933 patents
Page 5 of 47
Utility
2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES As NAV1.8 Inhibitors
5 Oct 23
Ashok Arasappan, Ian M. Bell, Christopher James Bungard, Christopher S. Burgey, Jason M. Cox, Michael J. Kelly, III, Mark E. Layton, Hong Liu, Jian Liu, James J. Perkins, Akshay A. Shah, Michael David VanHeyst, Zhe Wu
Filed: 5 Jun 23
Utility
Process for Preparing Sugammadex
5 Oct 23
The present invention relates to a process for drying crystalline sugammadex to meet solvent specifications that is independent of API crystallinity or crystalline form generated.
David J. Lamberto, Paolo Avalle, Lorenzo Codan, Patrick Larpent, Jochen Schoell, Jeffrey S. Neuhaus
Filed: 8 Sep 21
Utility
Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
3 Oct 23
Described are antibody peptide conjugates (APCs) comprising an antibody conjugated to a peptide analog of glucagon, which have been modified to be resistant to cleavage and inactivation by dipeptidyl peptidase IV (DPP-IV) and to increase in vivo half-life of the peptide analog while enabling the peptide analog to have agonist activity at the glucagon (GCG) receptor and the glucagon-like peptide 1 (GLP-1) receptor and the use of such APCs for treatment of metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
Paul E. Carrington, Grigori Ermakov, Robert M. Garbaccio, Wolfgang Seghezzi, Elisabetta Bianchi, Federica Orvieto, Dennis Gately, Nick Knudsen, Anthony Manibusan
Filed: 27 Aug 20
Utility
Progressively-trained scale-invariant and boundary-aware deep neural network for the automatic 3D segmentation of lung lesions
3 Oct 23
A system and method are disclosed for segmenting a set of two-dimensional CT slices corresponding to a lesion.
Antong Chen, Gregory Goldmacher, Bo Zhou
Filed: 18 Jan 22
Utility
2-AMINOQUINAZOLINES As LRRK2 Inhibitors, Pharmaceutical Compositions, and Uses Thereof
28 Sep 23
John J. Acton, III, Ryan Chau, Peter H. Fuller, Anmol Gulati, Rebecca Elizabeth Johnson, Solomon Kattar, Mitchell H. Keylor, Derun Li, Kaila A. Margrey, Gregori J. Morriello, Xin Yan
Filed: 1 Sep 21
Utility
Cyclic Polypeptides for PCSK9 Inhibition
28 Sep 23
Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds.
Alonso Ricardo, Thomas Joseph Tucker, Nicolas Cedric Boyer, Joseph R. Stringer, Derek M. LaPlaca, Angela Dawn Kerekes, Chengwei Wu, Sookhee Nicole HA, Hyewon Youm, Mark W. EMBREY, Elisabetta Bianchi, Danila Branca, Raffaele Ingenito, Willy Costantini, Alessia Santoprete, Roberto Costante, Immacolata Conte, Stefania Colarusso, Eric J. GILBERT, Aurash Shahripour, Yusheng Xiong
Filed: 27 Sep 22
Utility
Co-stimulatory 4-1BBL Ectodomain Polypeptides for Immunomodulation
28 Sep 23
The present invention generally relates to the field of immunomodulation and provides various costimulatory polypeptides comprising at least one 4-1BBL ectodomain comprising a (core) minimal TNF Homology Domain.
Jochen STRITZKER, Peter STEINBERGER, Daniela LUPINEK, Annika DE SOUSA LINHARES
Filed: 17 Aug 21
Utility
N3-substituted iminopyrimidinones as antimalarial agents
26 Sep 23
Tanweer A. Khan, Jared N. Cumming, David B. Olsen, Justin A. Boddey, Alan F. Cowman, Brad E. Sleebs
Filed: 13 Feb 17
Utility
Bispecific Caninized Antibodies and Bispecific Binding Partners for Treating Atopic Dermatitis
21 Sep 23
The present invention provides compositions for treating canine atopic dermatitis that comprise a fusion protein that binds canine IL-22, a caninized anti-pruritic antibody, and a caninized anti-inflammatory antibody.
Mohamad Morsey, Yuanzheng Zhang, Anasuya Saha
Filed: 18 Dec 20
Utility
Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
19 Sep 23
The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR.
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Filed: 24 Jun 22
Utility
Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
19 Sep 23
The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR.
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Filed: 24 Jun 22
Utility
Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
19 Sep 23
The present invention provides capsular polysaccharides from Streptococcus pneumoniae serotypes identified using NMR.
