13 patents
Utility
Methylation-based false positive duplicate marking reduction
3 Oct 23
An analytics system marks duplicate fragments from an initial set of fragments from a subject.
Alexander S. Yip, Samuel S. Gross, Seyedmehdi Shojaee
Filed: 3 Apr 20
Utility
Diagnostic applications using nucleic acid fragments
25 Oct 22
Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam
Filed: 24 Apr 20
Utility
Alignment free filtering for identifying fusions
18 Oct 22
Cell free nucleic acids from a test sample obtained from an individual are analyzed to identify possible fusion events.
Xiao Yang, Hyunsung John Kim, Wenying Pan, Matthew H. Larson, Eric Michael Scott, Pranav Parmjit Singh, Mohini Jangi Desai
Filed: 12 Jun 18
Utility
Methods and systems for tumor detection
4 Oct 22
Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples.
Eugeni Namsaraev, Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Kun Sun, Wai Kei Lam
Filed: 25 Oct 17
Utility
Methods for enriching for duplex reads in sequencing and error correction
16 Aug 22
Methods for preparing sequencing libraries from a DNA-containing test sample, as well as methods for correcting sequencing-derived errors, are provided.
Lijuan Ji, Nathan Hunkapiller, Suchitra Ramani
Filed: 14 Dec 18
Utility
Enhanced ligation in sequencing library preparation
15 Mar 22
Methods for preparing a sequencing library from a DNA-containing test sample are provided.
Craig Betts, Byoungsok Jung
Filed: 30 Mar 18
Utility
Using nucleic acid size range for noninvasive cancer detection
9 Nov 21
Size-band analysis is used to determine whether a chromosomal region exhibits a copy number aberration or an epigenetic alteration.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang
Filed: 1 Nov 18
Utility
Higher target capture efficiency using probe extension
14 Sep 21
Aspects of the invention include methods for preparing an enriched sequencing library.
Nicholas Eattock, Byoungsok Jung, Justice Williams
Filed: 30 Mar 18
Utility
Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
2 Feb 21
Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules.
Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
Filed: 24 Oct 19
Utility
Methods for single-stranded nucleic acid library preparation
2 Nov 20
Aspects of the invention relate to methods and compositions for preparing and analyzing a single-stranded sequencing library from a double-stranded DNA (e.g., double-stranded cfDNA) sample.
Arash Jamshidi, Hamed Amini
Filed: 26 Oct 17
Utility
Diagnostic applications using nucleic acid fragments
27 Apr 20
Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam
Filed: 24 Jan 18
Utility
Methods of analyzing nucleic acid fragments
20 Apr 20
Provided herein are methods for enriching a biological sample for a target nucleic acid, and analyzing the nucleic acid.
Eugeni Namsaraev, Maneesh Jain
Filed: 9 Aug 17
Utility
Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
25 Nov 19
Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules.
Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
Filed: 21 Sep 17
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