7 patents
Utility
Method for treating cancer using anti-CD137 antibody
2 Jan 24
Provided are antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, and for the treatment of cancer.
Peter Peizhi Luo, Fangyong Du, Guizhong Liu, Yan Li, Jun Chen, Xiaohong She, Peter Cheung
Filed: 21 Aug 18
Utility
Anti-CTLA4 antibodies and methods of making and using the same
4 Jul 23
Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).
Peter Peizhi Luo, Fangyong Du, Zhongzong Pan, Guizhong Liu
Filed: 2 Feb 19
Utility
Dynamic human antibody light chain libraries
21 Feb 23
Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody light chain with specific hypervariable regions HVR-L1, HVR-L2, and HVR-L3.
Peter Peizhi Luo, Yan Li, Fangyong Du
Filed: 21 Aug 17
Utility
Dynamic human heavy chain antibody libraries
14 Feb 23
Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2.
Peter Peizhi Luo, Yan Li, Fangyong Du
Filed: 21 Aug 17
Utility
Methods and systems for autoinduction of protein expression
1 Nov 22
Methods and systems for autoinduction of gene expression, without the need to add exogenous inducers.
Fangyong Du, Peter Peizhi Luo
Filed: 19 Dec 14
Utility
Anti-CTLA4 antibodies and methods of making and using the same
14 Jun 22
Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).
Peter Peizhi Luo, Fangyong Du, Zhongzong Pan, Guizhong Liu
Filed: 1 Feb 19
Utility
Anti-CD137 molecules and use thereof
8 Feb 22
The present disclosure provides antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, and for the treatment of cancer.
Peter Peizhi Luo, Fangyong Du, Yan Li, Guizhong Liu, Jun Chen, Xiaohong She, Peter Cheung
Filed: 21 Aug 18
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