463 patents
Page 14 of 24
Utility
Treatment of Cancer
2 Sep 21
Provided herein, inter alia, are methods of treating cancer in a subject, by administering COH29 ((N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide)).
Joseph Chao, David Horne, Paul Frankel
Filed: 12 Nov 20
Utility
Oligonucleotide-based Proteolysis Targeting Chimera
2 Sep 21
Disclosed herein, inter alia, are oligonucleotide-based proteolysis targeting chimeras and methods of use thereof.
Marcin Kortylewski, Piotr Marek Swiderski, Steven Rosen
Filed: 17 Jun 19
Utility
Splice inhibiting oligonucleotides
31 Aug 21
MicroRNAs embedded within an intron, which are called ‘mirtrons,’ can be used as a platform for expressing one or more shRNA or miRNA mimics in a lentiviral vector.
John C. Burnett, Elizabeth Epps, John J. Rossi
Filed: 21 Sep 18
Utility
Surgical Gauze
26 Aug 21
A surgical material, such as gauze, includes a feature that increases the magnetic permeability of the surgical material.
Gagandeep Singh
Filed: 25 Feb 21
Utility
Anti-Baff Receptor Antibodies and Uses Thereof
26 Aug 21
Anti-BAFF-R antibodies and antigen-binding fragments thereof with potentially high stability and low immunogenicity are described.
Jianbing Zhang, Hong Qin, Larry W. Kwak
Filed: 19 Feb 21
Utility
Methods for Detection of Botulinum Neurotoxin
19 Aug 21
Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin.
Markus KALKUM, Karine BAGRAMYAN
Filed: 14 Sep 20
Utility
Administration of Engineered T Cells for Treatment of Cancers in the Central Nervous System
12 Aug 21
An improved method of treating cancers with engineered T cells is described.
Behnam Badie, Christine E. Brown, Stephen J. Forman, Saul J. Priceman
Filed: 18 Sep 20
Utility
Cleaning device for blood vessel sealing apparatus
3 Aug 21
A cleaner device is adapted to clean a blood vessel sealer device.
Gagandeep Singh
Filed: 22 Jan 19
Utility
Programmable Conditional Sirnas and Uses Thereof
29 Jul 21
Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents.
Si-ping HAN, William A. GODDARD, III, Marwa Ben HAJ SALAH, Lisa SCHERER, John J. ROSSI
Filed: 10 Feb 21
Utility
Cancer Detection and Ablation System and Method
29 Jul 21
Systems and methods are configured to detect and/or ablate cancerous tissue, such as during surgery.
Yuman Fong, Michael Storrie-Lombardi, Veronica Jones, Daniel Schmolze, Lily L. Lai, Ragini Kothari
Filed: 30 Apr 19
Utility
Masked Cytokine Conjugates
22 Jul 21
Provided herein are, inter alia, recombinant cytokine receptor binding proteins including a cytokine domain bound to an occlusion domain and a receptor domain through a first and second linker, respectively.
John C. WILLIAMS, Miso PARK
Filed: 23 Aug 19
Utility
Lighting and optics surgical system
20 Jul 21
Disclosed are lighting and optical devices, systems, and methods for use in laparoscopic surgical procedures.
Yuman Fong
Filed: 30 Apr 19
Utility
Methods of Reprogramming Somatic Cells and Materials Related Thereto
15 Jul 21
Disclosed herein are methods for reprogramming a somatic cell into a pluripotent stem cell by contacting the somatic cell with one or more antifolate agents, with or without methionine, in vitro for a period of time sufficient to reprogramming the somatic cell and selecting and growing the cells that express one or more stem cell markers.
Arthur D. RIGGS, Avinash C. SRIVASTAVA, Timothy R. O'CONNOR
Filed: 17 Nov 20
Utility
Macrocyclic lactones and uses thereof as modulators of purinergic receptors
13 Jul 21
Described herein, inter alia, are macrocyclic lactones such as ivermectin and methods for their use in treating, for example, hyperproliferative disorders such as cancer.
Peter P. Lee, Dobrin Draganov
Filed: 28 Oct 16
Utility
STAT3 Inhibitors and Uses Thereof
8 Jul 21
Described herein, inter alia, are STAT-binding nucleic acids-including compositions and methods of using the same.
Marcin Tomasz Kortylewski, Piotr Marek Swiderski
Filed: 14 Oct 20
Utility
Methods of identifying SENP1 inhibitors
22 Jun 21
Provided herein are methods of detecting binding of an SENP1 polypeptide to a compound and methods for screening for inhibitors of SENP1.
Yuan Chen, Chih-Hong Chen, Andrew Namanja
Filed: 13 Oct 17
Utility
Mva Vaccine for Delivery of a UL128 Complex and Preventing CMV Infection
17 Jun 21
In one embodiment, an expression system for expressing a UL128 complex is provided herein.
Don J. DIAMOND, Felix WUSSOW
Filed: 20 Nov 20
Utility
CS1 Targeted Chimeric Antigen Receptor-modified T Cells
10 Jun 21
Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.
Xiuli Wang, Stephen J. Forman
Filed: 13 Aug 20
Utility
Biomarkers for Cancer Immunotherapy Outcomes
3 Jun 21
Provided herein, inter alia, are improved methods and systems of determining immunotherapy response in subjects prior and during treatment.
Andrea BILD, Jason I. GRIFFITHS
Filed: 2 Dec 20
Utility
Anti-cancer Phosphorothioate-coupled Peptide Conjugates and Methods of Using the Same
27 May 21
Provided herein are, inter alia, nucleic acid-peptide conjugates including a non-cell penetrating protein (e.g., an Hdm2 targeting peptide) attached at its C-terminus to a phosphorothioate nucleic acid.
Andreas HERRMANN, Hua YU, Yanwen FU
Filed: 13 Jul 18