13 patents
Utility
Composition or method including (t)ew-7197 for treating or preventing corneal endothelial diseases
2 Jan 24
The present disclosure provides a composition for treating or preventing symptoms, disorders, or diseases of the corneal endothelium.
Noriko Koizumi, Naoki Okumura, Mayumi Yamamoto
Filed: 13 Dec 18
Utility
Composition for treatment and/or prevention of peripheral nerve disorder
19 Dec 23
Shinji Hirotsune
Filed: 22 May 17
Utility
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12 Dec 23
The invention provides an agent for promoting adhesion of a corneal endothelial cell, containing a Rho kinase inhibitor, as well as a culture medium for a corneal endothelial cell, a solution for preservation of cornea, and a method of producing a corneal endothelial preparation, which includes culturing the corneal endothelial cell using the aforementioned culture medium.
Noriko Koizumi, Shigeru Kinoshita, Morio Ueno
Filed: 9 Oct 15
Utility
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22 Aug 23
The present invention provides medicaments for treating or preventing a disease, disorder, or condition associated with extracellular matrix (ECM) abnormality in a corneal endothelium, wherein the medicaments comprise a TGF-beta signal inhibiting agent.
Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita
Filed: 30 Jul 13
Utility
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25 Apr 23
The invention provides an agent for promoting adhesion of a corneal endothelial cell, containing a Rho kinase inhibitor, as well as a culture medium for a corneal endothelial cell, a solution for preservation of cornea, and a method of producing a corneal endothelial preparation, which includes culturing the corneal endothelial cell using the aforementioned culture medium.
Noriko Koizumi, Shigeru Kinoshita, Morio Ueno
Filed: 9 Oct 15
Utility
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25 Apr 23
The present invention provides a technique for treating the cornea.
Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita
Filed: 30 Oct 15
Utility
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13 Sep 22
Provided are: emulsion eyedrops which have no concern with possible corneal injury induced by a nonionic surfactant, have excellent thermal stability and physical stability and can contain a sparingly water-soluble drug in an increased amount; and an emulsion eyedrops stabilization method.
Yasuhiro Mori
Filed: 16 Nov 17
Utility
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12 Jul 22
The present invention provides a treatment drug or prophylactic drug for diseases, disorders, or conditions related to endoplasmic reticulum (ER) stress.
Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita
Filed: 30 Oct 14
Utility
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30 Mar 21
The present invention provides an agent for treating or preventing a disease, a disorder or a condition of a corneal endothelium, said agent comprising a corneal endothelial cell and a myosin II-specific inhibitor.
Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita
Filed: 27 Dec 13
Utility
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13 Jul 20
Yuko Shikamura, Yuka Higashimura
Filed: 15 Apr 18
Utility
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1 Jun 20
The purpose of the present invention is to provide a polymer gel that can increase drug content ratio and reduce undesirable influence on gel strength and shape stability after the drug release, compared with the conventional techniques.
Haruka Obata, Kiyoshi Shoji, Yoshiko Yamazaki, Toru Matsunaga, Takao Sato, Wakiko Asayama, Shinichi Yasueda
Filed: 15 Apr 15
Utility
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25 May 20
A peptide which has a neuroprotective action, a neuroprotective drug and neuropathic treatment containing the peptide, and a preventive or alleviative pharmaceutical composition.
Takeshi Nakajima, Mamiko Machida, Yujiro Hayashi
Filed: 29 Mar 17
Utility
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18 May 20
There are provided a check valve structure that not only prevents backflow of fluid but does not discharge fluid for unintended pressure in a correct direction, and a squeeze container using the check valve structure.
Takahiro Murase, Tadashi Otsuka
Filed: 10 Nov 16
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