1149 patents
Page 3 of 58
Utility
Contained Single-use Powder Induction System and Method of Use
7 Dec 23
A system and method is configured for inducing powder for pharmaceutical production.
Hongbo Mike Su, Hamza Ahsan, Jovilo Rotao Custodio, Jr., Dave Lam, Christian James Randecker, Keila L. Wedow
Filed: 22 May 23
Utility
Diagnostic and Therapeutic Methods for Cancer
7 Dec 23
Provided herein are diagnostic and therapeutic methods for the treatment of cancer using polygenic risk scores (PRSs) for endocrine diseases, including hypothyroidism.
G Scott CHANDLER, Zia KHAN
Filed: 10 Feb 23
Utility
Methods and Compositions for Cancer Immunotherapy
7 Dec 23
The present invention provides diagnostic methods, therapeutic methods, and compositions for the treatment of cancer.
Soren MULLER, Barzin Y. NABET, Namrata Srivastava PATIL, Romain Francois BANCHEREAU
Filed: 7 Dec 22
Utility
Automated Detection of Choroidal Neovascularization (CNV)
7 Dec 23
A method and system for detecting an advanced stage of age-related macular degeneration in a retina.
Xiaoyong WANG
Filed: 2 Jun 23
Utility
Polysorbate mixtures having modified fatty acid ester distribution
5 Dec 23
The present disclosure provides polysorbate 20 compositions with particular fatty acid ester concentrations.
Sandeep Yadav, Nidhi Doshi, Tamanna Shobha, Anthony Tomlinson, Amit Srivastava
Filed: 23 Sep 21
Utility
Bicyclic ketone compounds and methods of use thereof
5 Dec 23
Snahel Patel, Gregory Hamilton, Guiling Zhao, Huifen Chen, Blake Daniels, Craig Stivala
Filed: 12 Jan 21
Utility
Multiplexed target-binding candidate screening analysis
5 Dec 23
A method and system for normalizing a polymerase chain reaction (PCR) amplification process for a plurality of samples containing DNA.
Christian N. Cunningham, Kenneth Karl Hallenbeck
Filed: 14 Oct 21
Utility
Treatment of Breast Cancer Using Combination Therapies Comprising GDC-9545 and GDC-0077
30 Nov 23
Provided herein are combination therapies comprising GDC-9545 and GDC-0077 for treating locally advanced breast cancer or metastatic breast cancer.
Ciara METCALFE, Xiaojing WANG, Wei ZHOU
Filed: 15 Aug 23
Utility
Treatment of Breast Cancer Using Combination Therapies Comprising GDC-9545 and Abemaciclib or Ribociclib
30 Nov 23
Provided herein are combination therapies comprising GDC-9545 and abemaciclib or ribociclib for treating locally advanced breast cancer or metastatic breast cancer.
Ciara METCALFE, Pablo Diego PEREZ-MORENO, Xiaojing WANG
Filed: 15 Aug 23
Utility
Treatment of Breast Cancer Using Combination Therapies Comprising GDC-9545 and Ipatasertib
30 Nov 23
Provided herein are combination therapies comprising GDC-9545 and ipatasertib for treating locally advanced breast cancer or metastatic breast cancer.
Ciara METCALFE, Kui LIN, Marc Antoine HAFNER
Filed: 15 Aug 23
Utility
Estimation of Mechanistic Chromatography Model Uncertainty
30 Nov 23
A method, system, and non-transitory computer readable medium for estimating mechanistic chromatography model uncertainty.
Jessica Yang LYALL, Connor James THOMPSON, Sean Mackenzie BURGESS
Filed: 10 Aug 23
Utility
Prevention of Disulfide Bond Reduction During Recombinant Production of Polypeptides
30 Nov 23
The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides.
Yung-Hsiang KAO, Michael W. LAIRD, Melody Trexler SCHMIDT, Rita L. WONG, Daniel P. HEWITT
Filed: 31 Mar 23
Utility
ANTI-HtrA1 ANTIBODIES AND METHODS OF USE THEREOF
30 Nov 23
The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.
Robert F. KELLEY, Daniel K. Kirchhofer, Joyce Lai, Chingwei V. Lee, Wei-Ching Liang, Michael T. Lipari, Kelly M. Loyet, Tao Sai, Menno Van Lookeren Campagne, Yan Wu, Germaine Fuh
Filed: 21 Oct 22
Utility
TDO2 and IDO1 inhibitors
28 Nov 23
Presently provided are inhibitors of TD02 and IDO1 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.
Zhonghua Pei, Brendan Parr, Wendy Liu, Richard Pastor, Lewis Gazzard, Firoz Jaipuri, Sanjeev Kumar, Hima Potturi, Guoshen Wu, Xingyu Lin, Yanyan Chu, Powai Yuen
Filed: 28 Jun 18
Utility
CRISPR/Cas9 MULTIPLEX KNOCKOUT OF HOST CELL PROTEINS
23 Nov 23
The present disclosure relates to modified mammalian cells having reduced or eliminated expression of certain cellular proteins, CRISPR/Cas9 multiplex knockout strategies for making such cells, and methods of using such cells, e.g., in the context of cell-based therapy or as host cells in the production of a product of interest.
Amy SHEN, Inn Huam Yuk, Peggy Wai No Ko, Shahram Misaghi, Simon Thomas Auslaender, Midori Greenwood-Goodwin, Michael Wilson Laird, Benedikt Alois Claudius Oswald
Filed: 28 Feb 23
Utility
Prevention of Disulfide Bond Reduction During Recombinant Production of Polypeptides
16 Nov 23
The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides.
Yung-Hsiang KAO, Michael W. LAIRD, Melody Trexler SCHMIDT, Rita L. WONG, Daniel P. HEWITT
Filed: 1 May 23
Utility
Multiplexed Screening Analysis of Peptides for Target Binding
16 Nov 23
Methods, systems, and computer program products are provided for clustering of similar peptides to detect candidates for target binding.
Man-Ling Lee, Alberto Emilio Gobbi, Christian Nathaniel Cunningham
Filed: 21 Jun 23
Utility
Hydroxypropyl Methyl Cellulose Derivatives to Stabilize Polypeptides
16 Nov 23
The present invention provides formulations comprising polypeptides and hydroxypropyl methylcellulose acetate succinate (HPMCAS) derivatives.
Purnendu Kumar NAYAK, Debby Pei-Shan CHANG, Karthikan RAJAGOPAL, Jonathan ZARZAR
Filed: 31 Mar 23
Utility
Production of Heteromultimeric Proteins
9 Nov 23
Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target.
Justin SCHEER, Christoph SPIESS, Daniel G. YANSURA
Filed: 7 Apr 23
Utility
Results of Empacta: a Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Tocilizumab In Hospitalized Patients with COVID-19 Pneumonia
9 Nov 23
The application disclosed concerns a method of treating pneumonia in a patient who is not mechanically ventilated comprising administering an IL-6 antagonist (e.g. tocilizumab) to the patient in an amount effective to prevent the patient from dying or receiving mechanical ventilation.
Shalini V. MOHAN, William George REISS, Hoi Ying Linda YAU, Benjamin Howard KRAMER, Jian HAN
Filed: 19 Mar 21