463 patents
Page 13 of 24
Utility
Cell Penetrating Conjugates and Methods of Use Thereof
28 Oct 21
Provided herein are cell penetrating conjugates.
Andreas HERRMANN, Hua YU, Piotr Marek SWIDERSKI, John Ernest SHIVELY, Lin LI
Filed: 24 Feb 21
Utility
Cleaning Device for Blood Vessel Sealing Apparatus
28 Oct 21
A cleaner device is adapted to clean a blood vessel sealer device.
Gagandeep Singh
Filed: 9 Jul 21
Utility
Truncated epiderimal growth factor receptor (EGFRt) for transduced T cell selection
26 Oct 21
A non-immunogenic selection epitope may be generated by removing certain amino acid sequences of the protein.
Michael C. Jensen
Filed: 15 Oct 18
Utility
Chemically Encoded Spatially Addressed Library Screening Platforms
21 Oct 21
Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.
Jacob BERLIN, Gregory COPELAND, Kathleen ELISON, Hurik MURADYAN
Filed: 22 Apr 21
Utility
Methods and Compositions Comprising Tyrosine Kinase Inhibitor and Triptolide for the Treatment of Cancer
14 Oct 21
Provided herein, inter alia, are methods, compositions and kits for treating cancer in a subject.
Binghui Shen, Li Zheng, Karen Reckamp, Ravi Salgia
Filed: 8 Apr 21
Utility
Anticancer combinations
12 Oct 21
Provided herein, inter alia, are compositions and kits comprising a bacterial cell and a tumor penetrating agent.
Don J. Diamond, Edwin Manuel
Filed: 22 Dec 15
Utility
Methods, Compositions, and Kits for Improving Pancreatic Beta Cell Viability and Treating Diseases or Conditions Related to Beta Cell Destruction
7 Oct 21
The present disclosure provides novel methods for increasing β-cell viability in islets by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to the islets.
Sanjay AWASTHI, Sushma YADAV, Ismail AL ABDULLAH, Fouad KANDEEL, Brian MCFADDEN, Indu NAIR, Sharad S. SINGHAL
Filed: 19 Apr 21
Utility
DOC2B As a Biomarker for Type 1 and Type 2 Diabetes
7 Oct 21
Disclosed is the use of DOC2B as an early stage biomarker for diagnosing type 1 diabetes (T1D), pre-T1D, type 2 diabetes (T2D), pre-T2D or for assessing the risk of T1D, pre-T1D, T2D, or pre-T2D.
Debbie C. THURMOND
Filed: 15 Apr 21
Utility
TAG72 Targeted Chimeric Antigen Receptor Modified T Cells for Treatment of TAG72-POSITIVE Tumors
7 Oct 21
Chimeric antigen receptors targeted to TAG72 and the use thereof to treat ovarian cancer and other cancers are described
Saul J. Priceman, John P. Murad, Stephen J. Forman, Jack Shively, Paul Yazaki, David Colcher, Anna Kozlowska, Hee Jun Lee
Filed: 1 Aug 19
Utility
Compounds of Chemically Modified Oligonucleotides and Methods of Use Thereof
7 Oct 21
The present disclosure relates to isolated compounds including a nucleic acid sequence capable of hybridizing to an RNA sequence 10 to 270 nucleobases downstream of the transcription start site of a mammalian microRNA-379 transcript; methods of treating a condition of a subject (e.g., diabetes, obesity, or complications thereof) with the compounds; and methods of inhibiting expression of a mammalian microRNA-379 megacluster with the compounds.
Mitsuo KATO, Rama NATARAJAN
Filed: 16 Aug 19
Utility
Cationic Compounds for Delivery of Nucleic Acids
7 Oct 21
Provided herein, inter alia, are compositions, including compounds comprising a polynucleotide covalently linked to a cyanine moiety.
John BURNETT, Anh PHAM
Filed: 30 Aug 19
Utility
BAFF-R antibodies and uses thereof
5 Oct 21
Provided herein are BAFF-R antibodies as well as compositions and methods of making and using the same.
Hong Qin, Larry W. Kwak, Jingxing Li, Kexin Huang
Filed: 6 Jun 17
Utility
HUMAN iPSC-DERIVED BRAIN ORGANOIDS AND USES THEREOF
30 Sep 21
Disclosed are methods of producing human iPSC-derived brain organoids and uses thereof to detect and develop treatment for HCMV-induced brain deformation in developing fetus.
Yanhong SHI, Guoqiang SUN, Xianwei CHEN
Filed: 22 Mar 21
Utility
Compositions and Methods of Alleviating Resistance to Chemotherapy
16 Sep 21
Disclosed herein are methods and compositions for alleviating resistance to chemotherapy in a subject using one or more therapeutic agents that perturb the interaction between integrin β4 (ITGB4) and paxillin (PXN), e.g., by inhibiting the expression of ITGB4, PXN, or both.
Ravi SALGIA, Atish MOHANTY
Filed: 23 Sep 20
Utility
Implantable Device for Retaining Live Cells and Providing Nutrients Thereto
16 Sep 21
An oxygen transporter device configured to transport O2 from an ambient air location into or toward a subcutaneous site.
Hirotake Komatsu, Colin Andrew Cook, Yu-Chong Tai, Kuang-Ming Shang
Filed: 12 Mar 21
Utility
Use of endogenous viral vaccine in chimeric antigen receptor T cell therapy
14 Sep 21
Provided herein are, inter alia, methods and compositions including T cells expressing (i) a recombinant CAR protein which includes a peptide binding site and is capable of specifically binding cancer-specific antigens and (ii) a T cell receptor specific for a viral antigen (e.g., a CMV pp65 protein).
John C. Williams, Christine Brown, Don J. Diamond
Filed: 19 Oct 17
Utility
Conditioning regimens and methods for inducing mixed chimerism
14 Sep 21
Disclosed herein are conditioning regimens and methods for inducing MHC- or HLA-mismatched mixed chimerism by conditioning a recipient with radiation-free, low-doses of cyclophosphamide (CY), pentostatin (PT), and anti-thymocyte globulin (ATG) prior to transplantation of donor bone marrow cells.
Defu Zeng
Filed: 10 Nov 16
Utility
Pyridopyrazine compounds and uses thereof
14 Sep 21
Disclosed herein, inter alia, are pyridopyrazines and methods of using the same.
Sangkil Nam, David Horne, Ravi Salgia, Alexios-Leandros Skaltsounis, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos
Filed: 21 Jun 18
Utility
Novel Short Hairpin Rna Compositions, Methods of Making and Applications Thereof
9 Sep 21
Provided herein are novel synthetic short hairpin RNA (shRNA) molecules and compositions and kits comprising such molecules, as well as methods of making and using these molecules, compositions, and kits.
Guihua SUN
Filed: 16 Oct 20
Utility
Modification of Small Rnas for Therapeutic Uses
2 Sep 21
Provided are methods for improving stability of small therapeutic RNAs by adding one or more non-templated nucleotides such as cytidines and uridines to the 3′ end of the small therapeutic RNAs.
John J. ROSSI, Minsun SONG
Filed: 27 Jun 19