933 patents
Page 3 of 47
Utility
Macrocyclic Urea Orexin Receptor Agonists
7 Dec 23
The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors.
Kira A. Armacost, Maria Irina Chiriac, Danielle M. Hurzy, Jeffrey C. Kern, Jian Liu, Peter J. Manley, Vanessa L. Rada, Michael T. Rudd, Craig A. Stump, Zhe Wu, Dong Xiao
Filed: 28 Oct 21
Utility
Caninized Antibodies to Canine INTERLEUKIN-31 Receptor Alpha
7 Dec 23
The present invention provides caninized rat antibodies to canine IL-31 receptor alpha that have a high binding affinity for canine IL-31 receptor alpha, and that can block the binding of canine IL-31 to canine IL-31 receptor alpha.
Mohamad Morsey, Yuanzheng Zhang, Anasuya Saha
Filed: 14 Oct 21
Utility
Modified Benzofuran-carboxamides As Glucosylceramide Synthase Inhibitors
7 Dec 23
Michael J. Breslin, Mark E. Fraley, Melissa C. Ford, Kristen L.G. Jones, SR., Anthony J. Roecker, Kathy M. Schirripa, Ling Tong
Filed: 15 Sep 21
Utility
Animal tag
5 Dec 23
an animal tag comprising: a one-piece animal tag retaining member made of molded material, having: a first part comprising a female opening connectable to a male member for coupling the animal tag to a body part of an animal; a second part configured to accommodate one or more electronical components capable of obtaining information relating to the animal to which the animal tag is coupled; an intermediate part, located between the first tag part and the second tag part, having a form of a latitudinal recess for enhancing a flexibility of the animal tag.
Mordehay Cohen, Taras Khomitsky, Samy Hazan
Filed: 13 May 21
Utility
Lung Cancer Combination Therapy with IL-2 Conjugates and an ANTI-PD-1 Antibody or Antigen-binding Fragment Thereof
30 Nov 23
Disclosed herein are methods for treating a lung cancer in a subject in need thereof, comprising administering IL-2 conjugates in combination with the anti-PD-1 antibody or antigen-binding fragment thereof (e.g., pembrolizumab).
Giovanni Abbadessa, Carolina E. Caffaro, Brigitte Demers, Joseph Leveque, Wan-Ju Meng, Jerod Ptacin
Filed: 10 Aug 23
Utility
System for external fish parasite monitoring in aquaculture
28 Nov 23
A system for external fish parasites monitoring in aquaculture, the system comprising: —a camera (52) suitable to be submerged in a sea pen suitable for containing comprising fish, the camera being arranged for capturing images of the fish; and—an electronic image processing system (86) configured for identifying external fish parasites on the fish by analyzing the captured images, wherein: —a ranging detector (54) configured for detecting the presence of fish and measuring a distance from the detector to the fish is mounted adjacent to the camera (52); and—an electronic control system (12) is arranged to control a focus of the camera (52) on the basis of the measured distance and to trigger the camera (52) when a fish has been detected within a predetermined distance range.
Russel Howe, Zachary Lizer, James Wallace Sarrett, Peter Jon Abrahamson, Jascha Tucker Little
Filed: 19 Dec 18
Utility
Phosphinic amide prodrugs of tenofovir
28 Nov 23
Compounds of Formula I: I and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase.
Manuel De Lera Ruiz, Izzat Raheem, Michael T. Rudd
Filed: 15 Jul 19
Utility
Human interleukin-2 conjugates biased for the interleukin-2 receptor beta GAMMAc dimer and conjugated to a nonpeptidic, water-soluble polymer
28 Nov 23
Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor βγc dimer over binding the IL-2 receptor αβγc trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described.
Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
Filed: 20 Apr 21
Utility
Synthetic pathway to belzutifan and crystalline phases of synthetic intermediates
28 Nov 23
Stephen M. Dalby, Clinton Scott Shultz, Chintal Desai, Joshua Lee, Zhiwei Chen, Jungchul Kim, Nastaran Salehi Marzijarani, Tao Wang, Eric M. Phillips, Patrick Larpent, Het P. Patel, Haiheng Guo, Xin Wang, Kangze Dai, Lu Chen, Teng Li, Taotao Lu, Jianjun Duan
Filed: 20 May 22
Utility
Conjugate based systems for controlled insulin delivery
21 Nov 23
The present disclosure provides conjugates that comprise an insulin molecule conjugated via a conjugate framework to two or more separate ligands that each include a saccharide, wherein the framework, ligand, saccharide and insulin molecule optionally comprise a fatty chain (e.g., a C8-30 fatty chain), wherein when said insulin molecule is conjugated both to a C8-30 fatty chain and one or more separate ligands that each include a saccharide, said C8-30 fatty chain is linked to insulin molecule only, and wherein when the framework or ligand comprises a fatty chain the insulin molecule is conjugated to two or more separate ligands.
