463 patents
Page 19 of 24
Utility
Targeting Glioblastoma Stem Cells Through the TLX-TET3 Axis
30 Sep 20
Methods and compositions capable of modulating activity of TLX (NR2E1), a nuclear receptor essential for neural stem cell self-renewal are provided.
Yanhong Shi, Qi Cui, Su Yang
Filed: 18 Mar 20
Utility
Compounds of chemically modified oligonucleotides and methods of use thereof
28 Sep 20
The present disclosure relates to isolated compounds including a nucleic acid sequence capable of hybridizing to an RNA sequence 10 to 270 nucleobases downstream of the transcription start site of a mammalian microRNA-379 transcript; method of treating diabetic nephropathy in a subject with the compounds; and method of inhibiting expression of a mammalian microRNA-379 megacluster with the compounds.
Rama Natarajan, Mitsuo Kato
Filed: 24 May 16
Utility
Aptamer Compositions and the Use Thereof
23 Sep 20
Provided are aptamer compositions and their use for treating cancer.
John J. Rossi, Sorah Yoon, Nagy Habib
Filed: 30 Mar 17
Utility
Deterministic Mechanoporation for Cell Engineering
16 Sep 20
Intracellular delivery of a genetic construct to immune cells including: obtaining a deterministic mechanoporation (DMP) platform that includes a substrate having a surface and a plurality of capture sites, each said capture site having a boundary shape at the surface adapted and configured to support thereon a cell, and each said capture site having a bottom and including a sub-micron-scale projection extending from the bottom toward the surface of the substrate, wherein said projection is adapted and configured to penetrate a cell membrane and/or wall of the cell, and wherein the substrate has a plurality of aspiration vias situated at the bottom of the capture sites; introducing the cells to the surface in a liquid media; capturing the cells within the capture sites by applying a first hydrodynamic force; applying a second hydrodynamic force on the captured cell and locally rupturing the membrane and/or wall of the cell with the projection, introducing the genetic construct into the cells, and releasing the porated cells from the capture sites.
Masaru P. Rao, Harish G. Dixit, Hideaki Tsutsui, Morgan L. Dundon, Pranee I. Pairs, Stephen J. Forman, Christine E. Brown, Renate Starr, Christopher B. Ballas
Filed: 9 Mar 20
Utility
Farnesoid X Receptor Antagonists
16 Sep 20
Provided herein are Farnesoid X receptor (FXR) antagonists having the structure of formula (I), and pharmaceutical compositions comprising the compound of formula (I) and a pharmaceutically acceptable excipient.
Barry Forman, Donna Yu
Filed: 29 Mar 20
Utility
Substrates for detection of botulinum neurotoxin
14 Sep 20
Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin.
Markus Kalkum, Karine Bagramyan
Filed: 5 Feb 17
Utility
Methods of Using ANTI-MIR126 Compounds
9 Sep 20
Provided herein are, inter alia, methods of treating red blood cell disorders and cancer using anti-miR126 compounds.
Guido Marcucci, Bin Zhang, Ya-Huei Kuo, Marcin Tomasz Kortylewski
Filed: 4 Mar 20
Utility
Prevention and Treatment of GVHD and Autoimmune Diseases
9 Sep 20
Disclosed herein are methods of preventing and treating GVHD and autoimmune diseases.
Defu ZENG, Arthur RIGGS
Filed: 3 Oct 18
Utility
5-BROMO-INDIRUBINS
9 Sep 20
Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
Richard Jove, Sangkil Nam, David Horne, Jun Xie, Alexios Leandros Skaltsounis, Marina Kritsanida, Nicolas Gaboriaud-Kolar
Filed: 12 Feb 20
Utility
Compositions of and methods of treatment with zwitterionic polysaccharide
7 Sep 20
The present disclosure includes compositions of a zwitterionic polysaccharide (e.g., B. fragilis capsular polysaccharide A (PSA)) (including active fragments thereof) and methods of treating viral infection and viral infection associated inflammation with compositions of a zwitterionic polysaccharide (e.g., B. fragilis capsular polysaccharide A (PSA)) (including active fragments thereof).
Edouard Cantin, Sarkis K. Mazmanian, Chandran Ramakrishna
Filed: 9 Jun 16
Utility
Chemically encoded spatially addressed library screening platforms
7 Sep 20
Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.
Jacob Berlin, Gregory Copeland, Kathleen Elison, Hurik Muradyan
Filed: 28 Aug 19
Utility
Multivalent Epstein-barr Virus-like Particles and Uses Thereof
2 Sep 20
Disclosed are vaccine compositions comprising a VLP comprising two or more EBV envelope glycoproteins and one or more T cell antigens and methods of preventing or treating EBV infections using the vaccine compositions.
Javier Gordon OGEMBO, Lorraine Zvichapera MUTSVUNGUMA
Filed: 15 Sep 18
Utility
Chimeric Antigen Receptor Compositions
2 Sep 20
Provided herein are compositions, which exhibit diagnostic capabilities and allow to rapidly add functionality to adoptive immunotherapy.
John C. Williams, Christine Brown
Filed: 5 Feb 20
Utility
Synthesis of Etp Derivatives
2 Sep 20
Provided herein, inter alia, is the synthesis of ETP derivatives.
David Horne, Jun Xie
Filed: 21 May 18
Utility
Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
31 Aug 20
The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.
Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Dayson Friaca Moreira
Filed: 29 Jun 16
Utility
NIR-conjugated tumor-specific antibodies and uses thereof
31 Aug 20
Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors.
Paul Yazaki, Jack Shively, Michael Bouvet, Jonathan Delong, Yuman Fong
Filed: 24 Jan 18
Utility
Chemically encoded spatially addressed library screening platforms
31 Aug 20
Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.
Jacob Berlin, Gregory Copeland, Kathleen Elison, Hurik Muradyan
Filed: 23 Feb 16
Utility
Methods, Compositions, and Kits for Detection of Aspergillosis
26 Aug 20
Provided herein are methods for detecting an Aspergillus protease in a sample, diagnosing a subject with aspergillosis caused by an Aspergillus infection based on the presence of an Aspergillus protease in a sample, and methods of aspergillosis treatment that incorporate these diagnostic methods.
Markus KALKUM, Karine BAGRAMYAN, Diana DIAZ-AREVALO, James I. ITO, Sanjeet DADWAL
Filed: 10 May 20
Utility
CD123-Specific Chimeric Antigen Receptor Redirected T Cells and Methods of Their Use
12 Aug 20
A family of chimeric antigen receptors (CARs) containing a CD123 specific scFv was developed to target different epitopes on CD123.
Stephen J. Forman, Armen Mardiros, Christine E. Brown, Uma Maheswara Rao Jonnalagadda
Filed: 26 Apr 20
Utility
Composition and Method for Activating Latent Human Immunodeficiency Virus (Hiv)
12 Aug 20
Provided are compositions and methods for activating latent Human Immunodeficiency Virus (HIV).
Kevin V. MORRIS, Marc S. WEINBERG, Tristan SCOTT, Daniel LAZAR
Filed: 21 Oct 18