171 patents
Page 7 of 9
Utility
Peptide inhibitors of twist
16 Mar 21
The disclosure provides, inter alia, compositions comprising TWIST peptide inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
Carlotta A. Glackin
Filed: 8 Apr 20
Utility
Lighting and optics surgical system
2 Mar 21
Lighting and optical devices, systems, and methods are configured for use in laparoscopic surgical procedures.
Yuman Fong
Filed: 30 Apr 19
Utility
PCNA inhibitors
9 Feb 21
Described herein, inter alia, are compositions of PCNA modulators and methods for treating or preventing cancer.
Linda H. Malkas, David Horne, Robert J. Hickey, Long Gu
Filed: 13 Dec 19
Utility
Isolated human cell with an inactivated glucocorticoid receptor gene
2 Feb 21
Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR.
Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
Filed: 20 Nov 15
Utility
Methods of treating pancreatic cancer using GPCR antagonists
30 Nov 20
Provided herein are, inter alia, compositions and methods for the treatment of cancer and inhibition of metastasis.
Tijana Talisman, Sunetra Biswas
Filed: 27 Sep 17
Utility
MVA vaccine for delivery of a UL128 complex and preventing CMV infection
23 Nov 20
In one embodiment, an expression system for expressing a UL128 complex is provided herein.
Don J. Diamond, Felix Wussow
Filed: 11 Aug 19
Utility
Artificial urinary sphincter device
9 Nov 20
An artificial urinary sphincter device is configured to be implanted in a relationship with a patient's urethra for the treatment of urinary incontinence.
Cassandra Rose Joung Meyer, Sophia Rose Williams, Jonathan Robert Wong, Meijing Maggie Liu, Risa Tom Egerter, Kevin Chan, Lori C. Bassman
Filed: 11 Oct 18
Utility
STAT3 inhibitors and uses thereof
9 Nov 20
Described herein, inter alia, are STAT-binding nucleic acids-including compositions and methods of using the same.
Marcin Tomasz Kortylewski, Piotr Marek Swiderski
Filed: 17 May 18
Utility
CS1 targeted chimeric antigen receptor-modified T cells
2 Nov 20
Chimeric antigen receptors for use in treating malignant melanoma and other cancers expressing CS1 are described.
Xiuli Wang, Stephen J. Forman
Filed: 6 Dec 15
Utility
Dithio ETP derivatives
2 Nov 20
Disclosed herein, inter alia, are compositions and methods of using the same for the treatment of cancer.
Sangkil Nam, David Horne, Larry Eugene Overman, Brad Loertscher
Filed: 14 Sep 17
Utility
Short hairpin RNA compositions, methods of making and applications thereof
19 Oct 20
Provided herein are novel synthetic short hairpin RNA (shRNA) molecules and compositions and kits comprising such molecules, as well as methods of making and using these molecules, compositions, and kits.
Guihua Sun
Filed: 21 Oct 18
Utility
Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
12 Oct 20
The present disclosure relates to a compound including a nucleic acid sequence conjugated to an anti-microRNA or a microRNA-mimic or a compound including a modified anti-microRNA sequence, compositions of such a compound, and method of treatment of a disease, and method of suppressing microRNA activity by the disclosed compound or composition.
Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Guido Marcucci, Bin Zhang, Ya-Huei Kuo
Filed: 13 Oct 16
Utility
Methods and compositions for treatment of breast cancer
5 Oct 20
Provided are methods of treating breast cancer in a subject in need thereof comprising administering to the subject an effective amount of an inhibitor of miR-105 or an inhibitor of miR-122 are provided.
Shizhen Emily Wang, Xiwei Wu
Filed: 9 Mar 14
Utility
Compounds of chemically modified oligonucleotides and methods of use thereof
28 Sep 20
The present disclosure relates to isolated compounds including a nucleic acid sequence capable of hybridizing to an RNA sequence 10 to 270 nucleobases downstream of the transcription start site of a mammalian microRNA-379 transcript; method of treating diabetic nephropathy in a subject with the compounds; and method of inhibiting expression of a mammalian microRNA-379 megacluster with the compounds.
Rama Natarajan, Mitsuo Kato
Filed: 24 May 16
Utility
Substrates for detection of botulinum neurotoxin
14 Sep 20
Provided herein is a large immuno-sorbent surface area assay (ALISSA) for the rapid and sensitive detection of botulinum neurotoxins (BoNTs) and anthrax toxin.
Markus Kalkum, Karine Bagramyan
Filed: 5 Feb 17
Utility
Compositions of and methods of treatment with zwitterionic polysaccharide
7 Sep 20
The present disclosure includes compositions of a zwitterionic polysaccharide (e.g., B. fragilis capsular polysaccharide A (PSA)) (including active fragments thereof) and methods of treating viral infection and viral infection associated inflammation with compositions of a zwitterionic polysaccharide (e.g., B. fragilis capsular polysaccharide A (PSA)) (including active fragments thereof).
Edouard Cantin, Sarkis K. Mazmanian, Chandran Ramakrishna
Filed: 9 Jun 16
Utility
Chemically encoded spatially addressed library screening platforms
7 Sep 20
Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.
Jacob Berlin, Gregory Copeland, Kathleen Elison, Hurik Muradyan
Filed: 28 Aug 19
Utility
Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof
31 Aug 20
The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.
Marcin Tomasz Kortylewski, Piotr Marek Swiderski, Dayson Friaca Moreira
Filed: 29 Jun 16
Utility
NIR-conjugated tumor-specific antibodies and uses thereof
31 Aug 20
Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors.
Paul Yazaki, Jack Shively, Michael Bouvet, Jonathan Delong, Yuman Fong
Filed: 24 Jan 18
Utility
Chemically encoded spatially addressed library screening platforms
31 Aug 20
Provided herein are encoded split pool libraries useful, inter alia, for forming highly diverse and dense arrays for screening and detection of a variety of molecules.
Jacob Berlin, Gregory Copeland, Kathleen Elison, Hurik Muradyan
Filed: 23 Feb 16