463 patents
Page 20 of 24
Utility
SYNTHETIC CONJUGATE OF CpG DNA AND T-HELP/CTL PEPTIDE
5 Aug 20
Highly effective vaccine compositions are constructed according to the methods of this invention.
Don J. DIAMOND
Filed: 5 Feb 20
Utility
Indirubin Derivatives, and Uses Thereof
5 Aug 20
Indirubin is the major active anti-tumor component of a traditional Chinese herbal medicine used for treatment of chronic myelogenous leukemia (CML).
Sangkil NAM, Richard JOVE, Leandros SKALTSOUNIS
Filed: 6 Oct 19
Utility
ANTI-IL1RAP Antibodies
5 Aug 20
Provided herein are, inter alia, antibodies capable of binding Interleukin-1 receptor accessory protein (IL1RAP).
Weixu MENG, Guido MARCUCCI
Filed: 31 Jul 18
Utility
Peptide Inhibitors of Twist
22 Jul 20
The disclosure provides, inter alia, compositions comprising TWIST peptide inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
Carlotta A. Glackin
Filed: 7 Apr 20
Utility
ANTI-CD33 Antibody-guided Imaging and Treatment of Acute Myeloid Leukemia
22 Jul 20
Disclosed is a non-invasive PET-CT imaging method for detecting acute myeloid leukemia (AML) or extramedullary disease (EMD) in a subject using a radioactive isotope-labeled anti-CD33 antibody.
Susanta Kumar HUI, Paul J. YAZAKI, Srideshikan Sargur MADABUSHI
Filed: 20 Nov 19
Utility
Methods of Treatment Using Decitabine and a CD123-TARGETED Therapy
15 Jul 20
The present disclosure relates generally to methods treatment of hematological cancers, such as blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), or Myelodysplastic Syndrome (MDS), comprising a combination of decitabine and a CD123-targeted therapy.
Pam Cohen, Sadik Kassim, Ekta Patel, Elizabeth Budde, Stephen J. Forman
Filed: 26 Nov 19
Utility
Compositions and Methods of Modulating Macrophage Activity
15 Jul 20
Disclosed herein, inter alia, are compositions and methods of modulating macrophage activity.
Jacob Berlin, Tom Haber, Yvonne Cornejo
Filed: 28 Jun 18
Utility
Tropic cell based virotherapy for the treatment of cancer
13 Jul 20
In some embodiments, methods of killing tumor cells are provided.
Karen S. Aboody, Alexander J. Annala, David Curiel, Maciej Lesniak
Filed: 20 Mar 19
Utility
CTLA-4 aptamer siRNA species
13 Jul 20
Provided herein are, inter alia, nucleic acid compounds useful for targeting CTLA-4-expressing cells and modulating cell activity of the CTLA-4-expressing cells.
Hua Yu, Andreas Herrmann, Marcin Tomasz Kortylewski
Filed: 20 Jan 15
Utility
Pcna Inhibitors
8 Jul 20
Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
Linda H. Malkas, David Horne, Robert J. Hickey, Long Gu
Filed: 12 Dec 19
Utility
Splice Inhibiting Oligonucleotides
8 Jul 20
MicroRNAs embedded within an intron, which are called ‘mirtrons,’ can be used as a platform for expressing one or more shRNA or miRNA mimics in a lentiviral vector.
John C. Burnett, Elizabeth Epps, John J. Rossi
Filed: 20 Sep 18
Utility
Oncolytic Virus Expressing a Car T Cell Target and Uses Thereof
8 Jul 20
An oncolytic poxvirus encoding a truncated human CD19 is used in conjunction with a chimeric antigen receptor to treat solid tumors.
Yuman Fong, Saul J. Priceman, Stephen J. Forman, Nanhai Chen, Anthony K. Park
Filed: 9 Aug 18
Utility
5-bromo-indirubins
6 Jul 20
Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML.
Sangkil Nam, David Horne, Jun Xie
Filed: 8 Feb 18
Utility
Bile acid receptor modulators and methods of use thereof
6 Jul 20
Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of bile acid receptor activity.
Donna Yu, Barry Forman
Filed: 17 Oct 17
Utility
Baff-r Bispecific T-cell Engager Antibody
24 Jun 20
Provided herein are recombinant proteins (e.g., a bispecific antibody) capable of binding BAFF-R.
Hong Qin, Larry W. Kwak
Filed: 18 Dec 19
Utility
CTLA4-binding protein peptide-linker masks
22 Jun 20
Provided herein are recombinant CTLA-4 binding proteins, which are, inter alia, useful for the treatment of cancer.
John Williams, Ulrich Rodeck
Filed: 12 Jan 16
Utility
Methods of Treating Advanced Prostate Cancer
17 Jun 20
Provided herein are methods for treating metastatic prostate cancer using anti-androgen compounds and radionuclide-labeled androgens.
Zijie Sun, David Horne, Junfeng Li, John E. Shively, Jun Xie
Filed: 10 Feb 20
Utility
Baff-r Antibodies and Uses Thereof
17 Jun 20
Provided herein are BAFF-R antibodies as well as compositions and methods of making and using the same.
Hong QIN, Larry W. KWAK, Jingxing LI, Kexin HUANG
Filed: 5 Jun 17
Utility
CS1 Targeted Chimeric Antigen Receptor-modified T Cells for Treatment of Al Amyloidosis
17 Jun 20
Methods for treating AL amyloidosis using chimeric antigen receptors targeting CS1 are described.
Xiuli Wang, Stephen J. Forman
Filed: 19 Mar 18
Utility
Nucleic Acid-functionalized Nanoparticles
17 Jun 20
Provided herein are functionalized nanoparticle compositions and methods of using the same.
Jacob Berlin, Pamela Tiet
Filed: 11 Feb 20