71 patents
Utility
Analysis of Microbial Fragments In Plasma
11 Jan 24
Various embodiments are directed to detecting infection-causing microbial cell-free DNA from a biological sample based on their size profiles and/or end signatures, in which the detection of infection-causing microbial DNA can be performed without no template control (NTC) samples.
Yuk-Ming Dennis Lo, Kwan Chee Chan, Rossa Wai Kwun Chiu, Wai Kei Lam, Peiyong Jiang, Guangya Wang
Filed: 8 Jul 22
Utility
Diagnostic Applications Using Nucleic Acid Fragments
18 May 23
Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam
Filed: 18 Oct 22
Utility
Methods and Systems for Tumor Detection
4 May 23
Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples.
Eugeni Namsaraev, Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Kun Sun, Wai Kei Lam
Filed: 9 Aug 22
Utility
Sequencing of Viral Dna for Predicting Disease Relapse
6 Apr 23
Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses.
Yuk-Ming Dennis Lo, Kwan Chee Chan, Wai Kei Lam, Chiu Tung Chan
Filed: 30 Sep 22
Utility
Cell-free Dna Methylation and Nuclease-mediated Fragmentation
15 Dec 22
Nuclease activity can affect the methylation level and fragmentation of cfDNA.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wing Yan Chan, Meng Ni, Diana Siao Cheng Han, Tsz Kwan Sin
Filed: 8 Apr 22
Utility
Methods for Enriching for Duplex Reads In Sequencing and Error Correction
3 Nov 22
Methods for preparing sequencing libraries from a DNA-containing test sample, as well as methods for correcting sequencing-derived errors, are provided.
Lijuan Ji, Nathan Hunkapiller, Suchitra Ramani
Filed: 29 Jun 22
Utility
Methods of Identifying Somatic Mutational Signatures for Early Cancer Detection
20 Oct 22
Aspects of the invention include methods and systems for identifying somatic mutational signatures for detecting, diagnosing, monitoring and/or classifying cancer in a patient known to have, or suspected of having cancer.
Oliver Claude Venn, III
Filed: 21 Jun 22
Utility
Methods Using Characteristics of Urinary and Other Dna
9 Jun 22
The ends of cell-free DNA fragments may be used for analysis of a biological sample.
Yuk-Ming Dennis Lo, Kwan Chee Chan, Peiyong Jiang, Suk Hang Cheng, Ze Zhou, Tingting Xie, Guangya Wang, Chen Ding
Filed: 7 Dec 21
Utility
Sample Validation for Cancer Classification
24 Mar 22
Systems and methods for validating that a DNA sample is from a test subject are disclosed.
Onur Sakarya, Christopher-James A.V. Yakym
Filed: 26 Aug 21
Utility
Detecting Cross-contamination In Sequencing Data
24 Mar 22
Detecting cross-contamination between test samples used for determining cancer in a subject is beneficial.
ONUR SAKARYA, CHRISTOPHER-JAMES A.V. YAKYM, PRANAV PARMJIT SINGH, ROBERT ABE PAINE CALEF, RICHARD HUANG
Filed: 17 Sep 21
Utility
Using Nucleic Acid Size Range for Noninvasive Cancer Detection
3 Mar 22
Size-band analysis is used to determine whether a chromosomal region exhibits a copy number aberration or an epigenetic alteration.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang
Filed: 8 Nov 21
Utility
Nuclease-associated End Signature Analysis for Cell-free Nucleic Acids
13 Jan 22
Various embodiments are directed to using nuclease expression in tissues that influences cell-free DNA end signatures/motifs and size of overhang between DNA strands.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wing Yan Chan, Wai Kei Lam, Diana Siao Cheng Han, Wenlei Peng, Chen Ding
Filed: 13 Jul 21
Utility
Detection and Classification of Human Papillomavirus Associated Cancers
23 Dec 21
Systems and methods described herein include detecting a presence or absence of HPV in a biological sample having cell-free nucleic acids from a subject and potentially cell-free nucleic acids from an HPV strain.
Robert Abe Paine Calef, M. Cyrus Maher, John F. Beausang, Joerg Bredno, Oliver Claude Venn, Alexander P. Fields, Arash Jamshidi
Filed: 17 Jun 21
Utility
Methods for Analysis of Cell-free Rna
16 Dec 21
Methods for measuring subpopulations of cell-free ribonucleic acid (RNA) molecules are provided.
Ruth E. MAUNTZ, Matthew LARSON, Archana SHENOY, Arash JAMSHIDI, David BURKHARDT
Filed: 16 Jun 21
Utility
Systems and Methods for Cancer Condition Determination Using Autoencoders
18 Nov 21
A method for discriminating a cancer state is provided.
Virgil Nicula, Joshua Newman
Filed: 4 Mar 21
Utility
Cancer Classification Using Patch Convolutional Neural Networks
21 Oct 21
Methods for determining a disease condition of a subject of a species are provided that comprises obtaining a dataset of fragment methylation patterns determined by methylation sequencing of nucleic acid from a biological sample of the subject.
Virgil Nicula, Ognjen Nikolic, Yasushi Saito, Marius Eriksen, Josh Newman, Darya Filippova, Alexander Yip, Oliver Venn, Joerg Bredno, Qinwen Liu, Alexander P. Fields
Filed: 11 Dec 20
Utility
Generating Cancer Detection Panels According to a Performance Metric
21 Oct 21
A system generates a cancer detection panel.
Jing Xiang, Anton Valouev
Filed: 19 Apr 21
Utility
Cancer Classification with Synthetic Training Samples
7 Oct 21
Methods and systems for detecting cancer and/or determining a cancer tissue of origin are disclosed.
M. Cyrus Maher, Samuel S. Gross, Joshua Newman, Joerg Bredno, Ognjen Nikolic
Filed: 29 Mar 21
Utility
Cancer Classification with Genomic Region Modeling
7 Oct 21
Methods and systems for detecting cancer and/or determining a cancer tissue of origin are disclosed.
Samuel S. Gross, Joshua Newman, Virgil Nicula
Filed: 29 Mar 21
Utility
Systems and Methods for Estimating Cell Source Fractions Using Methylation Information
23 Sep 21
A method of identifying a plurality of features for estimating subject cell source fraction is provided.
Jing XIANG, Robert Abe Paine Calef
Filed: 18 Dec 20