10 patents
Utility
Engineered aryl sulfate-dependent enzymes
3 Oct 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira Ferreira, Daniel H. Lajiness
Filed: 24 Aug 22
Utility
Engineered aryl sulfate-dependent enzymes
26 Sep 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira Ferreira, Daniel H. Lajiness
Filed: 24 Aug 22
Utility
Engineered aryl sulfate-dependent enzymes
25 Jul 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Daniel H. Lajiness, Tarsis Gesteira Ferreira
Filed: 21 Sep 22
Utility
Engineered aryl sulfate-dependent enzymes
25 Jul 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira Ferreira, Daniel H. Lajiness
Filed: 24 Aug 22
Utility
Engineered aryl sulfate-dependent enzymes
4 Jul 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira Ferreira
Filed: 15 Jul 21
Utility
Methods for synthesizing anticoagulant polysaccharides
18 Apr 23
The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors.
Tarsis Ferriera Gesteira, Daniel H. Lajiness
Filed: 24 Aug 22
Utility
Engineered aryl sulfate-dependent enzymes
7 Feb 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira Ferreira
Filed: 15 Jul 21
Utility
Engineered aryl sulfate-dependent enzymes
7 Feb 23
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira Ferreira
Filed: 15 Jul 21
Utility
Methods for synthesizing anticoagulant polysaccharides
3 Jan 23
The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors.
Tarsis Ferreira Gesteira, Daniel H. Lajiness
Filed: 15 Jul 21
Utility
Engineered aryl sulfate-dependent enzymes
18 Oct 22
The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors.
Tarsis Gesteira Ferreira
Filed: 15 Jul 21
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