933 patents
Page 14 of 47
Utility
Methods for Treating Metastatic Triple Negative Breast Cancer with ANTI-PD-1 Antibodies
1 Dec 22
The present invention relates to methods for treating metastatic triple negative breast cancer in a human patient which has been identified as having a PD-L1 enriched tumor comprising administering, as monotherapy, an anti-PD-1 antibody or antigen binding fragment thereof (e.g., pembrolizumab) in specific amounts to the patient about every three or six weeks, wherein the PD-L1 enriched tumor is a tumor identified as having a CPS score of ≥10.
Gursel Aktan, Roger Delemere Dansey, Vassiliki Karantza, Zifang Guo, Jaime A. Mejia, Shu-Chih Su, Jing Zhao, Xuan Zhou
Filed: 23 Sep 20
Utility
a Novel Vaccine Against Heamophilus Parasuis
1 Dec 22
The invention pertains to a protein having at least 69% sequence identity with the protein according to SEQ ID No: 1 or an immunogenic fragment of this protein, for use in a prophylactic method to protect a pig against an infection with Haemophilus parasuis serotype 4 and an infection with Haemophilus parasuis serotype 5, by administering a vaccine to the pig, the vaccine comprising the protein or the immunogenic fragment thereof as an antigen.
Antonius Arnoldus Christiaan Jacobs, Theodora Johanna Van Kasteren-Westerneng, Johanna Jacoba Elisabeth Bijlsma
Filed: 19 Nov 20
Utility
Compounds for Reducing the Viscosity of Biological Formulations
1 Dec 22
Lin Chu, Nathalie Y. Toussaint, Dong Xiao, Petr Vachal, Ramesh S. Kashi, Annette Bak
Filed: 29 Jun 22
Utility
Well Plate Assembly with Interior Channel System
1 Dec 22
A well plate assembly with an interior channel system in the well plate lid provides a more efficient and uniform distribution of fluid into a receptacle positioned below the well plate lid.
Tinh Nguyen-DeMary, William James Ciolino
Filed: 14 Jul 22
Utility
Cycloalkyl 3-OXOPIPERAZINE Carboxamides and Cycloheteroalkyl 3-OXOPIPERAZINE Carboxamides As NAV1.8 Inhibitors
1 Dec 22
Ashok Arasappan, Ian M. Bell, Jason M. Cox, Michael J. Kelly, III, Mark Eric Layton, Hong Liu, Jian Liu, Akshay A. Shah, Michael D. VanHeyst
Filed: 5 May 22
Utility
ANGIOGENESIS AND mMDSC GENE EXPRESSION BASED BIOMARKER OF TUMOR RESPONSE TO PD-1 ANTAGONISTS
1 Dec 22
The invention relates to (i) an angiogenesis gene signature and (ii) a monocytic myeloid-derived suppressor cell (mMDSC) gene signature that are each predictive of patient response to treatment with a PD-1 antagonist, wherein the angiogenesis signature comprises five or more genes.
Mark D. Ayers, Razvan Cristescu, Andrey Loboda, Jared K. Lunceford, Hua Ma, Terrill K. McClanahan, Michael Nebozhyn, Chunsheng Zhang
Filed: 29 Oct 20
Utility
Antibody drug conjugate for anti-inflammatory applications
29 Nov 22
Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.
Philip E. Brandish, Robert M. Garbaccio, Jeffrey Kern, Linda Liang, Sanjiv Shah, Dennis Zaller, Andrew Beck, Dennis Gately, Nick Knudsen, Anthony Manibusan, Jianing Wang, Ying Sun
Filed: 30 Sep 16
Utility
Anti-coagulation factor XI antibodies
29 Nov 22
Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Bianka Prinz
Filed: 1 May 20
Utility
In silico process for selecting protein formulation excipients
29 Nov 22
The invention relates to an in silico screening method to identify candidate excipients for reducing aggregation of a protein in a formulation.
