1137 patents
Utility
Modular Bio-Processing Unit and a Bio-Processing System Employing Plural Units
18 Jan 24
Disclosed is a modular bio-processing unit comprising: a housing having one or more internal fluid paths, the housing having at least one inlet and at least one outlet, each in fluid communication with the fluid path or one or more of the fluid paths; one or more sensor elements operatively associated with the or each path, said sensor(s) elements including elements of one or more of: a flow sensor, a flow rate sensor, a conductivity sensor, a pressure sensor, a pH sensor, and a light absorbance sensor such as a UV spectroscopic concentration sensor; one or more fluid flow inducing components operatively associated with the or each fluid path; and plural valves for preventing or reducing flow in the or each path, the housing, inlet(s), outlet(s), flow inducing component(s) and valve(s) being arranged to operate together as a bio-processing unit within or substantially within the housing.
Tuomo Valtteri Frigard, Robert Magnusson, Mats Lundkvist, Karl Axel Jakob Liderfelt, Helena Nordvarg, Andreas Torbjorn Lundin, Peter Arne Reffner
Filed: 26 Sep 23
Utility
Bioprocessing Vessel Having Integral Fluid Conduit
18 Jan 24
A bioprocessing apparatus includes a flexible bag having an interior volume configured to contain a fluid, and an integral fluid conduit within the flexible bioprocessing bag.
HANNA-LEENA SAUKKONEN
Filed: 28 Oct 21
Utility
Method of Cleaning and/or Sanitizing a Separation Matrix
18 Jan 24
Annika Forss, Gustav José Rodrigo, Tomas Bjorkman, Mats Ander, Jesper Ulf Hansson
Filed: 18 Jul 23
Utility
Bioprocessing System and Methods
18 Jan 24
A bioprocessing apparatus includes a housing, a process drawer receivable within the housing and moveable between a closed position and an open position, the process drawer being configured to receive at least one culture vessel therein, and a cabinet positioned in stacked vertical relation to the housing, the cabinet including at least one vertical storage drawer slidably received within the cabinet.
MARK TIMMINS, ANDREU FONTOVA SOSA, ROBERT CURTIS, KEITH BENOIT, DONALD FRASER, FERNANDO FRAGA, DENNIS CHEROK, NICOLAS PETITFOURG, ANDREW MALLOY, PHIL RAWLINS
Filed: 14 Dec 21
Utility
Methods for Cell Activation, Transduction and Expansion
18 Jan 24
A method for bioprocessing includes the steps of providing a bioprocessing system having a first bioreactor vessel and a second bioreactor vessel, activating a population of cells in the first bioreactor vessel, genetically modifying the population of cells to produce a population of genetically modified cells, and expanding the population of genetically modified cells within the first bioreactor vessel and the second bioreactor vessel.
PANTELEIMON ZOTOS, YARDEN SIVAN GRATCH, ISABELLE DALLE FUSINE, KASHAN ALI SHAIKH, ALICJA MARIA KROL, NATE W. FREUND, ERWIN V. CAMMAART, ANTHONY P. SWANDA
Filed: 14 Dec 21
Utility
Methods and Apparatus for Scaling In Bioprocess Systems
18 Jan 24
Methods and apparatus for scaling in bioprocess systems are disclosed.
Andreas CASTAN, Nagaraju KONDURU, Ashish HANDA, Neelima BODDAPATI, Helena ÖHRVIK, Alok Singh CHAUHAN
Filed: 29 Sep 21
Utility
In and Relating to Pumps
18 Jan 24
A multiple cavity reciprocating positive displacement pump comprising plural pump cavities each including at least one pair of one-way valves the at least one pair including an inlet valve and an outlet valve, the pump being characterised in that respective inlet valves are in fluid communication with a common inlet and respective outlet valves are in fluid communication with a common outlet.
