14 patents
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Engineered Aryl Sulfate-dependent Enzymes
4 Jan 24
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA, Daniel H. LAJINESS
Filed: 24 Jul 23
Utility
Methods for Synthesizing Anticoagulant Polysaccharides
26 Oct 23
The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors.
Tarsis Ferriera Gesteira, Daniel H. Lajiness
Filed: 17 Apr 23
Utility
Engineered Aryl Sulfate-dependent Enzymes
18 May 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Ferreira GESTEIRA, Daniel H. LAJINESS
Filed: 13 Jan 23
Utility
Engineered Aryl Sulfate-dependent Enzymes
23 Mar 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3 ‘-phosphoadenosine 5’-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA, Daniel H. Lajiness
Filed: 24 Aug 22
Utility
Engineered Aryl Sulfate-dependent Enzymes
16 Feb 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA, Daniel H. Lajiness
Filed: 24 Aug 22
Utility
Engineered Aryl Sulfate-dependent Enzymes
26 Jan 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA, Daniel H. LAJINESS
Filed: 24 Aug 22
Utility
Engineered Aryl Sulfate-dependent Enzymes
26 Jan 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Daniel H. LAJINESS, Tarsis Gesteira FERREIRA
Filed: 21 Sep 22
Utility
Methods for Synthesizing Anticoagulant Polysaccharides
19 Jan 23
The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors.
Tarsis Ferriera Gesteira, Daniel H. Lajiness
Filed: 24 Aug 22
Utility
CorrectedEngineered Aryl Sulfate-dependent Enzymes
27 Oct 22
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA
Filed: 15 Jul 21
Utility
Engineered Aryl Sulfate-dependent Enzymes
10 Feb 22
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA
Filed: 15 Jul 21
Utility
Methods for Synthesizing Anticoagulant Polysaccharides
13 Jan 22
The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors.
Tarsis Ferreira GESTEIRA, Daniel H. LAJINESS
Filed: 15 Jul 21
Utility
Engineered Aryl Sulfate-dependent Enzymes
25 Nov 21
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA
Filed: 15 Jul 21
Utility
Engineered Aryl Sulfate-dependent Enzymes
25 Nov 21
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA
Filed: 15 Jul 21
Utility
Engineered Aryl Sulfate-dependent Enzymes
25 Nov 21
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira FERREIRA
Filed: 15 Jul 21
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