171 patents
Page 2 of 9
Utility
MVA vaccine for delivery of a UL128 complex and preventing CMV infection
8 Aug 23
In one embodiment, an expression system for expressing a UL128 complex is provided herein.
Don J. Diamond, Felix Wussow
Filed: 20 Nov 20
Utility
Biomarkers for cancer immunotherapy outcomes
25 Jul 23
Provided herein, inter alia, are improved methods and systems of determining immunotherapy response in subjects prior and during treatment.
Andrea Bild, Jason I. Griffiths
Filed: 2 Dec 20
Utility
Chimeric antigen receptors and methods for reducing toxicity
18 Jul 23
Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3ζ signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.
Xiuli Wang, Stephen J. Forman, Lawrence Stern, Christine E. Brown, Joseph Cohen
Filed: 25 Jan 19
Utility
Nanoparticle-cell construct with platinum anti-cancer agent
11 Jul 23
The disclosure provides, inter alia, compositions including cell-nanoparticle constructs and drug loaded nanoparticles, and methods for their use in the treatment of cancer.
Pengpeng Cao, Jacob Berlin, Karen Aboody, Rachael Mooney, Wafa Abidi
Filed: 28 Dec 16
Utility
Use of endogenous viral vaccine in chimeric antigen receptor T cell therapy
4 Jul 23
Provided herein are, inter alia, methods and compositions including T cells expressing (i) a recombinant CAR protein which includes a peptide binding site and is capable of specifically binding cancer-specific antigens and (ii) a T cell receptor specific for a viral antigen (e.g., a CMV pp65 protein).
John C. Williams, Christine Brown, Don J. Diamond
Filed: 2 Sep 21
Utility
Detection and treatment of neurological diseases
27 Jun 23
Disclosed are methods of detecting abnormal expression of one or more genes associated with a neurological disease such as the Alexander disease, the Alzheimer's disease, the Parkinson disease, the Huntington disease, multiple sclerosis, and amyotrophic lateral sclerosis.
Yanhong Shi, Li Li
Filed: 8 Jul 19
Utility
Hand-held grasping device
30 May 23
A hand tool has a pivot connection pivotally attaching a first arm to a second arm, with the pivot connection fixed relative to the first arm and movable to first and second positions relative to the second arm.
Gagandeep Singh
Filed: 25 Sep 20
Utility
Cell penetrating protein-antibody conjugates and methods of use
30 May 23
Provided herein are cell penetrating conjugates.
Andreas Herrmann, Hua Yu
Filed: 5 Aug 16
Utility
Methods for intracellular delivery and enhanced gene targeting
9 May 23
Disclosed herein are methods and compositions for enhancing gene targeting.
Daniela Castanotto, Cy Stein, Xiaowei Zhang
Filed: 15 Nov 17
Utility
Conditional-siRNAS and uses thereof in treating acute myeloid leukemia
9 May 23
Disclosed herein are conditional siRNAs activatable by CBFβ-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML).
Guido Marcucci, Ya-Huei Kuo, Si-ping Han, Lisa Scherer, William A. Goddard, III, John Rossi
Filed: 10 Feb 20
Utility
Method for determining lymphoma type and providing treatment
9 May 23
In embodiments of the invention, the invention provides a method for distinguishing between lymphoma types based on gene expression measurements.
Louis M. Staudt, Christian Steidl, Anja Mottok, George W. Wright, David William Scott, Lisa M. Rimsza, Andreas Rosenwald, Randy Gascoyne, Timothy Greiner, Dennis Weisenburger, Erlend B. Smeland, Jan Delabie, Elias Campo Guerri, German Ott, Rita Braziel, Elaine S. Jaffe, Kai Fu, Wing C. Chan, Joo Song, James R. Cook
Filed: 13 Dec 19
Utility
Composition and method for activating latent human immunodeficiency virus (HIV)
4 Apr 23
Provided are compositions and methods for activating latent Human Immunodeficiency Virus (HIV).
Kevin V. Morris, Marc S. Weinberg, Tristan Scott, Daniel Lazar
Filed: 22 Oct 18
Utility
Multi-modal image-guided radiation system
21 Mar 23
Systems and methods relate to multi-modal imaging of tissue combined with highly focused radiation interventions.
Susanta K. Hui, Gultekin Gulsen, Farouk Nouizi
Filed: 28 May 20
Utility
Anti-cancer phosphorothioate-coupled peptide conjugates and methods of using the same
21 Mar 23
Provided herein are, inter alia, nucleic acid-peptide conjugates including a non-cell penetrating protein (e.g., an Hdm2 targeting peptide) attached at its C-terminus to a phosphorothioate nucleic acid.
Andreas Herrmann, Hua Yu, Yanwen Fu
Filed: 13 Jul 18
Utility
P53-targeting vaccines and pd-1 pathway inhibitors and methods of use thereof
14 Mar 23
The disclosure provides, inter alia, methods and materials involved in treating cancer using a p53 vaccine in combination with a PD-1 pathway inhibitor.
Don J. Diamond
Filed: 8 Dec 17
Utility
Methods for detection of botulinum neurotoxin
14 Mar 23
Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin.
Markus Kalkum, Karine Bagramyan
Filed: 14 Sep 20
Utility
Antibody variable domains and antibody constructs
7 Mar 23
Provided herein are, inter alia, compositions and methods for the treatment of cancer.
Hong Qin, Larry W. Kwak, Guowei Wei
Filed: 4 May 18
Utility
Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
28 Feb 23
The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.
Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Guido Marcucci, Bin Zhang, Ya-Huei Kuo
Filed: 2 Sep 20
Utility
Compound for treating cancer and diabetes
21 Feb 23
One aspect of the disclosure relates to the use of derivatives of dichlorophenyl urea for treating cancers.
Samuel Rahbar, James L. Figarola, Christopher Lincoln, David Horne, Rachael Mooney, Monika Polewski, George Somlo, Lixin Yang, Sanjay Awasthi, Sharad Singhal, Jyotasana Singhal
Filed: 6 Nov 17
Utility
Dithio ETP derivatives
21 Feb 23
Disclosed herein, inter alia, are compositions and methods of using the same for the treatment of cancer.
Sangkil Nam, David Horne, Larry Eugene Overman, Brad Loertscher
Filed: 23 Sep 20