Andreas Torbjorn Lundin, Klas Marteleur, Mats Lundkvist, Andreas Marcstrom, David Gronowitz
Filed: 12 Sep 23
Utility
Method to Configure a System for Chemical Separation
18 Jan 24
The present invention relates to a method performed by a system (110) operable to configure a chemical separation system (120), the method comprising: receiving system hardware configuration data, wherein the system hardware configuration data is at least indicative of fluid manipulation modules (121_1-12N_M) of the chemical separation system (120), desired functionality of the fluid manipulation modules, and a fluid network (210) comprising fluid couplers configured to fluidly couple the fluid manipulation modules (121_1-12N_M), identifying a first set of function blocks to provide the indicated fluid manipulation modules with the desired functionality, generating a second set of function blocks by purging a third set of function blocks from the first set of function blocks to eliminate dead code using the configuration data, sending the second set of function blocks to the system (120).
Hakan KLANG, Daniel LANDBY, Dave J. Pazzani
Filed: 13 Jul 22
Utility
Method for laser microdissection, laser microdissection system and computer program
16 Jan 24
A method for laser microdissection includes: processing a microscopic examination object by a laser beam using tuples of coordinate values which respectively indicate positions of target points on the examination object at least in a first spatial direction and a second spatial direction orthogonal to the first spatial direction, positions of at least three reference points being ascertained beforehand in each case in the first and second spatial directions and also in a third spatial direction orthogonal to the first and second spatial directions; defining a reference plane based on the positions of the reference points; and determining, for the target points, further coordinate values indicating an expected position of the target points on the examination object in the third spatial direction in each case, as determined further coordinate values, the determining of the further coordinate values being performed depending on the defined reference plane.
Florian Hoffmann, Falk Schlaudraff
Filed: 23 Jan 20
Utility
Method for calibrating a device for measuring the concentration of creatinine
16 Jan 24
A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
Thomas Kjaer, Thomas Pedersen Nyggard
Filed: 14 Dec 15
Utility
Oblique plane microscope for imaging a sample
16 Jan 24
An oblique plane microscope has an objective illuminating a plane of the sample and collecting detection light.
Benjamin Deissler
Filed: 5 Apr 21
Utility
System for Preparing Solutions for Chromatography
11 Jan 24
A system for preparing solutions for chromatography application is disclosed.
Bjorn Markus Olovsson
Filed: 25 Sep 23
Utility
Systems and Methods for Cell Enrichment, Isolation and Formulation
11 Jan 24
An apparatus for magnetic cell isolation includes a base, a stopcock manifold interface located on the base and configured to receive a stopcock manifold of a cell processing kit, a magnetic field generator located within the base, and a slot formed in the base, the slot configured to removably receive a magnetic cell isolation holder.
YORICK HEIMBERG, OLIVIER MARTI, THOMAS MERMOD, BENOIT DUBATH, JULIEN CAMISANI
Filed: 14 Dec 21
Utility
Computer Device for Detecting an Optimal Candidate Compound and Methods Thereof
11 Jan 24
The invention relates to a method for a computer device, for detecting an optimal candidate compound based on a plurality of samples comprising a cell line and one or more biomarkers, and a plate map configuration, wherein the plate map configuration is providing locations of samples comprising cell lines exposed to one or more biomarkers and different concentrations of a candidate compound forming at least one concentration gradient, the candidate compound being comprised in a plurality of candidate compounds, said method comprising generating (310) phenotypic profiles of each concentration gradient of each of the plurality of candidate compounds at a plurality of successive points in time to form a plurality of compound profiles, wherein generating phenotypic profiles comprises the steps obtaining (312) image data depicting each sample comprised in the concentration gradient, generating (314) a class-label and a class for each cell of the samples based on the image data, detecting (320) the optimal candidate compound by evaluating a comparison criterion on the plurality of compound profiles.