Francis Insaidoo, David Roush
Filed: 6 Mar 17
Utility
Cyclic polypeptides for PCSK9 inhibition
22 Nov 22
Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds.
Alonso Ricardo, Thomas Joseph Tucker, Nicolas Cedric Boyer, Ketki Ashok Dhamnaskar, Zhong Ma, Angela Dawn Kerekes, Chengwei Wu, Sookhee Nicole Ha, Hyewon Youm, Elisabetta Bianchi, Danila Branca, Raffaele Ingenito, Willy Costantini, Aurash Shahripour, Yusheng Xiong
Filed: 20 Jun 19
Utility
Drug Delivery System for the Delivery of Antiviral Agents
17 Nov 22
This invention relates to novel implant drug delivery systems for long-acting delivery of antiviral drugs.
Seth P. Forster, Stephanie Elizabeth Barrett, Ryan S. Teller, Morgan B. Giles, Athanas Koynov
Filed: 11 Aug 20
Utility
PRMT5 Inhibitors
17 Nov 22
Michelle Machacek, David Witter, Craig Gibeau, Chunhui Huang, Shuhei Kawamura, David L. Sloman, Phieng Siliphaivanh, Ryan Quiroz, Murray Wan, Sebastian Schneider, Charles S. Yeung, Michael H. Reutershan, Timothy J. Henderson, Jean-Laurent Paparin, Houcine Rahali, Jonathan M. E. Hughes, Sulagna Sanyal, Yingchun Ye, David A. Candito, Patrick S. Fier, Steven M. Silverman
Filed: 5 Aug 19
Utility
Aryl Sulfonamides As BLT1 Antagonists
17 Nov 22
Yongxin Han, Jongwon Lim, Satyanarayana Tummanapalli, Phieng Siliphaivanh, Kerrie Spencer
Filed: 10 Jun 21
Utility
P116 Antibodies
17 Nov 22
The present invention provides antibodies and antigen-binding fragments thereof that bind PI16 and block binding of ILT3 to PI16.
Daniel Cua, Holly Cherwinski, Adele Wang, Yi Chen, Barbara Joyce-Shaikh
Filed: 16 May 22
Utility
Substituted imidazo[1,2-c]quinazolines as A2A antagonists
15 Nov 22
Yeon-Hee Lim, Gioconda V. Gallo-Etienne, Joseph Michael Kelly, Michael Berlin, Pauline Ting, Hongwu Wang
Filed: 10 Dec 18
Utility
Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
15 Nov 22
Yongxin Han, Abdelghani Achab, Indu Bharathan, Xavier Fradera, Derun Li, Nunzio Sciammetta, Wensheng Yu
Filed: 9 Nov 18
Utility
Inhibitors of Hepatitis C Virus Replication
10 Nov 22
Craig A. Coburn, Steven W. Ludmerer, Kun Liu, Hao Wu, Richard Soll, Bin Zhong, Jian Zhu
Filed: 19 May 21
Utility
Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
8 Nov 22
The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR.
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui, Julie Marie Skinner
Filed: 4 Sep 18
Utility
Long-acting co-agonists of the glucagon and GLP-1 receptors
8 Nov 22
Long-acting co-agonists of the glucagon and GLP-1 receptors are described.
Anandan Palani, Ravi Nargund, Paul E. Carrington, Tomi Sawyer, Qiaolin Deng, Antonello Pessi, Elisabetta Bianchi, Federica Orvieto
Filed: 26 Aug 20
Utility
Automated Parasite Analysis System
3 Nov 22
A parasite analysis system includes a pressure vessel configured to store a biological sample, an imaging cell connected to the pressure vessel, and a waste depository connected to the imaging cell.
Pavel Vácha, Petr Jankuj, Richard Josef Marhoefer, Václav Belák, Jindrich Soukup, Brunhilde Schölzke, Britta von Oepen
Filed: 18 Jul 22