35 patents
Utility
Assays for detecting modified compounds
16 Jan 24
Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified.
Elazar Rabbani, Jannis G. Stavrianopoulos, Joshua Rabbani, Praveen Pande
Filed: 14 Oct 21
Utility
Sphingosine pathway modulating compounds for the treatment of cancers
9 Jan 24
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani, James J. Donegan
Filed: 19 Nov 20
Utility
Reduced background immunoassay plates
5 Sep 23
The invention provides reduced background substrates, such as multi-well plates, for use in enzyme-linked immunosorbent assays (ELISAs) and other ligand-binding assays, and methods for making and using the same.
Elazar Rabbani
Filed: 21 Jun 21
Utility
Sphingosine pathway modulating compounds for the treatment of coronavirus infection
15 Aug 23
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 10 Mar 21
Utility
Self-immolative probes for enzyme activity detection
30 May 23
Irina Lebedeva, Wayne Forrest Patton, Maciej Szczepanik, Yuejun Xiang, Praveen Pande
Filed: 28 May 20
Utility
Antibodies specific for sulfation sites of Wnt pathway proteins
2 May 23
Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a.
Joshua Rabbani, James J. Donegan
Filed: 22 Dec 20
Utility
Sphingosine pathway modulating compounds for the treatment of coronavirus infection
17 Jan 23
The invention provides methods and compositions for treating a coronavirus infection using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani
Filed: 10 Mar 21
Utility
Assays for detecting modified compounds
23 Nov 21
Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified.
Elazar Rabbani, Jannis G. Stavrianopoulos, Joshua Rabbani, Praveen Pande
Filed: 19 Dec 18
Utility
Immunomodulatory pharmaceutical compositions including a synthetic peptide and transforming growth factor beta
16 Nov 21
The invention provides immunomodulatory pharmaceutical compositions that include a synthetic peptide and transforming growth factor beta, (TGF-β).
Robert Nussenblatt, Baoying Liu, Lai Wei, Elazar Rabbani, James J. Donegan
Filed: 2 Jun 20
Utility
Methods for treating bone loss using sclerostin peptides
9 Nov 21
Provided is a composition comprising a peptide comprising amino acids and/or amino acid analogs comprising a continuous sequence of a sclerostin fragment comprising Tyr43 or Tyr213.
Joshua Rabbani, Xiaofeng Li, James J. Donegan
Filed: 29 Apr 19
Utility
Multisignal reagents for labeling analytes
2 Nov 21
Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer.
Jack Coleman, Maciej Szczepanik, Richard Jin
Filed: 9 Mar 20
Utility
Multisignal reagents for labeling analytes
27 Jul 21
Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer.
Jack Coleman, Maciej Szczepanik, Richard Jin
Filed: 28 Nov 18
Utility
Affinity tag nucleic acid and protein compositions, and processes for using same
20 Jul 21
The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides.
Elazar Rabbani, Jannis G. Stavrianopoulos, James J. Donegan, Wayne Patton, Juan Carcamo
Filed: 19 Dec 18
Utility
Multisignal labeling reagents and processes and uses therefor
8 Jun 21
Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group.
Jack Coleman, Elazar Rabbani, Jannis Stavrianopoulos, Praveen Pande
Filed: 26 Mar 20
Utility
Sphingosine kinase type 1 inhibitors and uses thereof
16 Mar 21
Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management.
Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
Filed: 10 Mar 20
Utility
Compounds and methods for detection of enzymes that remove methyl succinyl groups from epsilon-amino lysine moieties
16 Feb 21
Konrad T. Howitz, Zhongda Zhang, Anne Kisielewski, Elizabeth Dale, Wayne Forrest Patton
Filed: 30 Mar 20
Utility
Antibodies specific for sulfation sites of sclerostin
26 Jan 21
Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a.
Joshua Rabbani, James J. Donegan
Filed: 22 Sep 16
Utility
Sphingosine pathway modulating compounds for the treatment of cancers
4 Jan 21
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
Elazar Rabbani, James J. Donegan
Filed: 7 Apr 20
Utility
Fluorescent dyes and methods of use thereof
28 Dec 20
Zaiguo Li, Praveen Pande
Filed: 10 Sep 18
Utility
Monoazo dyes with cyclic amine as fluorescence quenchers
14 Dec 20
The present disclosure provides reactive quencher dyes that can be used in the detection and/or quantification of desirable target molecules, such as proteins, nucleic acids and various cellular organelles.
Zaiguo Li, Praveen Pande, Natarajan Raju
Filed: 5 Oct 18