Richard J. Porambo, Chitrananda Abeygunawardana, Luwy Kavuka Musey, Michael J. Kosinski, Yadong Adam Cui
Filed: 24 Jun 22
Utility
Anti-coagulation Factor XI Antibodies
14 Sep 23
Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Bianka Prinz, Vaishnavi Ganti, Mohammad Tabrizifard
Filed: 18 Apr 23
Utility
Plasma Kallikrein Inhibitors
14 Sep 23
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion.
Salman Jabri, Anthony Ken Ogawa, Christopher J. Sinz, Jacqueline D. Hicks, Alan C. Cheng, Ying-Duo Gao, Song Yang, Jianming Bao, Donna A. A. W. Hayes, Simon B. Lang, Brandon M. Taoka, Maoqun Tian, Galen Paul Shearn-Nance, Rongze Kuang, Matthew J. Lombardo, Zhicai Wu, Zhiqiang Zhao
Filed: 10 Jun 21
Utility
Synthesis of Fluorinated Nucleotides
14 Sep 23
Cheol Keun Chung, Zhijian Liu, Peter E. Maligres, Edna Mao, Jennifer V. Obligacion, Eric M. Phillips, Michael Pirnot, Marc Poirier, Zhiguo Jake Song, Tao Wang
Filed: 11 Aug 21
Utility
Apparatus and Method of Microwave Vacuum Drying Sterile Products
14 Sep 23
A microwave vacuum dryer includes a loading chamber and a first vacuum pump in communication with the loading chamber, a first door separating the loading chamber from an external environment, a drying chamber adjacent the loading chamber, a second vacuum pump in communication with the drying chamber, and a condenser in communication with the drying chamber, a second door separating the loading chamber and the drying chamber, an unloading chamber adjacent the drying chamber and a third vacuum pump in communication with the unloading chamber, a third door separating the drying chamber from the unloading chamber, a fourth door separating the unloading chamber from the external environment, and a microwave chamber having a plurality of magnetrons, the microwave chamber positioned on a different plane from the loading and unloading chambers and adjacent the drying chamber.
Akhilesh BHAMBHANI, Jeffrey T. BLUE, Robert K. EVANS, Terrence FENNELL, Justin STANBRO
Filed: 1 Jun 21
Utility
Stapled Lactam Co-agonists of the Glucagon and GLP-1 Receptors
14 Sep 23
The stapled peptides of the present invention, and pharmaceutically acceptable salts thereof, are co-agonists of the glucagon and GLP-1 receptors, and may be useful in the treatment, prevention and suppression of diseases mediated by the glucagon receptor and the GLP-1 receptor, including but not limited to, metabolic disorders such as diabetes, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and obesity.
Elisabetta Bianchi, Paul E. Carrington, Qiaolin Deng, Songnian Lin, Federica Orvieto, Anandan Palani, Antonello Pessi, Tomi K. Sawyer
Filed: 18 Dec 20
Utility
Compositions Comprising Streptococcus Pneumoniae Polysaccharide-protein Conjugates and Methods of Use Thereof
7 Sep 23
The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein.
Chitrananda Abeygunawardana, Yadong Adam Cui, Romulo Ferrero, Jian He, Luwy Musey, Tanaz Petigara, Julie M. Skinner
Filed: 23 Mar 23
Utility
Stable Formulations of Cytomegalovirus
7 Sep 23
The present invention relates to stable formulations of a cytomegalovirus (CMV) comprising for example, a genetically modified CMV that is conditionally replication defective, a buffer, alkali or alkaline salt, a sugar, a cellulose derivative and optionally a polyol.
Muneeswara Babu Medi, Harrison Bradford Davis, Lorenzo H. Chen, Lynne Ann Isopi, Jeffrey Thomas Blue, Heidi Joanne Pixley, Erin J. Green-Trexler
Filed: 30 Nov 22
Utility
Syringes and Injectors with Capacitive Sensing and Methods of Making and Using Same
7 Sep 23
An injecting device includes a reservoir for containing a medicament, a needle in communication with the reservoir and configured to deliver the medicament to a patient’s body, at least two electrodes spaced apart from one another and disposed on opposing sides of the needle, and a capacitance-to-digital converter circuit configured to generate a signal and measure capacitance between the at least two electrodes.
Douglas E. Weitzel, Steven Carl Persak, Jeffrey C. Givand, Christopher Granelli
Filed: 15 May 23