1604 patents
Utility
Synthetic 5' UTR sequences, and high-throughput engineering and screening thereof
16 Jan 24
Disclosed herein are novel 5′ UTR sequences that can be used to control gene expression in various contexts.
Timothy Kuan-Ta Lu, Manolis Kellis, Jicong Cao, Eva Maria Novoa Pardo, Zhizhuo Zhang
Filed: 14 Jun 19
Utility
System and method for an optical blood flow measurement
16 Jan 24
An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.
Maria Angela Franceschini, Stefan Carp, Davide Tamborini, David Boas, Bruce Rosen, Megan Blackwell, Oleg Shatrovoy
Filed: 18 Feb 19
Utility
SARS-CoV-2 antigens and uses thereof
16 Jan 24
The present disclosure relates to, inter alia, variants of the receptor binding domain of a coronavirus (e.g., SARS-CoV-2) having increased immunogenicity and reduced aggregation, and the use of the RBD variants in methods for preventing infection of the coronavirus.
J. Christopher Love, Sergio Andre Rodriguez Aponte, Neil Chandra Dalvie
Filed: 28 Oct 21
Utility
Porous medium with adjustable fluid permeability and associated systems and methods
16 Jan 24
The present disclosure is related to porous media with adjustable fluid permeabilities and related systems and methods.
Yayuan Liu, Trevor Alan Hatton
Filed: 30 Mar 21
Utility
Additive manufacturing of composite powders
16 Jan 24
Compositions and methods of making compositions for additive manufacturing of composite powders including metal ceramic alloyed material is described.
Ethan Parsons
Filed: 5 Nov 21
Utility
Swellable and structurally homogenous hydrogels and methods of use thereof
16 Jan 24
The invention encompasses hydrogels, monomer precursors of the hydrogels, methods for the preparation thereof, and methods of use therefor.
Ruixuan Gao, Linyi Gao, Chih-Chieh Yu, Edward Stuart Boyden
Filed: 5 Feb 19
Utility
Nanostructures for the assembly of materials
16 Jan 24
Nanostructures and associated compositions, systems, and methods are provided.
Robert J. Macfarlane, Jianyuan Zhang, Peter Jeffries Santos, Paul Anthony Gabrys
Filed: 5 Aug 21
Utility
Electrically conductive firebrick system
16 Jan 24
A thermal energy storage system includes a firebrick checkerwork and an electrode.
Charles Forsberg, Daniel C. Stack
Filed: 31 Aug 21
Utility
Compositions and methods for treating bacterial infections
9 Jan 24
Provided herein are compositions and methods for therapeutic and/or prophylactic treatment of an intracellular bacterial infection in a subject in need thereof, comprising one or more modulating agents, wherein the one or more modulating agents increase expression of IFNγ, IL-2, TNF, and/or IL-17 in systemic and/or lung T cells.
Alexander K. Shalek, Travis Hughes, Marc H. Wadsworth, Robert Seder, Mario Roederer, Joanne L. Flynn, Patricia Darrah
Filed: 30 Dec 20
Utility
Scalable and safe nanocrystal precursor
9 Jan 24
A semiconductor nanocrystal can be made by an in situ redox reaction between an M donor and an E donor.
Moungi Bawendi, Daniel Franke, Matthias Ginterseder
Filed: 12 Jan 21
Utility
Biomass conversion reactors and associated systems and methods
9 Jan 24
Systems and methods associated with biomass decomposition are generally described.
Kevin S. Kung, Alexander H. Slocum, Santosh Janardhan Shanbhogue, Ahmed Fouad Ghoniem, Robert James Stoner
Filed: 28 Apr 22
Utility
Systems, methods, and compositions for targeted nucleic acid editing
9 Jan 24
The invention provides for systems, methods, and compositions for targeting and editing nucleic acids.
Feng Zhang, David Benjamin Turitz Cox, Jonathan Gootenberg, Omar O. Abudayyeh, Bernd Zetsche, Jonathan Strecker
Filed: 18 May 18
Utility
Programmable nanolithography mask
9 Jan 24
Conventional optical lithography uses masks with static patterns that are expensive and labor intensive to produce.
Aik Jun Tan, Mantao Huang, Geoffrey S. D. Beach
Filed: 2 Apr 21
Utility
Universal guessing random additive noise decoding (GRAND) decoder
9 Jan 24
Described is a decoder suitable for use with any communication or storage system.
Amit Solomon, Muriel Medard, Kenneth R. Duffy, Rabia Tugce Yazicigil Kirby, Vaibhav Bansal, Wei An
Filed: 8 Apr 21
Utility
Electrochemical capture of Lewis acid gases
2 Jan 24
Methods, apparatuses, and systems related to electrochemical capture of Lewis acid gases from fluid mixtures are generally described.
Sahag Voskian, Trevor Alan Hatton, Cameron G. Halliday
Filed: 22 Oct 21
Utility
Multi-specific antibodies with affinity for human A33 antigen and DOTA metal complex and uses thereof
2 Jan 24
Described herein are multi-specific binding agents that bind A33 and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid.
Sarah Cheal, Hong Xu, Steven Larson, Nai-Kong Cheung, Karl Dane Wittrup, Alice Tzeng
Filed: 13 Apr 21
Utility
All-optical spatial light modulator
2 Jan 24
A spatial light modulator (SLM) comprised of a 2D array of optically-controlled semiconductor nanocavities can have a fast modulation rate, small pixel pitch, low pixel tuning energy, and millions of pixels.
Christopher Louis Panuski, Dirk Robert Englund
Filed: 29 Mar 21
Utility
Chemical and physical sensing with a reader and RFID tags
2 Jan 24
A method of detecting a stimulus can include detecting an output from a radio frequency identification tag including a sensor.
Timothy Manning Swager, Joseph Michael Azzarelli, Jens Bomholdt Ravnsbæk, Katherine Andrea Mirica
Filed: 17 Dec 18
Utility
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
19 Dec 23
Described in exemplary embodiments herein are methods, compositions, and kits for diagnosing, prognosing, monitoring, treating and/or preventing a hemopoietic malignancy and/or relapse thereof in a subject.
Alexander K. Shalek, Peter Winter, David Weinstock, Mark Murakami, Scott Manalis, Andrew Navia, Jennyfer Galvez-Reyes
Filed: 30 Oct 20
Utility
3-d printed devices formed with magnetic inks and methods of making graded index structures
19 Dec 23
A 3-D printed device comprising one or more structures, the structures comprising a plurality of magnetically responsive particles and one or more diblock or triblock copolymers; the diblock or triblock copolymers having an A-B, A-B-A, or A-B-C block-type structure in which the A-blocks and C-blocks are an aromatic-based polymer or an acrylate-based polymer and the B-blocks are an aliphatic-based polymer.
Theodore H. Fedynyshyn, Jennifer A. Lewis, Bradley P. Duncan
Filed: 1 May 20