450 patents
Utility
Method for laser microdissection, laser microdissection system and computer program
16 Jan 24
A method for laser microdissection includes: processing a microscopic examination object by a laser beam using tuples of coordinate values which respectively indicate positions of target points on the examination object at least in a first spatial direction and a second spatial direction orthogonal to the first spatial direction, positions of at least three reference points being ascertained beforehand in each case in the first and second spatial directions and also in a third spatial direction orthogonal to the first and second spatial directions; defining a reference plane based on the positions of the reference points; and determining, for the target points, further coordinate values indicating an expected position of the target points on the examination object in the third spatial direction in each case, as determined further coordinate values, the determining of the further coordinate values being performed depending on the defined reference plane.
Florian Hoffmann, Falk Schlaudraff
Filed: 23 Jan 20
Utility
Method for calibrating a device for measuring the concentration of creatinine
16 Jan 24
A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
Thomas Kjaer, Thomas Pedersen Nyggard
Filed: 14 Dec 15
Utility
Oblique plane microscope for imaging a sample
16 Jan 24
An oblique plane microscope has an objective illuminating a plane of the sample and collecting detection light.
Benjamin Deissler
Filed: 5 Apr 21
Utility
Connector for aseptic connection, and method for connecting and disconnecting such connectors
9 Jan 24
A connector for forming a substantially aseptic connection is provided, said connector having a connector member a coupling end with a coupling element for engaging a similar coupling element on a similar connector to form a seal.
Klaus Gebauer
Filed: 29 May 19
Utility
Method and sensor for detecting presence or absence of a contaminant
2 Jan 24
The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200).
Peter Frischauf, Michael Taagaard, Flemming Aas
Filed: 1 Feb 22
Utility
Method and system for monitoring and controlling instruments
2 Jan 24
A method, system, gateway and computer program for remote controlling and monitoring of at least one instrument, for example a bioproces sing instrument.
Key Hyckenberg, Kjell Karlsson, Stefan Willehadson, Orjan Bo Grelsson
Filed: 28 Dec 22
Utility
Magnetic immunoglobulin-binding particles
19 Dec 23
The invention discloses an immunoglobulin-binding magnetic bead, comprising a porous matrix and one or more magnetic particles embedded in said matrix, wherein said matrix comprises a porous polymer and at least 10 mg/ml Fc-binding proteinaceous ligands covalently coupled to said porous polymer.
Ola Lind, Klaus Gebauer, Eric Faldt, Nils Norrman, Ronnie Palmgren, Jesper Hedberg, Niklas Jungnelius, Karl Liderfelt, Anita Solbrand
Filed: 21 Dec 17
Utility
Method and device for estimating a STED resolution
12 Dec 23
A method for estimating a stimulated emission depletion microscopy (STED) resolution includes generating a first frame representing a reference image from a field-of-view, the reference image having a predetermined reference resolution, and generating at least one second frame representing a STED image from the same field-of-view, the STED image having the STED resolution to be estimated.
Kai Walter, Lars Friedrich
Filed: 25 Mar 21
Utility
Optical imaging device for a microscope
12 Dec 23
An optical imaging device for a microscope comprises a first optical system configured to form a first optical image corresponding to a first region of a sample in accordance with a first imaging mode, a second optical system configured to form a second optical image corresponding to a second region of said sample, wherein said first and second regions spatially coincide in a target region of said sample and said first and second imaging modes are different from each other, a memory storing first distortion correction data suitable for correcting a first optical distortion caused by said first optical system in said first optical image, second distortion correction data suitable for correcting a second optical distortion caused by said second optical system in said second optical image, and transformation data suitable for correcting positional misalignment between said first and second optical images, and a processor which is configured to process first image data representing said first optical image based on said first distortion correction data for generating first distortion corrected image data, to process second image data representing said second optical image based on said second distortion correction data for generating second distortion corrected image data; and to combine said first and second distortion corrected image data based on said transformation data for generating combined image data representing a combined image which corresponds to said target region of said object.
