171 patents
Page 4 of 9
Utility
Twist signaling inhibitor compositions and methods of using the same
9 Aug 22
The present invention relates to compositions comprising TWIST signaling inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
Carlotta A. Glackin, John J. Rossi, Jeffrey I. Zink, Fuyuhiko Tamanoi, Cai M. Roberts, James Finlay
Filed: 22 Nov 19
Utility
Epstein-Barr virus antibodies and uses thereof
2 Aug 22
Disclosed herein are antibodies or immunogenic fragments thereof that specifically bind to Epstein-Barr virus (EBV) glycoprotein 350 (gp350) or 220 or one or more epitopes of EBV gp350 and neutralize EBV infection.
Javier Gordon Ogembo, Lorraine Zvichapera Mutsvunguma, Alison Evelynn Ondrus
Filed: 27 Apr 18
Utility
Methods and compositions for treating endometrial cancer
19 Jul 22
Provided herein are, inter alia, methods and compositions for treating cancer in a subject in need thereof comprising a therapeutically effective amount of a stilbenoid compound and a progestin.
Thanh Dellinger
Filed: 14 Sep 18
Utility
Expression system for expressing herpesvirus glycoprotein complexes
19 Jul 22
An expression system for expressing a herpesvirus glycoprotein complex including a vector inserted with two or more nucleic acid sequences that encode two or more subunits of a herpesvirus glycoprotein complex linked by one or more linking sequences such that the subunits are co-expressed simultaneously and self-processed to assemble into a glycoprotein complex.
Felix Wussow, Don J. Diamond
Filed: 13 Jul 18
Utility
MVA-gH/gL-PC vaccine derived antibodies neutralizing human cytomegalovirus infectivity and methods thereof
12 Jul 22
Vaccine-derived neutralizing antibodies (NAbs) for CMV infections and small peptides which define precise recognition elements of the antigens by the NAbs.
Don J. Diamond, Flavia Chiuppesi, Felix Wussow
Filed: 11 Nov 19
Utility
Energy-enhanced, hand-held vascular sealer
14 Jun 22
A hand tool has a pivot connection pivotally attaching a first arm to a second arm, with the pivot connection fixed relative to the first arm and movable to first and second positions relative to the second arm.
Gagandeep Singh
Filed: 1 Nov 18
Utility
PCNA inhibitors
31 May 22
Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
Linda H. Malkas, David Horne, Robert J. Hickey, Long Gu
Filed: 1 Dec 20
Utility
TXNIP-TRX complex inhibitors and methods of using the same
10 May 22
Disclosed herein, inter alia, are compounds and methods for inhibiting the thioredoxin-thioredoxin-interacting-protein (TXNIP-TRX) complex.
Rama Natarajan, Feng Miao, Nagarajan Vaidehi, Supriyo Bhattacharya, Adrien Beau Larsen
Filed: 13 Sep 19
Utility
Methods for treating breast and other cancers by targeting argininosuccinate synthetase 1-deficiency
26 Apr 22
Autophagy is the principal catabolic response to nutrient starvation.
David K. Ann, Yun-Ru Chen, Fuming Qiu
Filed: 1 Apr 16
Utility
Development of masked therapeutic antibodies to limit off-target effects
26 Apr 22
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof.
John C. Williams, Cindy Zer, Kendra N. Avery, Ulrich Rodeck, Joshua M. Donaldson, Csaba Kari
Filed: 2 Jul 19
Utility
5-bromo-indirubins
19 Apr 22
Disclosed herein inter alia are compositions and methods for treating cancer using 5-Br-indirubin derivatives.
Richard Jove, Sangkil Nam, David Horne, Jun Xie, Alexios Leandros Skaltsounis, Marina Kritsanida, Nicolas Gaboriaud-Kolar
Filed: 13 Feb 20
Utility
Adeno-associated virus compositions for restoring F8 gene function and methods of use thereof
19 Apr 22
Provided herein are adeno-associated virus (AAV) compositions that can restore F8 gene function in a cell without co-transducing or co-administering an exogenous nuclease or a nucleotide sequence that encodes an exogenous nuclease.
Saswati Chatterjee, Laura Jane Smith, Jeff Lynn Ellsworth, Hillard Rubin, Jason Boke Wright, James Anthony McSwiggen
Filed: 19 Feb 19
Utility
Chimeric immunoreceptor useful in treating human cancers
22 Mar 22
The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain.
Michael Jensen
Filed: 20 Dec 19
Utility
Tumor-selective CTLA-4 antagonists
22 Mar 22
Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular disease.
John C. Williams, Ulrich Rodeck, Kurt Jenkins
Filed: 3 Sep 19
Utility
Methods of quantifying N
8 Mar 22
Methods of quantifying N2-carboxyethyl-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer.
Samuel Rahbar, Timothy W. Synold, John Termini, Daniel Tamae, Gerald Wuenschell
Filed: 29 Dec 17
Utility
Markers of breast cancer and methods for the use thereof
8 Mar 22
In accordance with the present invention, the single gene SERPINA1 has been identified as a significant predictor of survival in ER+ and ER+/HER2+ breast cancer patients.
Shiuan Chen, Hei Jason Chan
Filed: 19 Jan 16
Utility
Anti-cancer RNA aptamers
1 Mar 22
Provided herein, inter alia, are compounds capable of binding HSP70 (e.g. mHSP70) on a cell and internalizing into said cell.
John J. Rossi, Sorah Yoon, Nagy Habib
Filed: 18 Dec 19
Utility
Methods and compositions for measuring beta cell death
1 Mar 22
Provided herein are, inter alia, nucleic acids, methods, and kits for detecting unmethylated DNA in body fluid sample of a subject.
Kevin Ferreri, Mohamed I. Husseiny Elsayed
Filed: 8 Jul 19
Utility
Meditopes and meditope-binding antibodies and uses thereof
15 Feb 22
Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
John C. Williams, David A. Horne, Yuelong Ma, Heng Wei Chang, Joshua Michael Donaldson, Cindy Zer, Krzysztof Bzymek, Kendra Nicole Avery, Jun Xie
Filed: 5 Jun 17
Utility
Compositions and methods for the treatment of hypercholesterolemia
8 Feb 22
Provided herein are, inter alia, compositions and methods for the treatment of hypercholesterolemia.
Kevin V. Morris, Roslyn Ray
Filed: 2 Feb 18