1604 patents
Page 2 of 81
Utility
Structure-guided chemical modification of guide RNA and its applications
19 Dec 23
The disclosure relates to compositions comprising and methods for chemical modification of single guide RNA (sgRNA), tracrRNA and/or crRNA used individually or in combination with one another or Cas system components.
Hao Yin, Daniel G. Anderson, Robert S. Langer
Filed: 3 Feb 17
Utility
Circular RNA for translation in eukaryotic cells
19 Dec 23
Methods and constructs for engineering circular RNA are disclosed.
Daniel G. Anderson, Robert Alexander Wesselhoeft, Piotr S. Kowalski
Filed: 23 Aug 22
Utility
Measuring representational motions in a medical context
19 Dec 23
A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.
Randall Davis, Dana L. Penney
Filed: 2 Feb 21
Utility
Compositions and methods for promoting hemostasis and other physiological activities
12 Dec 23
Compositions that include nanoscale structured materials or precursors thereof (e.g., self: assembling peptides) are described.
Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David K. C. Tay, Shuguang Zhang
Filed: 5 Apr 16
Utility
Switchable system for high-salinity brine desalination and fractional precipitation
12 Dec 23
A saline feed stream flows into a liquid-liquid extraction system; and a volatile organic solvent flows through a main compressor.
Aaron D. Wilson, John Lienhard, Akshay Deshmukh, Zi Hao Foo
Filed: 3 Jan 22
Utility
Type VI CRISPR orthologs and systems
12 Dec 23
The invention provides for systems, methods, and compositions for targeting nucleic acids.
Feng Zhang, David Benjamin Turitz Cox
Filed: 11 Apr 18
Utility
Heterogeneous subsurface imaging systems and methods
12 Dec 23
A system for near-surface subsurface imaging for detecting and characterizing subsurface heterogeneities comprises a non-contact acoustic source that senses a plurality of acoustic waves that travel through a surface; an instrument that outputs probing electromagnetic signals through the surface that interact and are affected by scattered signals of the acoustic waves and further senses vibrational modes of a subsurface below the surface; an imaging device that dynamically generates a time sequence of images of properties of the acoustic waves and maps elastic wave fields of the acoustic waves; and a processor that analyzes dynamic multi-wave data of the images to quantify spatial variations in the mechanical and viscoelastic properties of the subsurface.
Stephen Brown, Thomas Szabo, Daniel R. Burns, Michael Fehler
Filed: 10 Oct 19
Utility
Proteomics and spatial patterning using antenna networks
12 Dec 23
The application relates to methods and systems for proteomics and spatial mapping of biomolecules using a next generation sequencing readout to decipher biomolecular and cellular interaction networks.
Aviv Regev, Jellert Gaublomme
Filed: 13 Mar 19
Utility
Active piezoelectric sheet with piezoelectric microstructures
12 Dec 23
An active acoustic system includes a thin-film sheet having an array of piezoelectric microstructures embossed in the film.
Jinchi Han, Jeffrey H. Lang, Vladimir Bulovic
Filed: 22 Oct 21
Utility
Modular glaucoma implant
5 Dec 23
A modular glaucoma implant for the treatment of glaucoma is described.
Matthew L. Cavuto, Dalia P. Leibowitz, Callum Joseph Macintosh
Filed: 15 Jun 18
Utility
Nanoparticles with pH triggered drug release
5 Dec 23
Provided is a nanoparticle comprising a pH-responsive polymer, a pH-insensitive polymer and a payload molecule.
Sunandini Chopra, Rohit Karnik, Amy Wang, Omid C. Farokhzad, Xue-Qing Zhang
Filed: 7 Oct 16
Utility
Multi-dimensional double spiral device and methods of use thereof
5 Dec 23
Described is a multi-dimensional double spiral (MDDS) microfluidic device comprising a first spiral microchannel and a second microchannel, wherein the wherein the first spiral microchannel and second spiral microchannel have different cross-sectional areas.
Jongyoon Han, Hyungkook Jeon
Filed: 29 Sep 21
Utility
Aerial vehicle with tape spring arms
5 Dec 23
An aerial vehicle with a plurality of selectively collapsible arms capable of transitioning between an extended state and a contracted state is described.
David Patterson, Mark Silver
Filed: 9 Mar 21
Utility
Supercapacitors and other electrodes and methods for making and using same
5 Dec 23
Systems and methods involving nanomaterial-based electrodes, such as supercapacitor and battery electrodes that can be flexible, are described.
Karen K. Gleason, Brian L. Wardle, Estelle Cohen, Yue Zhou, Xiaoxue Wang, Yosef Stein
Filed: 14 May 20
Utility
Current rectification based on noncentrosymmetric quantum materials
5 Dec 23
Rectification is a process that converts electromagnetic fields into direct current (DC).
Hiroki Isobe, Qiong Ma, Liang Fu, Nuh Gedik, Suyang Xu, Pablo Jarillo-Herrero
Filed: 11 Jun 21
Utility
Noise recycling
5 Dec 23
Described are concepts, systems, devices and methods that enhance decoding performance of channels subject to correlated noise.
Muriel Medard, Kenneth R. Duffy, Amit Solomon, Alejandro Cohen
Filed: 22 Jul 22
Utility
Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
5 Dec 23
This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE).
Omar Abudayyeh, Jonathan Gootenberg
Filed: 14 Dec 22
Utility
Trans-activated functional RNA by strand displacement and uses thereof
5 Dec 23
The present disclosure, at least in part, relates to an engineered RNA (e.g., microRNA and sgRNA), in the absence of an input signal, that is engineered to have a large enough energy gap between the formations of a first secondary structure, which is unrecognizable by an actuator, and a second secondary structure, which is recognizable by an actuator (e.g., Drosha and Cas protein).
Ron Weiss, Giulio Alighieri
Filed: 25 Sep 20
Utility
Sensors for detecting and imaging of cancer metastasis
5 Dec 23
In some aspects, the disclosure relates to compositions and method for detection, classification, and treatment of cancer.
Sangeeta N. Bhatia, Liangliang Hao
Filed: 17 Jan 20
Utility
Scanning optical imaging device
5 Dec 23
The present disclosure pertains to an apparatus and methods of an imaging device for obtaining images from the walls of luminal organs or a surgical cavity.
Kaicheng Liang, James G. Fujimoto, Osman Oguz Ahsen, Michael Gene Giacomelli, Hsiang-Chieh Lee, Zhao Wang
Filed: 3 May 18