71 patents
Page 2 of 4
Utility
Identifying Methylation Patterns That Discriminate or Indicate a Cancer Condition
23 Sep 21
Systems and methods of identifying methylation patterns discriminating or indicating a cancer condition are provided.
Collin Melton, Earl Hubbell, Oliver Claude Venn
Filed: 26 Feb 21
Utility
Systems and Methods for Calling Variants Using Methylation Sequencing Data
16 Sep 21
An allelic position variant calling method using a prior genotype probability at the allelic position is provided.
Pranav Singh, Christopher Chang, Collin Melton, Oliver Claude Venn
Filed: 25 Feb 21
Utility
Method for Accurate Quantification of Genomic Copies In Cell-free Dna
9 Sep 21
Described herein are methods and systems for quantifying low molecular weight nucleic acid molecules in a biological sample amongst a background of high molecular weight contamination.
Hamed AMINI, Sudha NAGARAJU, Alex ARAVANIS, Arash JAMSHIDI
Filed: 11 Aug 17
Utility
Biterminal Dna Fragment Types In Cell-free Samples and Uses Thereof
5 Aug 21
The present disclosure describes techniques for measuring quantities (e.g., relative frequencies) of end motif pairs of cell-free DNA fragments in a biological sample of an organism for measuring a property of the sample (e.g., fractional concentration of clinically-relevant DNA) and/or determining a pathology of the organism based on such measurements.
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Diana Siao Cheng Han, Meng Ni
Filed: 7 Jan 21
Utility
Methylation Markers and Targeted Methylation Probe Panel
5 Aug 21
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. GROSS, Oliver Claude VENN, Seyedmehdi SHOJAEE, John BEAUSANG, Arash JAMSHIDI
Filed: 26 Mar 21
Utility
Methylation Markers and Targeted Methylation Probe Panel
5 Aug 21
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. GROSS, Oliver Claude VENN, Seyedmehdi SHOJAEE, John BEAUSANG, Arash JAMSHIDI
Filed: 26 Mar 21
Utility
Methods for Tagging and Amplifying Rna Template Molecules for Preparing Sequencing Libraries
1 Jul 21
Aspects of the invention include methods for preparing sequencing libraries comprising a plurality of RNA molecules.
Matthew Larson
Filed: 10 Mar 21
Utility
Systems and Methods for Evaluating Longitudinal Biological Feature Data
3 Jun 21
Systems and methods are provided for determining whether a test subject has a disease condition.
M. Cyrus Maher, Alex Aravanis, Angela Lai, Oliver Claude Venn, Richard Rava, Jing Xiang, Joseph Marcus
Filed: 25 Nov 20
Utility
Endpoint Analysis In Early Cancer Detection
6 May 21
A system and method for determining a presence of cancer in a test sample from a test subject comprising a set of fragments of deoxyribonucleic acid (DNA) is described.
Peter D. Freese, Collin Melton, Earl Hubbell
Filed: 9 Oct 20
Utility
Cancer Classification with Tissue of Origin Thresholding
29 Apr 21
Methods and systems for detecting cancer and/or determining a cancer tissue of origin are disclosed.
Qinwen Liu, Oliver Claude Venn, Samuel S. Gross, Robert Abe Paine Calef
Filed: 9 Oct 20
Utility
Methods of Preparing and Analyzing Cell-free Nucleic Acid Sequencing Libraries
22 Apr 21
Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules.
Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
Filed: 23 Dec 20
Utility
Systems and Methods for Using Pathogen Nucleic Acid Load to Determine Whether a Subject Has a Cancer Condition
22 Apr 21
Methods for screening for a cancer condition in a subject are provided.
M. Cyrus Maher, Anton Valouev, Seyedmehdi Shojaee, Oliver Claude Venn
Filed: 24 Apr 19
Utility
Systems and Methods for Diagnosing a Disease Condition Using On-target and Off-target Sequencing Data
8 Apr 21
Systems and methods for determining whether a subject has a disease condition in a set of disease conditions are provided.
Anton Valouev, Jing Xiang, Collin Melton
Filed: 16 Sep 20
Utility
Systems and Methods for Determining Tumor Fraction In Cell-free Nucleic Acid
8 Apr 21
Systems and methods are disclosed for determining tumor fraction in cell-free nucleic acid of a liquid biological sample of a subject.
Oliver Claude VENN, Earl HUBBELL, Onur SAKARYA
Filed: 16 Apr 19
Utility
Methods and Systems for Screening for Conditions
25 Mar 21
Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples.
Rongsu QI, Farooq A. SIDDIQUI, Srinka GHOSH
Filed: 11 Sep 20
Utility
Systems and Methods for Determining Tumor Fraction
4 Mar 21
Systems and methods for determining a tumor fraction for a subject are provided.
Anton Valouev, Jing Xiang
Filed: 23 Jul 20
Utility
Systems and Methods for Determining Consensus Base Calls In Nucleic Acid Sequencing
4 Mar 21
Systems and methods for determining consensus base calls in nucleic acid sequencing are provided.
Anton Valouev, Shirley Chen, David Burkhardt, Christopher Chang
Filed: 28 Aug 20
Utility
Methylation Markers and Targeted Methylation Probe Panel
28 Jan 21
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. Gross, Hamid Amini, Arash Jamshidi, Seyedmehdi Shojaee, Srinka Ghosh, Rongsu Qi, M. Cyrus Maher, Alexander P. Fields, Oliver Claude Venn
Filed: 1 Oct 20
Utility
Methylation Markers and Targeted Methylation Probe Panel
21 Jan 21
The present description provides a cancer assay panel for targeted detection of cancer-specific methylation patterns.
Samuel S. Gross, Hamid Amini, Arash Jamshidi, Seyedmehdi Shojaee, Srinka Ghosh, Rongsu Qi, M. Cyrus Maher, Alexander P. Fields, Oliver Claude Venn
Filed: 1 Oct 20
Utility
Determining Linear and Circular Forms of Circulating Nucleic Acids
30 Dec 20
Techniques are provided for analyzing circular DNA in a biological sample (e.g., including cell-free DNA, such as plasma).
Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Lu Ji, Tsz Kwan Sin, Haiqiang Zhang, Jiaen Deng
Filed: 24 Mar 20