463 patents
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Utility
Compositions and Methods for the Treatment of Hypercholesterolemia
5 Feb 20
Provided herein are, inter alia, compositions and methods for the treatment of hypercholesterolemia.
Kevin V. MORRIS, Roslyn RAY
Filed: 1 Feb 18
Utility
Neural Stem Cell-mediated Cancer Treatment
5 Feb 20
Provided are methods and compositions for treating cancer with a combination of neural stem cells (NSCs) and an oncolytic virus or a combination of oncolytic virotherapy and immune modulation.
Alexander J. Annala, Karen Aboody, Jennifer Covello, Rachael Mooney
Filed: 28 Apr 19
Utility
CHIMERIC ANTIGEN RECEPTORS (CARs) HAVING MUTATIONS IN THE FC SPACER REGION AND METHODS FOR THEIR USE
5 Feb 20
Chimeric antigen receptors that include an antigen recognition domain; a spacer domain derived from a modified immunoglobulin Fc region having one or more mutations in its CH2 region resulting in impaired binding to an FcR; and an intracellular signaling domain.
Stephen J. Forman, Christine E. Brown, Uma Maheswara Rao Jonnalagadda, Armen Mardiros
Filed: 13 Dec 18
Utility
PCNA inhibitors
3 Feb 20
Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
Linda H. Malkas, David Horne, Robert J. Hickey, Long Gu
Filed: 15 Sep 16
Utility
Anti-cancer RNA aptamers
3 Feb 20
Provided herein, inter alia, are compounds capable of binding HSP70 (e.g. mHSP70) on a cell and internalizing into said cell.
John J. Rossi, Sorah Yoon, Nagy Habib
Filed: 30 Mar 16
Utility
Methods and Compositions for the Treatment of Cancer or Other Diseases
29 Jan 20
The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases.
Hua Yu, Marcin Kortylewski, Richard Jove, Piotr Marek Swiderski, John J. Rossi
Filed: 5 Mar 19
Utility
Oligonucleotides Containing 2'-DEOXY-2'FLUORO-BETA-D-ARABINOSE Nucleic Acid (2'-FANA) for Treatment and Diagnosis of Retroviral Diseases
29 Jan 20
The disclosure relates to synthetic oligonucleotides that bind at least a portion of a dimerization initiation site (DIS) of a retrovirus genomic ribonucleic acid (RNA) molecule.
John J. Rossi, Masad J. Damha, Veenu Aishwarya, Mayumi Takahashi, Haitang Li
Filed: 22 Sep 17
Utility
Rotational scanning endoscope
20 Jan 20
A rotational scanning endoscope for rotationally scanning to capture a circumferential image
Chao Han, Lily L Lai, Jiangtao Huangfu, Changhuei Yang
Filed: 21 Dec 14
Utility
Multivalent oligonucleotide assemblies
20 Jan 20
Provided herein, inter alia, are double stranded oligonucleotide molecules and methods of making the molecules.
Piotr Swiderski
Filed: 12 Jul 16
Utility
Twist signaling inhibitor compositions and methods of using the same
30 Dec 19
The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
Carlotta A. Glackin, John Rossi, Jeffrey I. Zink, Fuyuhiko Tamanoi, Cai M. Roberts, James Finlay
Filed: 9 Feb 17
Utility
Methods, compositions, and kits for detection of bacterial proteases
30 Dec 19
Provided herein are novel fluorogenic and bioluminescent bacterial protease substrates that contain at least one bacterial protease cleavage site.
Markus Kalkum, Ismail Al-Abdullah
Filed: 12 Feb 18
Utility
Chemically Encoded Spatially Addressed Library Screening Platforms
25 Dec 19
Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.
Jacob BERLIN, Gregory Copeland, Kathleen Elison, Hurik Muradyan
Filed: 28 Aug 19
Utility
Chimeric Antigen Receptors Containing a Chlorotoxin Domain
25 Dec 19
Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain that includes chlorotoxin or a related toxin, or a variant of chlorotoxin or a related toxin, that binds to human glioma or other human tumor cells, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
Michael Barish, Christine E. Brown, Stephen J. Forman, Dongrui Wang
Filed: 12 Oct 16
Utility
Encapsulated Diagnostics and Therapeutics In Nanoparticles - Conjugated to Tropic Cells and Methods for Their Use
25 Dec 19
A therapeutic or diagnostic delivery vehicle is provided.
Karen ABOODY, Alexander ANNALA, Rachael MOONEY, Jacob BERLIN, Yiming WENG
Filed: 6 Aug 19
Utility
PHOSPHOROTHIOATE-CONJUGATED miRNAs AND METHODS OF USING THE SAME
4 Dec 19
Andreas Herrmann, Hua Yu
Filed: 2 Jun 19
Utility
Treatment of Cancer
27 Nov 19
Provided herein, inter alia, are methods of treating cancer in a subject, by administering COH29 ((N-(4-(3,4-dihydroxyphenyl)-5-phenylthia-zol-2-yl)-3,4-dihydroxybenzamide)).
Joseph Chao, David Horne, Paul Frankel
Filed: 5 Feb 18
Utility
Adoptive Transfer of CD8+ T Cell Clones Derived from Central Memory Cells
27 Nov 19
The present invention provides a method of carrying out adoptive immunotherapy in a primate subject in need thereof by administering the subject a cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount.
Stanley R. Riddell, Susanna Carolina Berger, Michael C. Jensen
Filed: 16 Jul 19
Utility
MVA-gh/gL-PC vaccine derived antibodies neutralizing human cytomegalovirus infectivity and methods thereof
25 Nov 19
Disclosed are vaccine-derived neutralizing antibodies (NAbs) for CMV infections and small peptides which define precise recognition elements of the antigens by the NAbs.
Don J. Diamond, Flavia Chiuppesi, Felix Wussow
Filed: 8 Mar 18
Utility
Margin Extension Device and Method
20 Nov 19
A margin extension device and method are disclosed herein.
Gagandeep Singh, Jonathan Kessler
Filed: 4 Aug 19
Utility
Single chain antibody domains for detection of anti-botulinum neurotoxin domains and methods of their use
18 Nov 19
Provided herein, inter alia, are single chain antibody binding domains (VHHs) for use in conjunction with the Assay with a Large Immuno-sorbent Surface Area (ALISSA).
Markus Kalkum, Karine Bagramyan, Paul Yazaki
Filed: 28 Feb 16