatment of CCR4 Positive Malignancies
11 Aug 22
Chimeric antigen receptors for use in treating lymphoma-associated C-C chemokine receptor type 4 (CCR4) and other cancers expressing CCR4 are described.
Lihua Elizabeth Budde, Marissa M. Del Real, Stephen Forman
Filed: 22 May 20
Utility
PDL1 Positive NK Cell Cancer Treatment
11 Aug 22
Provided herein are methods of treating cancer in a subject including detecting an amount of PD-L1(+) natural killer (NK) cells in a biological sample from the subject and treating the subject with an anti cancer therapy.
Jianhua Yu, Michael A. Caligiuri, Wenjuan Dong
Filed: 24 Jun 20
Utility
Twist signaling inhibitor compositions and methods of using the same
9 Aug 22
The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
Carlotta A. Glackin, John J. Rossi, Jeffrey I. Zink, Fuyuhiko Tamanoi, Cai M. Roberts, James Finlay
Filed: 22 Nov 19
Utility
Anticancer Combinations
4 Aug 22
Provided herein, inter alia, are compositions and kits comprising a bacterial cell and a tumor penetrating agent.
Don J. Diamond, Edwin Manuel
Filed: 17 Sep 21
Utility
Epstein-Barr virus antibodies and uses thereof
2 Aug 22
Disclosed herein are antibodies or immunogenic fragments thereof that specifically bind to Epstein-Barr virus (EBV) glycoprotein 350 (gp350) or 220 or one or more epitopes of EBV gp350 and neutralize EBV infection.
Javier Gordon Ogembo, Lorraine Zvichapera Mutsvunguma, Alison Evelynn Ondrus
Filed: 27 Apr 18
Utility
Methods and compositions for treating endometrial cancer
19 Jul 22
Provided herein are, inter alia, methods and compositions for treating cancer in a subject in need thereof comprising a therapeutically effective amount of a stilbenoid compound and a progestin.
Thanh Dellinger
Filed: 14 Sep 18
Utility
Expression system for expressing herpesvirus glycoprotein complexes
19 Jul 22
An expression system for expressing a herpesvirus glycoprotein complex including a vector inserted with two or more nucleic acid sequences that encode two or more subunits of a herpesvirus glycoprotein complex linked by one or more linking sequences such that the subunits are co-expressed simultaneously and self-processed to assemble into a glycoprotein complex.
Felix Wussow, Don J. Diamond
Filed: 13 Jul 18
Utility
MVA-gH/gL-PC vaccine derived antibodies neutralizing human cytomegalovirus infectivity and methods thereof
12 Jul 22
Vaccine-derived neutralizing antibodies (NAbs) for CMV infections and small peptides which define precise recognition elements of the antigens by the NAbs.
Don J. Diamond, Flavia Chiuppesi, Felix Wussow
Filed: 11 Nov 19
Utility
Compositions and Methods for Targeting Tumor-associated Extracellular Matrix Components to Improve Drug Delivery
23 Jun 22
Provided herein are compositions and methods to treat tumors that include attenuated facultative anaerobic bacterium.
Edwin Ramos Manuel, Don J. Diamond
Filed: 15 May 20
Utility
Loop-mediated Isothermal Amplification Devices and Systems for Detecting Genetic Material
23 Jun 22
Provided are methods, devices, and systems for a loop-mediated isothermal amplification (LAMP) reactions for detecting the presence of genetic material.
Markus Kalkum, Daniel Roeth, Isaac Bishara, Miro Rusnak, Sanjeet Dadwal
Filed: 22 Dec 21
Utility
Energy-enhanced, hand-held vascular sealer
14 Jun 22
A hand tool has a pivot connection pivotally attaching a first arm to a second arm, with the pivot connection fixed relative to the first arm and movable to first and second positions relative to the second arm.
Gagandeep Singh
Filed: 1 Nov 18
Utility
Chimeric Antigen Receptors Containing a Chlorotoxin Domain
9 Jun 22
Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain that includes chlorotoxin or a related toxin, or a variant of chlorotoxin or a related toxin, that binds to human glioma or other human tumor cells, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
Michael Barish, Christine E. Brown, Stephen J. Forman, Dongrui Wang
Filed: 5 Nov 21
Utility
PCNA inhibitors
31 May 22
Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
Linda H. Malkas, David Horne, Robert J. Hickey, Long Gu
Filed: 1 Dec 20
Utility
Multivalent Kaposi Sarcoma-associated Herpesvirus-like Particles and Uses Thereof
12 May 22
Disclosed are vaccine compositions comprising a single KSHV-LP comprising two or more KSHV glycoproteins and/rl or one or more T cell antigens and methods of preventing or treating KSHV infections using the vaccine compositions.
Javier Gordon OGEMBO, Lorraine Zvichapera MUTSVUNGUMA, David H. MULAMA, Murali MUNIRAJU
Filed: 21 Feb 20
Utility
Methods for Manufacturing T Cells Expressing of Chimeric Antigen Receptors and Other Receptors
12 May 22
A method for manufacturing T cell populations enriched for cells expressing CD27 and useful in T cell therapy is described.
Christine E. Brown, Dongrui Wang, Stephen J. Forman
Filed: 30 Mar 20
Utility
CTLA-4 Aptamer Conjugates
12 May 22
Provided herein are, inter alia, nucleic acid compounds useful for targeting CTLA-4-expressing cells and modulating cell activity of the CTLA-4-expressing cells.
Hua YU, Andreas HERRMANN, Marcin Tomasz KORTYLEWSKI
Filed: 25 Oct 21
Utility
TXNIP-TRX complex inhibitors and methods of using the same
10 May 22
Disclosed herein, inter alia, are compounds and methods for inhibiting the thioredoxin-thioredoxin-interacting-protein (TXNIP-TRX) complex.
Rama Natarajan, Feng Miao, Nagarajan Vaidehi, Supriyo Bhattacharya, Adrien Beau Larsen
Filed: 13 Sep 19
Utility
BAFF-R/CD19 Targeted Chimeric Antigen Receptor-modified T Cells and Use Thereof
28 Apr 22
Chimeric antigen receptors targeting both BAFF-R and CD19 are described as are methods for their use.
Hong Qin, Xiuli Wang, Larry Wonshin Kwak, Stephen J. Forman
Filed: 20 Feb 20