933 patents
Page 16 of 47
Utility
MDBK IRF3/IRF7 Knock Out Mutant Cell and Its Use for Vaccine Production
6 Oct 22
The present invention pertains to a Madin-Darby bovine kidney (MDBK) cell, wherein the interferon regulatory factors (IRF) IRF3 and/or IRF7 encoding genes are functionally inactivated.
Alexander Martijin Langereis, Ad De Groof, Willem Bartjan Simmelink, Paul Vermeij
Filed: 5 Jun 20
Utility
Hydroxypyrrolidine-substituted Arylsulfonamide Compounds with Selective Activity In Voltage-gated Sodium Channels
29 Sep 22
Anthony J. Roecker, Mark E. Layton, Deping Wang, Xiu Wang, Xuanjia Peng
Filed: 8 Jun 20
Utility
Pro Drugs of PDE10 Compounds
29 Sep 22
The present invention is directed to pro drugs of 2-methyl-N-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-6-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-4-amine which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10).
Sachin Mittal, Jason W. Skudlarek, Izzat T. Raheem
Filed: 15 Mar 22
Utility
System And Method For Determning Status Of Health Of Animals Arriving At A Feed Location
29 Sep 22
A system and method are provided for screening and treating respiratory diseased animals such as livestock.
Robert S. SCHELLER, Jason NICKELL, Akshaya NATARAJ
Filed: 3 Aug 20
Utility
Pharmaceutical compositions of tedizolid phosphate
27 Sep 22
Disclosed are pharmaceutical compositions comprising tedizolid phosphate, methods of preparing such pharmaceutical compositions, and methods of treating bacterial infections with such pharmaceutical compositions.
Lixia Cai, David Dubost, David Harris, Yongjun Li, Majid Mahjour, Dan Zhang
Filed: 10 Dec 18
Utility
Cyclic di-nucleotide compounds as sting agonists
27 Sep 22
Michael D. Altman, Brian Andresen, Wonsuk Chang, Jared N. Cumming, Ryan D. Otte, Benjamin Wesley Trotter
Filed: 18 Jun 20
Utility
Injectable Pharmaceutical Compositions and Uses Thereof
22 Sep 22
Brenda L. Valle Colon, Keith A. Freehauf, Frank Guerino, Christopher D. Kulczar, Brian Carrillo
Filed: 1 May 20
Utility
Compositions Comprising Streptococcus Pneumoniae Polysaccharide-protein Conjugates and Methods of Use Thereof
22 Sep 22
The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein.
Chitrananda Abeygunawardana, Yadong Adam Cui, Romulo Ferrero, Jian He, Luwy Musey, Tanaz Petigara, Julie M. Skinner
Filed: 17 Dec 19
Utility
Processes for the Formulation of Pneumococcal Polysaccharides for Conjugation to a Carrier Protein
22 Sep 22
The present invention provides a number of process improvements related to the conjugation of capsular polysaccharides from Streptococcus pneumoniae to a carrier protein.
Patrick McHugh, Michael Albert Winters, Janelle Konietzko
Filed: 9 Jun 22
Utility
Variable, multi-dose microtablet dispenser
20 Sep 22
A microtablet dispenser is provided herein including: a microtablet reservoir disc including a plurality of wells each formed to accommodate at least one microtablet, the wells being arranged in at least one array; a screen plate having at least one opening shaped to expose all of the wells of one of the arrays when aligned therewith; and, a dose selector plate including a plurality of dosing apertures arranged in a plurality of dosing arrays of different patterns.
Annaniy Berenshteyn, Mikhail Gotliboym, Christopher Granelli
Filed: 5 Feb 20
Utility
Devices and methods for nerve stimulation
20 Sep 22
A system for nerve stimulation is provided; it comprises a nerve stimulation device configured to execute a set of nerve stimulation instructions for generating electrical pulses for nerve stimulation of a patient.
Gianluca Gigante
Filed: 11 Mar 19
Utility
PD-L1 antibodies binding canine PD-L1
20 Sep 22
The present disclosure describes antibodies including caninized antibodies against canine PD-L1 with specific properties.
Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
Filed: 18 Dec 19
Utility
2-AMINO-N-HETEROARYL-NICOTINAMIDES As NAV1.8 Inhibitors
15 Sep 22
Ashok Arasappan, Ian M. Bell, Michael J. Breslin, Christopher James Bungard, Christopher S. Burgey, Harry R. Chobanian, Jason M. Cox, Anthony T. Ginnetti, Deodial Guy Guiadeen, Kristen L.G. Jones, Mark E. Layton, Hong Liu, Jian Liu, James J. Perkins, Shawn J. Stachel, Linda M. Suen-Lai, Zhe Wu
Filed: 24 May 22
Utility
Antigenic Glycoprotein E Polypeptides, Compositions, and Methods of Use Thereof
8 Sep 22
The disclosure relates to HSV glycoprotein E antigenic peptide constructs and HSV protein vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
Arthur Fridman, Jennifer Dawn Galli, Dai Wang, Lan Zhang
Filed: 14 Jul 20
Utility
Natriuretic Peptide Receptor a Agonists Useful for the Treatment of Cardiometabolic Diseases, Kidney Disease and Diabetes
8 Sep 22
Frank Bennett, Jason E. Imbriglio, Angela D. Kerekes, Tanweer Khan, Claire Lankin, Derun Li, Zhicai Wu, Yusheng Xiong, Hyewon Youm, Yang Yu, Feng Ye, Anthappan Tony Kurissery, Venukrishnan Komanduri
Filed: 18 May 20
Utility
Chromane monobactam compounds for the treatment of bacterial infections
6 Sep 22
Tesfaye Biftu, Xianhai Huang, Weiguo Liu, Weidong Pan, Min Park, Alexander Pasternak, Wanying Sun, Haifeng Tang, Yi Zang
Filed: 27 Sep 18
Utility
Glucose-responsive Insulin Conjugates
1 Sep 22
Glucose-responsive insulin conjugates that contain one or more trisaccharides are provided.
Danqing Feng, Erin N. Guidry, Pei Huo, Andrew J. Kassick, Ahmet Kekec, Songnian Lin, Christopher R. Moyes, Dmitri A. Pissarnitski, Lin Yan, Yuping Zhu
Filed: 23 Jul 20
Utility
Natriuretic Peptide Receptor a Agonists Useful for the Treatment of Cardiometabolic Diseases, Kidney Disease and Diabetes
1 Sep 22
Qingmei Hong, Jason E. Imbriglio, Angela D. Kerekes, Tanweer Khan, Claire Lankin, Derun Li, Rui Liang, Pengcheng Patrick Shao, Zhicai Wu, Yusheng Xiong, Feng Ye, Hyewon Youm, Yang Yu, Anthappan Tony Kurissery, Venukrishnan Komanduri
Filed: 18 May 20
Utility
Well plate assembly with pressure release mechanism
30 Aug 22
A well plate assembly with an interior channel system in the well plate lid provides a more efficient and uniform distribution of fluid into a receptacle positioned below the well plate lid.
Tinh Nguyen-DeMary, William James Ciolino
Filed: 24 Feb 20
Utility
PCSK9 antagonist compounds
30 Aug 22
Harold B. Wood, Hubert B. Josien, Thomas Joseph Tucker, Angela Dawn Kerekes, Ling Tong, Abbas M. Walji, Anilkumar G. Nair, Fa-Xiang Ding, Elisabetta Bianchi, Danila Branca, Chengwei Wu, Yusheng Xiong, Sookhee Nicole Ha, Jian Liu, Sobhana Babu Boga
Filed: 20 Jun 19