3525 patents
Page 30 of 177
Utility
Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
7 Mar 23
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences.
Feng Zhang, Patrick Hsu, Chie-Yu Lin, Fei Ran
Filed: 9 Apr 20
Utility
Droplet-based method and apparatus for composite single-cell nucleic acid analysis
7 Mar 23
The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.
Aviv Regev, Evan Zane Macosko, Steven Andrew McCarroll, Alexander K. Shalek, Anindita Basu, Christopher B. Ford, Hongkun Park, David A. Weitz
Filed: 8 Mar 17
Utility
74ls37176neqzm9811w5uag5pis71ic6oozs2hqm3p1mxxp
7 Mar 23
Methods, apparatuses, and systems related to the electrochemical separation of target gases from gas mixtures are provided.
Sahag Voskian, Trevor Alan Hatton
Filed: 27 Aug 20
Utility
du5c94zvmic 2apz1brh1u8lpqi00h4my
7 Mar 23
The present disclosure relates to protein-polymer conjugates comprising an engineered binding oligomer protein and a polymer for detection of a ligand of interest, methods, compositions and kits thereof.
Bradley David Olsen, Hadley Sikes Johnson, Eric Alexander Miller, Justin Paloni
Filed: 26 Jul 19
Utility
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2 Mar 23
Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids.
Daniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
Filed: 7 Sep 22
Utility
qtok7fh35tpzlgww640d1hlblcuz
2 Mar 23
A method of generating an output trajectory of an ego vehicle is described.
Xiao LI, Brandon ARAKI, Sertac KARAMAN, Daniela RUS, Guy ROSMAN, Igor GILITSCHENSKI, Cristian-Ioan VASILE
Filed: 9 Jul 21
Utility
8fo1vndk0mdwo1qn1ti61ntznk4xyfnxcuig29ydvb62b3z6yndnu
2 Mar 23
Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9)-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 and a substitution of residues ADKKLRKRSGKLATE [SEQ ID No. 4] in position 365-379 in the ScCas9 open reading frame (Sc++).
Pranam Chatterjee, Noah Michael Jakimo, Joseph M. Jacobson
Filed: 30 Jun 22
Utility
lkn6oum1c91hwrvw uzti7zxx3lcis91hf
2 Mar 23
Disclosed are methods, compositions, reagents, systems, and kits to prepare and utilize branched multi-functional macromonomers, which contain a ring-opening metathesis polymerizable norbornene group, one or more reactive sites capable of undergoing click chemistry, and a terminal acyl group capable of undergoing a coupling reaction; branched multi-cargo macromonomers; and the corresponding polymers are disclosed herein.
Jeremiah A. Johnson, Nolan Gallagher, Farrukh Vohidov, Yivan Jiang, Hung Vanthanh Nguyen
Filed: 23 May 22
Utility
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28 Feb 23
A device for determining muscle condition of a region of tissue.
Seward B. Rutkove, Joel L. Dawson
Filed: 24 Apr 18
Utility
5kbscndt4si664ysn2jzbhiwhpuwbbbtr02d4qhn84i
28 Feb 23
Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (ATRA) prodrug covalently bound to the polymer by a hydrolysable linker L or a pharmaceutically acceptable salt thereof, and methods of using same to treat certain disorders.
Steven A. Castleberry, Mohiuddin A. Quadir, Paula T. Hammond
Filed: 23 Jun 16
Utility
p8z6yq3uoyaw51dzn z46v9gfdq1wvy4zhwiv60x1rimmbs8qrop7rz
28 Feb 23
Disclosed are methods, compositions, reagents, systems, and kits to prepare materials with viscoelastic properties that respond to irradiation with light.
Niels Holten-Andersen, Scott Charles Grindy
Filed: 17 May 18
Utility
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28 Feb 23
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences.
Feng Zhang, Beverly Davidson, Chie-Yu Lin, Edgardo Rodriguez
Filed: 30 Jan 19
Utility
5a0iz5x73wvl76933m q7m68wcrqceocn7jsn5e
28 Feb 23
The application relates to methods for compositions for identifying lncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype.
Julia Joung, Jesse Engreitz, Eric S. Lander, Feng Zhang
Filed: 4 May 18
Utility
ztsv6t6dqkbun608wx3clg5j4q1tk
28 Feb 23
Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
Timothy Kuan-Ta Lu, Mark K. Mimee, Christopher Voigt, Alex C. Tucker
Filed: 10 Jun 16
Utility
6vstdqo9yexn9cvt5pt656bkau0 x64v2mb40e7f7xsv
28 Feb 23
The disclosed invention is related to a universal strand-specific protocol for the sequencing preparation of all classes of RNA.
Alexander A. Shishkin, Mitchell Guttman, Christine F. Surka, Eric Lander
Filed: 30 Mar 20
Utility
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28 Feb 23
An evaporatively cooled device and a system including the same.
Kin Chung Fong, Dirk Robert Englund
Filed: 11 Aug 21
Utility
knm7bh1gsmj5xpf8elxvk8uhi29xe7bv9c07zym531q86n44rhkve4t6p61u
28 Feb 23
Described herein are a secure system for sharing private data and related systems and methods for incentivizing and validating private data sharing.
Zhizhuo Zhang, Manolis Kellis, Dianbo Liu, Anne Kim, Lauren Huang, Sandeep Nuckchady
Filed: 11 May 18
Utility
ytzbivs7maisrl 8k3t6egmydkmxnhg
28 Feb 23
Processes for optimizing the geometry of a blade for use in a propeller are disclosed.
Peter Sharpe, Keegan Quigley, Thomas Sebastian, Joseph Belarge, Ryan Fontaine, David Maurer
Filed: 25 Aug 20
Utility
x9ktddkmm7llh5xyzzlhbgen852p2ny8jry031glrh14owogp9o7uje4dxy
28 Feb 23
In one aspect, a method to determine a capacity of a microgrid includes applying a current test load to the microgrid and measuring a current through an energy storage device, the current indicating a charging status of the energy storage device based on a current load being applied to the microgrid through activated power outlets being served by the microgrid and the current test load, the energy storage device being integrated with the microgrid.
Brice MacLaren, James Macomber, Megan Richardson
Filed: 25 Feb 21
Utility
62uwf5tmjjpvvmknewuhf3jgjxys8r27i59dhjfbipzygb57ljslwg9l9m9s
28 Feb 23
The present invention generally relates to a modular microjet cooler.
James Paul Smith, Bernard A. Malouin, Jr., Eric A. Browne
Filed: 26 Apr 21