463 patents
Page 16 of 24
Utility
Method of Inactivating a Glucocorticoid Receptor Gene In an Isolated Cell
8 Apr 21
Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR.
Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
Filed: 18 Dec 20
Utility
Cell penetrating conjugates and methods of use thereof
6 Apr 21
Provided herein are cell penetrating conjugates.
Andreas Herrmann, Hua Yu, Piotr Marek Swiderski, John Ernest Shively, Lin Li
Filed: 29 Feb 16
Utility
Adoptive transfer of CD8+ T cell clones derived from central memory cells
6 Apr 21
The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount.
Stanley R. Riddell, Susanna Carolina Berger, Michael C. Jensen
Filed: 17 Jul 19
Utility
Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy
30 Mar 21
In one embodiment, a single modality cancer immunotherapy regimen that includes a therapeutic composition is provided.
Don J. Diamond, Edwin Manuel
Filed: 25 Nov 19
Utility
Neural Stem Cell Delivery of Therapeutic Agents
18 Mar 21
The disclosure provides, inter alia, neural stem cells comprising exogenous nucleotides, vesicles comprising exogenous nucleotides, and methods for treating diseases and disorders, such as cancer, neurodegenerative diseases, inflammatory diseases, and viral diseases, using the neural stem cells, vesicles, and pharmaceutical compositions comprising them.
Marcin Tomasz Kortylewski, Karen Aboody, Alexandra Jacqueline Annala, Mohamed Hammad
Filed: 21 Aug 20
Utility
Adeno-associated Virus Vector Variants for High Efficiency Genome Editing and Methods Thereof
18 Mar 21
Adeno-associated virus (AAV) Clade F vectors or AAV vector variants (relative to AAV9) for precise editing of the genome of a cell and methods and kits thereof are provided.
Saswati CHATTERJEE, Laura Jane SMITH, Kamehameha WONG
Filed: 24 Apr 20
Utility
Pcna Inhibitors
18 Mar 21
Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
Linda H. Malkas, David Horne, Robert J. Hickey, Long Gu
Filed: 1 Dec 20
Utility
Peptide inhibitors of twist
16 Mar 21
The disclosure provides, inter alia, compositions comprising TWIST peptide inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
Carlotta A. Glackin
Filed: 8 Apr 20
Utility
Multi-specific Ligand Binders
4 Mar 21
Provided herein are, inter alia, novel peptide compositions having multi-specific binding capabilities useful for therapeutic and diagnostic purposes.
John C. WILLIAMS, Jeremy KING
Filed: 7 Jan 19
Utility
Genetically Modified Recombinant Vaccinia Ankara (Rmva) Vaccines of Improved Stability and Methods of Preparation Thereof
4 Mar 21
A vaccine composition comprising an immunologically effective amount of recombinant modified vaccinia Ankara (rMVA) virus comprising IE1, IE2 and pp65 or antigenic fragments thereof, which is genetically stable after at least 10 passages.
Felix WUSSOW, Don J. DIAMOND, Heidi CONTRERAS
Filed: 11 Nov 20
Utility
Meditope-enabled T Cells
4 Mar 21
Provided herein are compositions which exhibit novel therapeutic capabilities and allow to reduce the off-target effect of therapeutic antibodies.
John C. WILLIAMS, Christine BROWN, Kurt JENKINS, Yi-Chiu KUO, Cheng-Fu KUO
Filed: 31 Dec 18
Utility
Mva Vectors for Expressing Multiple Cytomegalovirus (CMV) Antigens and Use Thereof
4 Mar 21
Disclosed is an expression system for co-expressing multiple human cytomegalovirus (HCMV) antigens to stimulate potent humoral and cellular immune responses against HCMV infection.
Felix WUSSOW, Don J. DIAMOND
Filed: 11 Nov 20
Utility
Tropic Cell Based Virotherapy for the Treatment of Cancer
4 Mar 21
In some embodiments, methods of killing tumor cells are provided.
Karen S. ABOODY, Alexander J. ANNALA, David CURIEL, Maciej LESNIAK
Filed: 13 Jul 20
Utility
Lighting and optics surgical system
2 Mar 21
Lighting and optical devices, systems, and methods are configured for use in laparoscopic surgical procedures.
Yuman Fong
Filed: 30 Apr 19
Utility
5-BROMO-INDIRUBINS
25 Feb 21
Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML.
Sangkil Nam, David Horne, Jun Xie
Filed: 6 Jul 20
Utility
Neural Stem Cell Compositions Including Chimeric Poxviruses for Cancer Treatment
25 Feb 21
Provided are methods and compositions for treating cancer with a combination of neural stem cells (NSCs) and a replication-competent oncolytic virus such as conditionally replication-competent chimeric orthopoxvirus (CF33).
Alexandra J. ANNALA, Karen S. ABOODY, Yuman FONG, Nanhai G. CHEN, Mohamed HAMMAD, Rachael MOONEY, Jennifer COVELLO
Filed: 30 Apr 19
Utility
Chimeric Antigen Receptors and Methods for Reducing Toxicity
18 Feb 21
Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ζ signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.
Xiuli Wang, Stephen J. Forman, Lawrence Stern, Christine E. Brown, Joseph Cohen
Filed: 25 Jan 19
Utility
Compounds and Compositions Including Phosphorothioated Oligodeoxynucleotide, and Methods of Use Thereof
11 Feb 21
The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.
Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Dayson Friaca Moreira
Filed: 24 Jul 20
Utility
PCNA inhibitors
9 Feb 21
Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
Linda H. Malkas, David Horne, Robert J. Hickey, Long Gu
Filed: 13 Dec 19
Utility
Hand-held Grasping Device
4 Feb 21
A hand tool has a pivot connection pivotally attaching a first arm to a second arm, with the pivot connection fixed relative to the first arm and movable to first and second positions relative to the second arm.
Gagandeep Singh
Filed: 25 Sep 20