Emmanuel Israel Fuentes, Gopal Biligeri Avinash, Robert John Graves, Abhijit Vijay Thatte, Afek Kodesh, Jeffery Caron, Sharmistha Das
Filed: 10 Mar 23
Utility
Connector for aseptic connection, and method for connecting and disconnecting such connectors
9 Jan 24
A connector for forming a substantially aseptic connection is provided, said connector having a connector member a coupling end with a coupling element for engaging a similar coupling element on a similar connector to form a seal.
Klaus Gebauer
Filed: 29 May 19
Utility
Apparatus for Bio-product Processing
4 Jan 24
The present invention relates to an apparatus (200) for bio-product processing.
Stefan K. Eriksson, Andreas Bergstrom, Andreas Sjolund, Gustav D. Andersson, Mikael C. Sjogren
Filed: 17 Nov 21
Utility
System and Methods for Verifying the Integrity of a Bioprocessing System Using Pressurization
4 Jan 24
A method for assessing the integrity of a bioprocessing system includes the steps of utilizing a pump of a bioprocessing system, pressurizing a plurality of flow lines, and measuring a decay of a pressure within the plurality of flow lines for a predetermined a duration.
ANDREU FONTOVA SOSA, KASHAN ALI SHAIKH, PANTELEIMON ZOTOS, MARK TIMMINS
Filed: 14 Dec 21
Utility
Disposable Kits for Cell Washing, Magnetic Isolation and Dosing Preparation
4 Jan 24
A kit for magnetic cell isolation includes first stopcock manifold having at least four stopcocks, a separation chamber configured for use with a centrifugal processing chamber of the cell processing device, the separation chamber in fluid communication with the first stopcock manifold, a mixing bag configured for use with a heating/cooling mixing chamber of a cell processing device, the mixing bag in fluid communication with the first stopcock manifold, a second stopcock manifold having at least four stopcocks, the second stopcock manifold in fluid communication with the first stopcock manifold, a magnetic cell isolation holder in fluid communication with the second stopcock manifold, the magnetic cell isolation holder configured for use with a magnetic field generator of a magnetic cell isolation device, and a plurality of cell processing bags in fluid communication with the first and/or second stopcock manifolds.
PIERRE-YVES CHASSOT, OLIVER LINK, FEDERICO ZANONI, MARK TIMMINS, KASHAN ALI SHAIKH, MARINE DE LAGENESTE, DENNIS CHEROK, YANN THOUEMENT, YORICK HEIMBERG, BERTRAND FOUCAUT, JULIEN CAMISANI, KENT YOUNG, SIMON GARDINER, ANTHONY P. SWANDA
Filed: 14 Dec 21
Utility
a Process Photometer Arrangement
4 Jan 24
Disclosed is a process photometer arrangement (10) with a photometric cuvette unit (20) comprising a cuvette body (24) defining a cuvette cavity (25) and a combined sample inlet/outlet opening (34), a photometer light inlet window (60) and a photometer light outlet window (62).
Andreas Golitz, Markus Hahn, Andreas Jonak, Andreas Schwenk, Sebastian Minke, Markus Lenhard, Bas De Heij, Heinz Rudde, Maik Heuwold, Sven Bergmann
Filed: 28 Oct 21
Utility
Sample Manipulation Device and Method
4 Jan 24
A sample manipulation device includes a manipulation light source configured to emit manipulation light, an objective configured to focus the manipulating light onto the sample to form a manipulation light beam, a scanning unit configured to move the manipulation light beam within a field of view of the objective, a sample positioning unit configured to move the sample relative to an optical axis of the objective, and a controller configured to receive manipulation data comprising at least one manipulation path, upon determining that the manipulation path is entirely outside the predetermined area, control the manipulation light source and the scanning unit such that the sample is manipulated along the manipulation path, and upon determining that at least a part of the manipulation path is inside the predetermined area, control the sample positioning unit to move the sample such that the manipulation path is entirely outside the predetermined area.
Falk SCHLAUDRAFF, Florian HOFFMANN
Filed: 19 Jun 23