9 patents
Utility
Dynamic Human Antibody Light Chain Libraries
14 Sep 23
Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody light chain with specific hypervariable regions HVR-L1, HVR-L2, and HVR-L3.
Peter Peizhi LUO, Yan LI, Fangyong DU
Filed: 11 Jan 23
Utility
Anti-CSF1R Molecules and Use Thereof
29 Jun 23
The disclosure relates to antibodies against human CSF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Fangyong Du, Peter Peizhi Luo, Yan Li, Guizhong Liu, Xiaohong She, Zhengxi Dai
Filed: 23 Dec 20
Utility
Compositions and Methods for Treating Cancer
4 May 23
The present application provides compositions and methods for treating cancers, including follicular lymphoma, T cell lymphoma and adenoid cystic carcinoma, using an anti-CD137 antibody that specifically binds to an extracellular domain of human CD137.
Peter Peizhi LUO, Guizhong LIU, Changhua GONG
Filed: 13 May 21
Utility
Heterodimeric Proteins with FC Mutations
20 Apr 23
Provided are heterodimeric proteins comprising polypeptides having CH3 domains with engineered residues that form disulfide bonds and/or salt bridges.
Peter Peizhi LUO, Fangyong DU, Guizhong LIU, Zhengxi DAI, Jianfeng SHI, Zhixiong LIN, Yan LI
Filed: 22 Jan 21
Utility
ANTI-CD137 Molecules and Use Thereof
30 Jun 22
The present disclosure provides antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, and for the treatment of cancer.
Peter Peizhi LUO, Fangyong DU, Yan LI, Guizhong LIU, Jun CHEN, Xiaohong SHE, Peter CHEUNG
Filed: 28 Dec 21
Utility
Integrated System for Library Construction, Affinity Binder Screening and Expression Thereof
24 Mar 22
A recombinant polynucleotide suitable for use in a display vector is provided.
Fangyong DU, Peter Peizhi LUO
Filed: 1 Dec 21
Utility
ANTI-CTLA4 Antibodies and Methods of Making and Using the Same
8 Jul 21
Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).
Peter Peizhi LUO, Fangyong DU, Zhongzong PAN, Guizhong LIU
Filed: 2 Feb 19
Utility
Activatable Antibodies and Methods of Making and Using Thereof
8 Jul 21
Provided herein are libraries containing synthetic polynucleotides that encode activatable binding polypeptides.
Peter Peizhi LUO, Fangyong DU
Filed: 2 Feb 19
Utility
ANTI-PD-L1 Antibodies and Use Thereof
29 Apr 21
The present disclosure provides antibodies that bind to the T-cell co-inhibitor ligand programmed death-ligand1 (PD-L1) protein, and methods of use.
Peizhi Luo, Fangyong Du, Guizhong Liu, Yan Li
Filed: 29 Mar 19
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