Lin Yan, Pei Huo, Ahmet Kekec, Danqing D. Feng, Yuping Zhu, Dmitri Pissarnitski, Chris Moyes, Songnian Lin
Filed: 13 Dec 18
Utility
Method for Automatic Sea Lice Monitoring In Salmon Aquaculture
16 Nov 23
The present invention pertains to a method for automatic sea lice monitoring in fish aquaculture, the method comprising submerging a camera (4) in a sea pen (300) comprising fish, using the camera to make an image of at least one of said fish, analysing the image to differentiate between individual sea lice present on the fish and the fish itself and assessing the number of sea lice present on the fish, wherein the camera is attached to a device (1, 10, 100) for guiding the salmon along an imaging track (5), the camera being directed to the track.
Peter Jans, Evert Gijtenbeek
Filed: 19 Apr 23
Utility
Binding Proteins and Antigen Binding Fragments Thereof That Bind Abeta
16 Nov 23
Binding proteins that bind amyloid beta (Abeta) are described, including heavy chain antibody variable domain (VHH) constructs comprising human-like VHH comprising three synthetically generated complementarity determining region (CDR) areas.
Alexander Mario Sevy, Ming-Tang Chen
Filed: 27 Sep 21
Utility
Inhibitors of Human Respiratory Syncytial Virus and Metapneumovirus
16 Nov 23
Douglas C. Beshore, Brett R. Ambler, Kira A. Armacost, Christopher James Bungard, Danielle M. Hurzy, Peter J. Manley, Kelly-Ann S. Schlegel, Linda M. Suen-Lai, Mahdieh Yazdani
Filed: 11 May 23
Utility
Bicycloheptane Pyrrolidine Orexin Receptor Agonists
16 Nov 23
Stephane L. Bogen, Dane James Clausen, Deodial Guy Guiadeen, Jinsong Hao, Shishi Lin, Michael T. Rudd, Lan Wei, Li Xiao, Dexi Yang
Filed: 16 Aug 21
Utility
Inhibitors of Human Respiratory Syncytial Virus and Metapneumo Virus
16 Nov 23
Douglas C. Beshore, Brett R. Ambler, Kira A. Armacost, Christopher James Bungard, Danielle M. Hurzy, Peter J. Manley, Kelly Ann S. Schlegel, Linda M. Suen-Lai, Mahdieh Yazdani
Filed: 11 May 23
Utility
Dosing Regimens of ANTI-ILT4 Antibody or Its Combination with ANTI-PD-1 Antibody for Treating Cancer
16 Nov 23
Provided herein are dosing regimens of an anti-immunoglobulin-like transcript 4 (anti-ILT4) antibody for treating cancer.
Anson K. Abraham, Rachel A. Altura, Douglas C. Wilson
Filed: 15 Sep 21
Utility
Stable Formulations of Programmed Death Receptor 1 (PD-1) Antibodies and Hyaluronidase Variants and Fragments Thereof and Methods of Use Thereof
16 Nov 23
The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof and a PH20 variant or fragment thereof.
Yogita KRISHNAMACHARI, Sachin MITTAL, Sahil S. SANGANI, William P. FORREST, Jr., Yongchao SU, Xi ZHAO, Katelyn Jean SMITH
Filed: 23 Sep 21
Utility
Azide Insulin Analogues
16 Nov 23
The present invention relates to insulin analogues and processes of making such insulin analogues by direct conversion of a free amine to an azide via diazo-transfer with an azotransfer agent.
Sobhana Babu Boga, Ahmet Kekec, Songnian Lin, Craig A. Parish, Weijuan Tang, Lin Yan
Filed: 31 Jul 23
Utility
Methods of Chemovaccination Against Plasmodium Infections
9 Nov 23
A method of chemovaccination against Plasmodium infections comprising administering to a patient, an effective amount of a dual inhibitor of plasmepsin IX and X, or a pharmaceutically acceptable salt thereof.
Justin A. Boddey, David B. Olsen, Ryan Steel
Filed: 20 Sep 21
Utility
Feline Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine
9 Nov 23
The present invention provides new vaccines for felines and ferrets to aid in reducing shedding of severe acute respiratory syndrome coronavirus 2 by infected felines or ferrets.
Mark A. Mogler, Ian Tarpey
Filed: 10 May 21