Kai Ritschel, Marco Bingel, Patric Pelzer
Filed: 28 Oct 20
Utility
Tangential flow cassette-HF emulation
5 Dec 23
A biocompatible polymeric membrane includes pores defined between two material layers, where the first membrane material layer includes strips, and the second membrane material binds to each of the plurality of first membrane material layer strips includes a plurality of windows exposing each of the first membrane material strips.
Ralph Stankowski, Douglas Albagli, William A. Hennessy
Filed: 9 Oct 20
Utility
Methods and compositions for surface functionalization of optical semiconductor-integrated biochips
5 Dec 23
The present disclosure provides methods and compositions for surface functionalization of solid substrates.
Andrea Cuppoletti, Arjang Hassibi, Lei Pei, Yang Liu, Kshama Jirage, Arun Manickam
Filed: 7 Dec 21
Utility
Continuous perfusion bioreactor system
5 Dec 23
Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems.
Parrish M. Galliher, Geoffrey L. Hodge, Michael Fisher, Patrick Guertin, Dan Mardirosian
Filed: 5 Aug 21
Utility
Site-specific DNA modification using a donor DNA repair template having tandem repeat sequences
5 Dec 23
A method of site-specific modification of an endogenous target DNA of a eukaryotic cell is provided.
John Richard Nelson, Robert Scott Duthie, Patrick McCoy Spooner, John Anthony Schiel, Lisa Anne Lowery, Anja Josifa Smith
Filed: 19 Apr 17
Utility
System and method for tracking production line productivity with an industrial printer
5 Dec 23
A method and system for operating an industrial printer includes obtaining initial data that indicates the industrial printer used on a production line at a facility and a product to be output.
Robert V. Weaver, Robert K. Neagle, Randy Fischer
Filed: 8 Apr 19
Utility
Method for examining a sample, and device for carrying out such a method
5 Dec 23
In a method for the examination of a sample the sample is illuminated in a sample plane along a sample line with an illuminating light beam.
Werner Knebel, Florian Fahrbach
Filed: 6 Apr 21
Utility
Micropore membranes and methods of fabrication thereof using pillar templates
28 Nov 23
Porous liquid-filtering membranes having a repeatable distribution of pores of a small dimension are provided, as well as pillar templates that are used to produce such liquid filtering membranes.
Douglas Albagli, William A Hennessy
Filed: 31 Mar 21
Utility
Self-contained slide processing unit for biological specimens
28 Nov 23
A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit.
Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
Filed: 15 Jul 22
Utility
Preparation of a sample for high pressure freezing
28 Nov 23
A device for preparing a microscopic sample for a high-pressure freezing process in which the sample is provided using an arrangement having a middle plate of a high-pressure freezing cartridge and an incubation chamber, the middle plate being attached to and detachable from the incubation chamber by effecting a relative movement between the middle plate and the incubation chamber, and the sample being provided on an enclosing element which is fitted into an opening of the middle plate, wherein the device includes an engagement structure adapted to engage with the middle plate and to restrict a movement of the middle plate while the incubation chamber is moved, such as to effect the relative movement between the middle plate and the incubation chamber and to thereby detach the middle plate from the incubation chamber.
Rainer Wogritsch, Paul Wurzinger
Filed: 30 Aug 21
Utility
Method and system for deriving a digital representation of an unfolded blank and for cost estimation based upon the same
28 Nov 23
A computer-implemented method for creating a computer-aided design (CAD) corresponding to a 2-dimensional rendering of an unfolded blank configured for manipulation into a 3-dimensional shape.
Lieven Plettinck, Richard C. Deroo, Rian Goossens
Filed: 12 Nov 20
Utility
System and method for obtaining a uniform ink layer
21 Nov 23
A printing plate having a printing surface for receiving ink, including a defined area of an image intended to print with ink and a surface pattern applied to the defined area.
Peter Morisse, Wolfgang Sievers, Thomas Klein
Filed: 11 Jul 22