67 patents
Utility
Wearable Assistance Devices and Methods of Operation
18 Jan 24
Wearable assistance devices and methods of operating the same are provided.
Karl Zelik, Matthew Yandell, Dustin Howser, Erik Lamers
Filed: 27 Sep 23
Utility
Large-scale Epigenomic Reprogramming Links Anabolic Glucose Metabolism to Distant Metastasis During the Evolution of Pancreatic Cancer Progression
11 Jan 24
The present invention relates to a method of identifying epigenetic reprogramming.
Oliver McDonald, Xin Li, Christine A. Iacobuzio-Donahue, Andrew P. Feinberg
Filed: 1 Aug 23
Utility
Antagonists of the Muscarinic Acetylcholine Receptor M4
11 Jan 24
Aaron M. Bender, Matthew Spock, Melissa A. Korkmaz-Vaisys, Craig W. Lindsley, P. Jeffrey Conn
Filed: 18 Nov 21
Utility
Valveless Devices for Pulsatile Fluid Flow
11 Jan 24
Described are pumps structured for moving fluids with pulsatile flow.
Marvin J. Slepian, Eric J. Barth, Mengtang Li
Filed: 12 Aug 21
Utility
Compounds and Methods for Scavenging Dicarbonyl Electrophiles
4 Jan 24
Keith T. Wilson, John A. Oates, Olivier Boutaud, Venkataraman Amarnath, Erica J. Carrier, Alain P. Gobert
Filed: 10 Jul 23
Utility
Compositions and Methods for Targeting the Interaction of Host MYO5B+D and Coronavirus M Proteins
4 Jan 24
Disclosed herein is a method for treating or preventing a coronavirus infection in a subject that involves administering to the subject an effective amount of a composition comprising an agent that disrupts the binding of coronavirus membrane glycoprotein (M protein) and Myosin Vb protein (MYO5B).
Frédéric TANGY, Pierre-Olivier VIDALAIN, James R. GOLDENRING, Joseph T. Roland, Lynne A. LAPIERRE, Elizabeth MANNING, Cornelis Alexander Maria DE HAAN
Filed: 3 Nov 21
Utility
Multi-articulated Catheters with Safety Methods and Systems for Image-guided Collaborative Intravascular Deployment
21 Dec 23
Systems and method for controlling the bending of a robotic catheter.
Nabil Simaan, Giuseppe Del Giudice, Colette Abah, Rohan V. Chitale
Filed: 7 Mar 23
Utility
Therapeutic Window for Citrulline Therapy
21 Dec 23
This invention is directed to citrulline therapy, where citrulline is administered to achieve a newly recognized therapeutic window.
Gurdyal Kalsi, Marshall Summar, Frederick E. Barr, Omar Ayyub, Gary R. Pasternack
Filed: 21 Jun 22
Utility
SIMULTANEOUS FOCUSED ULTRASOUND AND fMRI AND APPLICATION OF FOCUSED ULTRASOUND OUTSIDE OF MRI ENVIRONMENT
14 Dec 23
A workflow has been developed that enables initially mapping of a focused ultrasound (FUS) beam using magnetic resonance (MR) thermometry or MR-acoustic radiation force imaging (MR-ARFI) while working within the MRI device.
Charles F. Caskey, Limin Chen, William A. Grissom, Peter E. Konrad, Benoit M. Dawant, Willliam J. Rodriguez
Filed: 8 Oct 21
Utility
Rigid Phantom for End-to-end Verification of Adaptive Radiotherapy Systems
14 Dec 23
Systems and methods associated with a phantom assembly are provided.
Adam D. YOCK, Abby E. DARE, Michael Price
Filed: 28 Aug 23
Utility
L-dna Encrypted Tracers
7 Dec 23
The present disclosure is directed to the use of left-handed DNA (L-DNA) tracer to identify the source, track the distribution, and validate the integrity of products or resources that are highly regulated, valuable, or hazardous (e.g., pharmaceuticals, treated water, chemicals, designer products, and ammunitions).
Nicholas M. ADAMS, Frederick R. HASELTON
Filed: 26 May 23
Utility
Ifetroban Treatment for Systemic Sclerosis
30 Nov 23
The present invention is directed to methods of treating, preventing, and/or ameliorating systemic sclerosis, by administration of a therapeutically effective amount of ifetroban or a pharmaceutically acceptable salt thereof.
Leo PAVLIV, James West, Ines Macias-Perez, Erica Carrier
Filed: 10 Aug 23
Utility
Automated Methods and Systems for Retrieving Information from Scanned Documents
30 Nov 23
Automated systems and methods for retrieving information from scanned documents are described herein.
Michael Ward, Dax Westerman, Ruth Reeves, Jesse Wrenn
Filed: 31 May 23
Utility
Side Viewing Endoscopic Endcap
23 Nov 23
A system includes an endcap configured to be fitted on a distal end of an endoscope having a forward-looking camera and a forward-facing working port.
Joshua GAFFORD, Robert J. WEBSTER, III, Patrick L. ANDERSON, Scott WEBSTER
Filed: 5 Oct 21
Utility
Treating Primary or Idiopathic Hyperoxaluria with Small Molecule Inhibitors of Lactate Dehydrogenase
23 Nov 23
Matthew HALL, Daniel J. URBAN, John KNIGHT, Ross HOLMES, Kyle David WOOD, Alex WATERSON, Victor M. DARLEY-USMAR, Leonard M. NECKERS
Filed: 14 Jul 23
Utility
REPAIRED THERAPEUTIC AND PROPHYLACTIC ANTIBODIES AGAINST SARS-CoV-2 VARIANTS
16 Nov 23
Provided herein are novel monoclonal antibodies and antibody fragments with improved binding to and/or neutralization against multiple SARS-CoV-2 variants, e.g., Omicron lineages.
Edmond Y. Lau, Daniel M. Faissol, Thomas Anthony Desautels, Fangqiang Zhu, Adam T. Zemla, Robert Herschel Carnahan, JR., Antonietta Maria Lillo, James E. Crowe, JR., Kathryn Arrildt
Filed: 16 Mar 23
Utility
Surgical Device Tip with Deflectable Joint
16 Nov 23
A small diameter surgical tool implements an agonist-antagonist deflectable joint.
Katherine E. Riojas, Robert J. Webster, Daniel Caleb Rucker, Kaitlin Oliver Butler, Ryan Ponten
Filed: 25 Jul 23
Utility
Use of 2-HOBA to Treat Atherosclerosis
16 Nov 23
A method of treating familial hypercholesterolemia accelerated atherosclerosis in a subject in need thereof, comprising administering an effective amount of a dicarbonyl scavenger.
MacRae F. Linton, Sean S. Davies, Olivier Boutaud
Filed: 1 Jun 21
Utility
Method of Preventing Kidney Injury Disruption of Intestinal Lymphatics
9 Nov 23
A method of treating proteinuric kidney injury, comprising administering an effective isoLG scavenging amount of at least one compound of the present invention.
Valentina Kon, Naji Abumrad, Sean Davies, Haichun Yang
Filed: 13 Apr 23
Utility
Positive Allosteric Modulators of the Muscarinic Acetylcholine Receptor M4
2 Nov 23
Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4).
Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Sean Bollinger, James C. Tarr, Paul Spearing, Julie L. Engers, Madeline Long, Thomas M. Bridges
Filed: 29 Jun 23