25 patents
Page 2 of 2
Utility
Compositions and Methods for Generating Hair Cells by Upregulating JAG-1
11 Mar 20
Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
Christopher Loose, Will McLean, Megan Harrison
Filed: 18 Aug 19
Utility
Compositions and Methods for Generating Hair Cells by Upregulating PI3K
11 Mar 20
Provided are compositions and methods comprising PI3K agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
Christopher LOOSE, Will MCLEAN, Megan HARRISON
Filed: 18 Aug 19
Utility
Compositions and Methods for Generating Hair Cells by Downregulating Foxo
11 Mar 20
Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
Christopher LOOSE, Will MCLEAN, Megan HARRISON, Melissa HILL-DRZEWI
Filed: 18 Aug 19
Utility
1H-PYRROLE-2,5-DIONE Compounds and Methods of Using Them to Induce Self-renewal of Stem/progenitor Supporting Cells
20 Nov 19
The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN
Filed: 20 Dec 17
Utility
Compositions and Methods for Increasing Remyelination
6 Nov 19
Provided are compositions and methods comprising a MAChR antagonist/inverse agonist/partial agonist and a histamine H3 receptor antagonist/inverse agonist/partial agonist for increasing proliferation Oligodendrocyte Progenitor Cells (OPCs) into mature, myelinating oligodendrocytes, and related methods of treating demyelination disorders.
Bradley TAIT, Michael R. JIROUSEK, Christopher LOOSE, William W. CHIN
Filed: 4 Apr 19